Basic, Clinical and Therapeutic Aspects of Alzheimer's and Parkinson's Diseases

Plenary Lectures.- Functional Principles Implied in Neurological Symptoms.- The Neurobiology of Alzheimer's Disease.- Role of Brain Monoamines and Other Neurotransmitters in Normal and Pathological Aging.- Amyloid.- Molecular Genetics of Alzheimer's Disease.- Proteins and Proteolysis in the Pathogenesis of Alzheimer's Disease.- Amyloid ? Protein Precursors Having Proteinase Inhibitor Regions Are Highly Expressed in Alzheimer's Disease Brains.- Differential Expression of Three Types of Amyloid Protein Precursor mRNA in Alzheimer's Disease Brain.- Protease Inhibitor and Cholinergic System in Alzheimer's Disease.- Structure and Expression of mRNA for the Mouse Homolog of Alzheimer Amyloid Beta Protein Precursor.- Molecular Cloning and Structural Analysis of the Human Amyloid ? Protein Precursor Gene.- Protease Nexin 1 Immunoreactivity in Senile Plaques in Alzheimer Disease and Aged Brain.- Monoclonal Antibodies Against Senile Plaque Amyloid in Alzheimer's Disease.- Identification of Putative Amyloid A4-Splitting Enzymes with Two Endopeptidases Widely Distributed in Mammalian Cells.- Proteolytic Processing of ?-Protein Precursor-Related Synthetic Peptides.- Degeneration of Neuronal Processes in Rats Induced by the Protease Inhibitor Leupeptin.- ?1-Antichymotrypsin Influences the Survival of Neurons.- Evidence for a Neuronal Origin of Senile Plaques in Down's Syndrome Brains.- Serum Amyloid P Immunoreactivity in Cortical Tangles, Plaques and Vessels in Alzheimer's Disease: Implications for Dysfunction of the Blood-Brain Barrier ?.- Monoamine Oxidase B Activity in Senile Plaque.- Light and Electron Microscopic Observations of Diffuse Plaque and Its Related Conditions.- ?-Amyloid Plaques and Dementia: An Immunohistochemical Study.- Diagnosis of Cerebral Amyloid Angiopathy with Cerebral Hemorrhage by Enzyme-Linked Immunosorbent Assay (ELISA) of Cystatin C in Cerebrospinal Fluid.- Cystatin C (?-Trace) and ?-Protein Coexist in the Cerebral Amyloid Angiopathy Causing Cerebral Hemorrhage and Consequential Vascular Dementia.- The Neuronal Breakdown-1 (Alzheimer).- The Regulation of Cytoskeletal Elements in Differentiating Human Neuroblastoma and Rat Pheochromocytoma PC-12 Cells.- Some Findings on Intermediate Filaments in Alzheimer's Disease.- A Unifying Hypothesis on the Etiology of Alzheimer's Disease.- Abnormal Phospholipid Metabolism in Neurodegenerative Diseases: Elevations in Glycerophosphocholine and Glycerophosphoethanolamine Levels in Brain of Alzheimer's Disease but Not in Down Syndrome Patients.- Alterations in Catecholamine and Peptide Neurons in the Locus Coeruleus in Dementias of Alzheimer's and Parkinson's Disease.- The Role of Neuronal Membranes Deterioration in the Pathogenesis of Alzheimer's Disease: An Ultrastructural Perspective.- Experimental Synaptic Degeneration as a Model for the Pathogenesis of Alzheimer's Disease: Monoclonal Antibodies and a Protein Kinase Inhibitor Block Synapse Formation and Maintenance between Cultured CNS Neurons.- Pathobiochemical Aspects of Parkinson's Disease and Dementia of Alzheimer Type.- Characterization of Alzheimer Neurofibrillary Tangle (NFT) Epitopes and the Binding Site for the Regulatory Subunit (RII) of cAMP-Dependent Protein Kinase II in Human Microtubule-Associated Protein 2 (MAP-2).- Identification and Characterization of Modified Forms of Tau in Brains with Alzheimer's Disease.- Phosphorylation of Tau Protein with a Novel Tau Protein Kinase Forming Paired Helical Filament Epitopes on Tau.