Concise Guide to Hematology

Dr Alvin H. Schmaier is the Robert W. Kellermeyer Professor of Hematology and Oncology and Chief of Hematology and Oncology at Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio. He is formally a Professor at Temple University and the University of Michigan. At both institutions he was Director of the Coagulation Laboratory and at the University of Michigan he was course Director of the Hematology sequence from 1999-2005. His research area is in the field of hemostasis, thrombosis, and vascular biology. He was an Associate Editor of Thrombosis and Haemostasis and serves as an Advisor to the Journal of Thrombosis and Haemostasis. He is the President of Thromgen, Inc, an early-stage cardiovascular pharmacology company. He is the author of 114 peer-reviewed papers, 70 review articles, 13 editorials, 1 book and 8 patents. Dr Hillard Lazarus is a tenured full Professor of Medicine in the Division of Hematology-Oncology and the Director of the Stem Cell Transplant Program at the Ireland Cancer Center, University Hospitals Case Medical Center. Dr Lazarus was the Chair of the Stem Cell Transplant Committee of the Eastern Cooperative Oncology Group (ECOG) from the time it was established in the mid-1980s. Dr Lazarus has been identified as an Outstanding Physician in national and local surveys. He has over 250 publications in peer-reviewed journals, 43 book chapters and 50 review articles. He is Co-Editor of the journal Bone Marrow Transplantation and also is an editor of three textbooks in the field of blood and bone marrow transplantation, hematologic malignancies, and supportive care for cancer patients.

List of Contributors ix Preface xii 1 Introduction to Hematology 1 Alvin H. Schmaier 2 Hematopoiesis 6 Yuan Lin and Stanton L. Gerson 3 Red Blood Cell Biochemistry and Physiology 16 Kevin T. McDonagh 4 Anemia: Clinical Approach 24 Peter W. Marks 5 Iron Deficiency 35 Alice Ma 6 Vitamin-B12 (Cobalamin) and Folate Deficienc, 44 As'ok C. Antony 7 Congenital Hemolytic Anemia, 62 Archana M. Agarwal and Josef T. Prchal 8 Acquired Hemolytic Anemia, 75 Scott D. Gitlin 9 Overview of Hemostasi, 91 Alvin H. Schmaier 10 Approach to the Bleeding Patien, 103 Alvin H. Schmaier 11 Congenital Bleeding Disorder, 112 Anjali A. Sharathkumar and Steven W. Pipe 12 Acquired Bleeding Disorder, 131 Howard A. Liebman 13 Platelet Function in Hemostasis and Inherited Disorders of Platelet Number and Function 140 A. Koneti Rao and David W. Essex 14 Acquired Thrombocytopenia 154 Theodore E. Warkentin and Andrew E. Warkentin 15 Thrombosis and Anticoagulation 174 Alvin H. Schmaier 16 Myeloid Cell Physiology and Disorders 184 Alvin H. Schmaier, Lilli M. Petruzzelli, Niels Borregaard and Laurence A. Boxer 17 Bone Marrow Structure and Diagnostic Testing 197 Howard J. Meyerson and Hillard M. Lazarus 18 Myeloproliferative Neoplasms and Myelodysplastic Syndromes 220 Gabriela Motyckova and Richard M. Stone 19 Acute Leukemia 235 Tsila Zuckerman and Jacob M. Rowe 20 Classifi cation of Lymphoma 251 Yi-Hua Chen and Amy Chadburn 21 Clinical Evaluation and Management of Lymphoma 268 Makiko Ban-Hoefen, Jonathan W. Friedberg and Richard I. Fisher 22 Plasma Cell Disorders 287 Sumit Madan and Philip R. Greipp 23 Pediatric Hematology 307 Sanjay P. Ahuja 24 Blood Banking 319 Lawrence Tim Goodnough 25 Transfusion Therapy 332 Beth H. Shaz and Christopher D. Hillyer 26 Hematopoietic Cell Transplantation 344 Hillard M. Lazarus 27 Atlas of Hematology Slides 363 Alvin H. Schmaier Index 389