Development of T Cell Immunity

Adrian Liston is Professor in Autoimmune Genetics at the University of Leuven and the VIB, Belgium. His PhD research was on T cell tolerance and diabetes with Professor Chris Goodnow at the Australian National University, followed by post-doctoral research on regulatory T cell biology with Professor Sasha Rudensky at the University of Washington. The Liston laboratory is supported by an ERC Start Grant, a JDRF Career Development Award, a VIB Investigators Award and grants from the FWO and KUL. Adrian Liston has published more than 70 papers, with over 3000 citations, including key publications on the function of Aire in thymic tolerance, defective tolerance in the NOD mouse, the contribution of immunodeficiency to autoimmunity, microRNA function in regulatory T cells, the discovery of the follicular regulatory T cell, the role of microRNA in the thymic epithelium and the homeostatic control over regulatory T cells.

Development of T cell immunity



The development of T cell immunity – Adrian Liston
The evolution of T cell immunity

Genome duplication and T cell immunity – Masanori Kasahara



Questions arising from "Genome duplication and T cell immunity" – Claude Perreault
Response to questions – Masanori Kasahara



The origin and role of MHC class I-associated self peptides – Claude Perreault



Questions arising from "The origin and role of MHC class I-associated self peptides" – Masanori Kasahara
Response to questions – Claude Perreault

Thymic requirements for T cell immunity



Transcriptional regulation of thymus organogensis and thymic epithelial cell differentiation – Nancy Manley and Brian Condie
Early T cell differentiation: lessons from T-cell acute lymphoblastic leukemia – Cedric S Tremblay, Thu Hoang and Trang Hoang
T cell immunity in the periphery

Lymphoid tissue inducer cells and the evolution of CD4 dependent high affinity antibody responses – Peter J L Lane, Fiona M McConnell, David Withers, Fabrina Gaspal, Manoj Saini and Graham Anderson



Commentary on "Lymphoid tissue inducer cells and the evolution of CD4 dependent high affinity antibody responses" – Mark Coles, Dimitri Kioussis and Henrique Veiga-Fernandes



Cellular and Molecular Requirements in Lymph Node and Peyer’s Patch Development – Mark Coles, Dimitri Kioussis and Henrique Veiga-Fernandes
T follicular helper cells during Immunity and Tolerance – Michelle A. Linterman and Carola G. Vinuesa
Preventing T cell-dependent autoimmunity

Thymic selection and lineage commitment of CD4+Foxp3+ regulatory T cells – Paola Romagnoli and Joost P.M. van Meerwijk
Molecular Mechanisms of Regulatory T cell Development and Suppressive Function – Jeong M. Kim





Is Foxp3 the master regulator of regulatory T cells? – Adrian Liston