- Aberration of Vimentin Array in Fibroblast from Familial Alzheimer's Disease.- Regional Phospholipid Profile of Alzheimer's Brain: 31P and Proton NMR Spectroscopic Studies of Membrane Lipid Extracts.- Age-Related Changes in the Rate and Composition of the Slow Axonal Transport.- Astroglial Gene Expression in the Hippocampus following Partial Deafferentation in the Rat and in Alzheimer's Disease.- Blood-Brain Barrier Disturbance in Patients with Alzheimer's Disease Is Related to Vascular Factors.- An Early Change of Neurofibrillary Tangle Formation.- Monoclonal Antibodies against Paired Helical Filament in Alzheimer's Disease and Parkinsonism-Dementia Complex of Guam.- Neuronal Breakdown-2 (Parkinson).- Patterns of Vulnerability of Mesostriatal Neurons.- Complex I Deficiency in Parkinson's Disease and MPTP-Induced Experimental Parkinsonism.- Biochemical Reactions Leading to Parkinsonian Symptoms Elicited by MPTP.- Enzymological Aspects of the Actions of the Parkinsonism-Inducing Neurotoxin MPTP.- Biochemical Studies on Predisposition to Parkinson's Disease.- Parkinsonism Produced by an Endogenous Substance, Tetrahydroisoquinoline, in Monkeys and Mice.- Tetrahydroisoquinoline Alkaloids in Neurodegenerative Disorders - Influence of Drug Treatment.- Chronic L-Dopa Therapy in Parkinson's Disease: Can It Accelerate Degeneration of Nigrostriatal Dopaminergic Neurons ?.- Iron-Melanin Interaction in Substantia Nigra as the Neurotoxic Component of Parkinson's Disease.- Dopamine Immunocytochemistry in the Nigrostriatal System of Pre- and Postnatal Mice.- The Effects of N-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Administration to Maternal Mice on the Catecholamine System in the Brain of Postnatal Mice.- Mitochondrial Abnormalities in the Nigral Neurons of Crab-Eating Monkeys with Experimental Parkinsonism.- L-Dopa-Induced Facilitation of Dopamine Release Via Presynaptic ?-Adrenoceptors in Striatal Slices from MPTP-Treated C57BL Mice: Evaluation of the Action of L-Dopa in Animal Model for Parkinsonism.- Functional Alterations in Striatal Cholinergic and Striato-Nigral GABA-Ergic Neurons following 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Administration.- Hemiparkinsonism in Monkeys after Unilateral Striatum Infusion of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP).- Cyclosporin A Enhances Neurotoxicity of N-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) in Mice.- Effects of Various Drugs on Behavior and Striatal Dopamine Contents in MPTP-Treated Mice Exposed to Stress.- Acute Effects of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) on Body Temperature of Various Strains of Mice.- Effect of MPP+ and TIQ on Cultured Rat Midbrain Dopaminergic Neurons.- Assay System for Neurotoxicants Causing Parkinson's Disease: 1-Methyl-4-Phenylpyridinium Ion (MPP+) Inhibits Survival of Cultured Neurons from Substantia Nigra of Fetal Monkey (Macaca fascicularis).- The Effect of Tetrahydroisoquinoline on the Mitochondrial Respiration.- Detection of Tetrahydroisoquinoline, a Parkinsonism-Related Compound, in Parkinsonian Brains and Foods by Gas Chromatography-Mass Spectrometry.- Biosynthesis of N-Methylisoquinolinium Ion, a Potent Inhibitor of Catecholamine Metabolism, from 1,2,3,4-Tetrahydroisoquinoline through N-Methyl-1,2,3,4-Tetrahydroisoquinoline in Human Brain.- Importance of 1-Methyltetrahydroisoquinoline (1MeTIQ) in Parkinson's Disease.- Formation of a Novel and Neurotoxic Tetrahydroisoquinoline Derivative, 1,3-Dimethyltetrahydroisoquinoline (1,3DiMeTIQ), a Condensation Product of Amphetamines and Acetaldehyde in Vivo.