Biometals & Ligands for Anticancer Drug Design

E A Parfenov and G E Zaikov

Contents: Introduction; The Search for Antitumour Agents Among Complex Copper Compounds; SOD Models as Anticarcinogens; Resemblance and Differences of SOD Models and Enzymes. Probable Functions of SOD Models in Biological Systems; Cytotoxic Activity of SOD Models; Mechanisms of Physiological Compatibility of SOD Models 1 -- The Role of Ligand Selection for the SOD Model Design; Mechanisms of Physiological Compatibility of SOD Models 2 -- Effects in the Cell Redox Potential; Mechanisms of Physiological Compatibility of SOD Models 3 -- Interaction with the Immune System; Mechanisms of Physiological Compatibility of SOD Models 4 -- Gene Expression; Mechanisms of Physiological Compatibility of SOD Models 5 -- Overcoming of the Drug Resistance; If a Universal Antioxidant is Possible.