Cell Cycle and Growth Control – Biomolecular Regulation and Cancer 2e

Dr. Gary S. Stein is Haidak Distinguished Professor and Chairman, Department of Cell Biology, and Professor of Medicine, University of Massachusetts Medical School, and Professor of Medicine. He is also Deputy Director for Research at the University of Massachusetts Cancer Center. The central theme of Dr. Stein's research has been to discover mechanisms controlling proliferation and differentiation with emphasis on compromised regulation that is linked with disease. Dr. Stein has also had major and lasting impact in skeletal biology, where he established the foundation for addressing bone tissue specific gene expression, and provided valuable insight into aberrations that accompany the onset and progression of skeletal disease. Dr. Arthur B. Pardee is Professor Emeritus, Harvard University. For over 20 years he was Professor of Biological Chemistry and Molecular Pharmacology, Harvard University, and Chief, Division of Cell Growth and Regulation, Dana--Farber Cancer Institute. He is an elected fellow of the American Association for the Advancement of Science, and has served as president of the American Society of Biological Chemists and American Association for Cancer Research. Dr. Pardee's pioneering work in mammalian cells is the foundation for our current understanding of mechanisms that govern competency for proliferation and cell cycle progression.

Preface. Contributors. PART I. 1. Cell Fates (Arthur B. Pardee). 2. Architectural Organization of the Regulatory Machinery for Transcription, Replication, and Repair: Dynamic Temporal--Spatial Parameters of Cell Cycle Control (Corey D. Braastad, Sayyed K. Zaidi, Martin Montecino, Jane B. Lian, Andre J. van Wijnen, Janet L. Stein, and Gary S. Stein). PART II. 3. Cell Cycle Regulatory Cascades (Heide L. Ford, Robert A. Sclafani, and James Degregori). 4. Membrane Receptors and Signal Transduction Pathways in G1: Regulation of Liver Regeneration and T Cell Proliferation (Joseph F. Porter and David T. Denhardt). 5. Onset of DNA Synthesis and S Phase (G. Prem--Veer Reddy, Eugenia Cifuentes, Uma Bai, Mani Menon, and Evelyn R. Barrack). 6. The Progression and Regulation of Mitotic Events (Greenfield Sluder, Edward H. Hinchcliffe, and Conly L. Rieder). 7. Cell Cycle Inhibitory Proteins (Carmen Carneiro and Andrew Koff). 8. Chromatin Remodeling and Cancer (Cynthia J. Guidi and Anthony N. Imbalzano). 9. Extracellular Matrix:Tissue--Specific Regulator of Cell Proliferation (Aylin Rizki and Mina J. Bissell). 10. Angiogenesis and Blood Supply (Judah Folkman). 11. Regulation of Cell Growth, Differentiation, and Death during Metamorphosis (Hans Laufer and Eric H. Baehrecke). 12. Translational Control and the Cell Cycle (Robert E. Rhoads). PART III. 13. Telomere Structure and Function Provides Insights into the Generation of Genomic Instability and Carcinogenesis (Colleen Fordyce and Thea D.Tlsty). 14. Immortalization by SV4O Large T Antigen (Rowena L. Lock, Silvia Benvenuti, and Parmjit S. Jat). 15. Apoptosis Signaling in Normal and Cancer Cells (Shulin Wang and Wafik S. El--Deiry). PART IV. 16. Mutagenesis, Mutations, and DNA Repair (Roger D. Johnson). 17. Oncogenes (Stacey J. Baker and E. Premkumar Reddy). 18. Role of the Retinoblastoma Family in Cell Cycle Progression and Growth Control (Valeria Masciullo and Antonio Giordano). 19. p53 Tumor--Suppressor Genes (Faith A. Zamamiri--Davis and Gerard P. Zambetti). PART V. 20. Cell Cycle and Growth Control: Current Clinical Applications (Michael Deininger). PART VI. 21. Misregulated Fate Cancer (Arthur B. Pardee). Index.