- Tryptophan Metabolites in Parkinson's Brain.- A Parallel Relationship between Parkinson's Disease and an Excess of S-Adenosylmethionine-Dependent Biological Methylation in the Brain.- Dopa and Dopamine Cause the Destruction of Cultured Nerve Cells in the Presence of Iron: Possible Mechanism of the Nigral Degeneration in Parkinson's Disease.- Food-Derived Heterocyclic Amines as Potent Inhibitors of Catecholamine Metabolism.- Pathology and Histology.- Senile Changes in the Human Olfactory Bulbs.- Large Neurons in the Neostriatum and Basal Nucleus of Meynert: Simultaneous Decrease in Alzheimer's Disease.- A Comparison of "s Brain: 31P and Proton NMR Spectroscopic Studies of Membrane Lipid Extracts.- Age-Related Changes in the Rate and Composition of the Slow Axonal Transport.- Astroglial Gene Expression in the Hippocampus following Partial Deafferentation in the Rat and in Alzheimer's Disease.- Blood-Brain Barrier Disturbance in Patients with Alzheimer's Disease Is Related to Vascular Factors.- An Early Change of Neurofibrillary Tangle Formation.- Monoclonal Antibodies against Paired Helical Filament in Alzheimer's Disease and Parkinsonism-Dementia Complex of Guam.- Neuronal Breakdown-2 (Parkinson).- Patterns of Vulnerability of Mesostriatal Neurons.- Complex I Deficiency in Parkinson's Disease and MPTP-Induced Experimental Parkinsonism.- Biochemical Reactions Leading to Parkinsonian Symptoms Elicited by MPTP.- Enzymological Aspects of the Actions of the Parkinsonism-Inducing Neurotoxin MPTP.- Biochemical Studies on Predisposition to Parkinson's Disease.- Parkinsonism Produced by an Endogenous Substance, Tetrahydroisoquinoline, in Monkeys and Mice.- Tetrahydroisoquinoline Alkaloids in Neurodegenerative Disorders - Influence of Drug Treatment.- Chronic L-Dopa Therapy in Parkinson's Disease: Can It Accelerate Degeneration of Nigrostriatal Dopaminergic Neurons ?.- Iron-Melanin Interaction in Substantia Nigra as the Neurotoxic Component of Parkinson's Disease.- Dopamine Immunocytochemistry in the Nigrostriatal System of Pre- and Postnatal Mice.- The Effects of N-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Administration to Maternal Mice on the Catecholamine System in the Brain of Postnatal Mice.- Mitochondrial Abnormalities in the Nigral Neurons of Crab-Eating Monkeys with Experimental Parkinsonism.- L-Dopa-Induced Facilitation of Dopamine Release Via Presynaptic ?-Adrenoceptors in Striatal Slices from MPTP-Treated C57BL Mice: Evaluation of the Action of L-Dopa in Animal Model for Parkinsonism.- Functional Alterations in Striatal Cholinergic and Striato-Nigral GABA-Ergic Neurons following 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Administration.- Hemiparkinsonism in Monkeys after Unilateral Striatum Infusion of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP).- Cyclosporin A Enhances Neurotoxicity of N-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) in Mice.- Effects of Various Drugs on Behavior and Striatal Dopamine Contents in MPTP-Treated Mice Exposed to Stress.- Acute Effects of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) on Body Temperature of Various Strains of Mice.- Effect of MPP+ and TIQ on Cultured Rat Midbrain Dopaminergic Neurons.- Assay System for Neurotoxicants Causing Parkinson's Disease: 1-Methyl-4-Phenylpyridinium Ion (MPP+) Inhibits Survival of Cultured Neurons from Substantia Nigra of Fetal Monkey (Macaca fascicularis).- The Effect of Tetrahydroisoquinoline on the Mitochondrial Respiration.- Detection of Tetrahydroisoquinoline, a Parkinsonism-Related Compound, in Parkinsonian Brains and Foods by Gas Chromatography-Mass Spectrometry.- Biosynthesis of N-Methylisoquinolinium Ion, a Potent Inhibitor of Catecholamine Metabolism, from 1,2,3,4-Tetrahydroisoquinoline through N-Methyl-1,2,3,4-Tetrahydroisoquinoline in Human Brain.- Importance of 1-Methyltetrahydroisoquinoline (1MeTIQ) in Parkinson's Disease.- Formation of a Novel and Neurotoxic Tetrahydroisoquinoline Derivative, 1,3-Dimethyltetrahydroisoquinoline (1,3DiMeTIQ), a Condensation Product of Amphetamines and Acetaldehyde in Vivo.- Tryptophan Metabolites in Parkinson's Brain.- A Parallel Relationship between Parkinson's Disease and an Excess of S-Adenosylmethionine-Dependent Biological Methylation in the Brain.- Dopa and Dopamine Cause the Destruction of Cultured Nerve Cells in the Presence of Iron: Possible Mechanism of the Nigral Degeneration in Parkinson's Disease.- Food-Derived Heterocyclic Amines as Potent Inhibitors of Catecholamine Metabolism.- Pathology and Histology.- Senile Changes in the Human Olfactory Bulbs.- Large Neurons in the Neostriatum and Basal Nucleus of Meynert: Simultaneous Decrease in Alzheimer's Disease.- A Comparison of "Pure" Alzheimer's Disease and Alzheimer's Disease Plus Vascular Lesions (Mixed Dementia) in the Elderly.- Choline Acetyltransferase and Substance P Level in Alzheimer's Disease and Multi-Infarct Dementia.- A Study on Postmortem Changes in Vasopressin mRNA in Rat Brain Using a Non-Isotopic Method.- Topographical Distribution, Fine Structure of Component Fibrils, and Immunoreactivity of Neuronal Inclusions in Alzheimer's, Parkinson's, and Pick's Diseases.- Neuronal Loss in the Substantia Nigra and Ventral Tegmental Area in Parkinson's Disease and Alzheimer's Disease.- Characteristics of Reactive Microglia in Alzheimer's and Parkinson's Disease Brain Tissue.- Alzheimer - Parkinson Disease Spectrum and Diffuse Lewy Body Disease.- Acetylcholinesterase Histochemical Changes in the Cerebral Cortex of Alzheimer's Disease.- Basement Membrane Components in Alzheimer's Disease.- Regulation of Cerebral Cortical and Hippocampal Blood Flow by Cholinergic Fibers Originating in the Nucleus Basalis of Meynert and Septal Complex.- Immune System Reaction to Model Lesions of Rat Brain.- Computer-Aided Quantitative Analysis of the Distribution of Catecholamine-Containing Fibers in the Primate Prefrontal Cortex.- Nigrostriatal Loop Disruption in Parkinson's Disease and Striatonigral Degeneration.- Immunocytochemical Studies of Substance P and Met-Enkephalin in the Globus Pallidus of Progressive Supranuclear Palsy.- Heterogeneous Distribution of L-Dopa Immunoreactivity in Dopaminergic Neurons of the Rat Midbrain.- Transmitter.- Cholinergic Systems in Alzheimer's Disease, Parkinson's Disease and Progressive Supranuclear Palsy.- Neurochemical Aspects of Parkinson's Disease and the Dementing Brain Disorders: Relation to Brain Ageing.- Neuropharmacology and Functional Anatomy of the Basal Ganglia: Experimental Models for Parkinson's and Alzheimer's Disease.- Neurotransmitter Changes in Alzheimer-Type Dementia and Therapeutic Strategies.- In Vitro Experimental Approach for Determination of the Central Cholinergie Neuronal Activity.- Pharmacological Profile of Brain Glucose Utilization Obtained by Monitoring of Lactate Release in Vivo under the Free Moving Condition.- Behavioral and Neurochemical Evaluation of Stroke-Prone Spontaneously Hypertensive Rats for Vascular Dementia-Animal Model.- Acetylcholinesterase of Cerebral Microvessels Changes in Alzheimer's Disease.- Genes of Human Catecholamine-Synthesizing Enzymes.- Gene Activity and Neurodegeneration in the Extrapyramidal System: A Progress Report on Molecular and Morphological Correlates.- Analysis of Dopamine and Neuropeptides in 6-OHDA-Lesioned Rats.- Enhancement of in Vivo Dopamine Release from the Rat Striatum by 6R-L-Erythro-5,6,7,8-Tetrahydrobiopterin as Studied by Brain Dialysis.- Preparation of Antigen and Antibody to 3-Methoxy-4-Hydroxyphenyl Glycol (MHPG).- Study of Central Putative Neurotransmitters in Rodent Models of Parkinsonism.- Possible Factors Responsible for Adverse Effects of Long-Term L-Dopa Therapy: Simultaneous Determinations of Dopamine Parameters in Rats.- Generating and Controlling Multiparameter Data Bases for Biochemical Correlates of Disorders.- NEUBA (R) A Multicolumn, Multidetector Liquid Chromatograph with Electrochemical Detection for Use in the Identification and Determination of Neurochemicals and Related Species.- Examination of Central Nervous System Effects of Amphetamine Using NEUBA (R).- Application of Multi-Dimensional Liquid Chromatography (NEUBA (R) to the Determination of Neuronal Changes in an Organism.- Patterns of Tyrosine and Tryptophan Metabolites in Controls and Various Degenerative Disorders.- Receptor.- Dementia in Parkinson's Disease and Central Cholinergic Function.- Subtypes of Nicotinic Receptors in Human Cortex: Selective Changes in Alzheimer Disease.- Alterations in Muscarinic Cholinergic Receptors and the Second Messenger System in the Cerebral Cortex in Alzheimer-Type Dementia.- Expression of Nicotinic Acetylcholine Receptor mRNA in the Rat Cerebral Cortex after Lesioning of the Nucleus Basalis Magnocellularis.- Studies of Central Nervous System Cholinergic Receptors in Alzheimer's Disease (AD).- Cerebellar Excitatory Amino Acid Binding Sites Are Differentially Altered in Alzheimer's Disease.- Pre- and Postsynaptic Cortical Glutamatergic Binding Sites in Alzheimer's Disease.- Reduced N-Methyl-D-Aspartate (NMDA) Receptor-Ion Channel Complex in Alzheimer's Disease Frontal Cortex.- The Influence of Priming on the Behavioral Expression of Dopamine Receptor Supersensitivity in Basal Ganglia.- M1 Receptors Stimulate Dopamine Release Via Protein Kinase C in the Striatum of Freely Moving Rat Studied by Brain Dialysis.- Effect of MPTP on Dopamine D2 Receptors in the Aging Mouse Striatum.- Age-Dependent Effects of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) in the Rat.- More Rapid Development of Supersensitivity of D-2 Receptors than D-1 Receptors as Examined by Rotational Behavior.- Features of the Dopaminergic Neurotoxicity of Methamphetamine: A Comparison with MPTP.- Alteration of [3H]Ins(1,4,5)P3 and [3H]PDBu Binding Sites in Brains of Patients with Parkinson's Disease and Multiple System Atrophy.- NGF and Physiology.- The Mechanism of Action of Nerve Growth Factor.- Nerve Growth Factor Promotes Survival of Cultured Cholinergic Neurons from Nucleus Basalis of Meynert of 2-Week-Old Rats.- Alterations in Nerve Growth Factor Receptor Containing Neurons in Parkinson's Disease.- A Striatal-Derived DA Neuron Growth Factor: Implication in Parkinson's Disease.- Co-Localization of Cholinergic and GABAergic Traits in in Vitro Septohippocampal Neurons from Developing Rats.- A Hippocampal Cell Line Expresses a Membrane-Associated Cholinergic Trophic Activity Not Attributable to Nerve Growth Factor.- Interleukin-6 as a Neurotrophic Factor for Promoting Survival of Septal Cholinergic Neurons and Mesencephalic Catecholaminergic Neurons from Postnatal Rats.- Distribution of NGF Receptors in Control and Alzheimer's Disease Basal Forebrain.- Trophic Effects of Hippocampus Cell Membrane Fragments on Cultured Medial Septal Cholinergic Neurons.- Changes in Basal Forebrain Cholinergic Systems Following Excitotoxic Cell Death in the Hippocampus and Cerebral Neocortex.- Interleukin-3 Promotes Neurite Outgrowth and Elevates Choline Acetyltransferase Activity.- Memory Impairment in Rats Induced by an Active Fragment of Nerve Growth Factor Antibody.- Brain's Calculating Principle.- Screening for Psychotherapeutic Chemicals by Analysis of Conscious Activity in the Mouse.- Regulation of Neocortical Electrical Activity by Cholinergic and Noradrenergic Systems.- Ascending Cholinergic and Monoaminergic Systems in the Brainstem: Do They Constitute a Reticular Activating System ?.- Role of the Medial Limbic System in the Memory Process: A Hypothesis Based on a Radioactive 2-Deoxyglucose Study.- Effect of Magnetism on Learning Function.- Model.- Morphological Changes of the Brain in Senescence Accelerated Mouse (SAM)-P/8, a Newly Developed Memory-Deficient Strain.- Age-Related Changes in Blood-Brain Barrier (BBB).- Effect of Aging on NADPH-Diaphorase Neurons in Laterodorsal Tegmental Nucleus and Striatum of Senescence Accelerated Mouse (SAM).- Senescence-Accelerated Mouse SAM-P/8 Shows Spontaneous Age-Related Impairment of Ability of Acquisition of Learning and Memory: An Animal Model of Disturbances in Recent Memory with Aging.- An Experimental Animal Model for the Study of Cholinergic and Serotonergic Neuronal Activity in Aging Brain.- Aging Effects on Schedule-Control Discrimination Learning Test in Aged Rats as a Model of Alzheimer's Disease.- Effect of the Basal Forebrain Lesions on Memory and Learning Performance in Mice.- Effects of Destruction of Nucleus Basalis Meynert on Operant Study and Neurotransmitters in Rats.- Characteristic of Learning Deficit Induced by Ibotenic Acid Lesion of the Frontal Cortex Related with the Nucleus Basalis of Meynert in Rats.- A New Animal Model of Alzheimer's Disease by Selective Destruction of the Cholinergic Neurons in the Basal Forebrain.- Impairment of Avoidance Behavior Produced by Destruction of the Cholinergic Projection from the Pedunculopontine Nucleus to the Medial Thalamus.- Impaired Spatial Learning in Rats With a Trimethyltin-Induced Hippocampal Lesion and the Effect of Fetal Septal Grafting on the Impairment.- Some Effects of CNS Cholinergic Neurons on Memory and ACh Release.- Carbon Monoxide (CO)-Induced Delayed Amnesia and Delayed Neuronal Death.- Graft.- Modifications in the Levels of Antibodies in the CSF of Parkinson's Disease Patients following Adrenal-to-Brain Transplantation.- Autotransplantation of Parasympathetic Cholinergic Neurons into Alzheimer Model Rat Brain.- Use of MPTP-Hemiparkinsonian (HP) Monkeys to Evaluate Efficacy of Tissue Implants as a Treatment for Parkinson's Disease.- Autotransplantation of Sympathetic Ganglion into the Brain of Parkinsonian Monkey.- Long-Term Survival of Grafted Cells, Dopamine Synthesis/Release, Receptor Activity, and Functional Recovery after Grafting of Fetal Nigral Cells in Model Animals of Hemi-Parkinson's Disease.- Intra-Accumbens Dopaminergic Grafts Restore Methamphetamine-Induced Locomotor Hyperactivity Response and the Release and Metabolism of Dopamine in Rats Having 6-OHDA Lesions in the Ventral Tegmental Area.- Investigation of MHC Antigens on Neural Graft in Mouse Parkinson's Models.