Alzheimer's Disease

Preface Contributors Part I Scientific Background of Alzheimer's Disease 1 Genetics of Alzheimer's Disease and Related Disorders John Hardy 2 Neuropathology of Alzheimer's Disease Christian Schultz, Kelly Del Tredici, and Heiko Braak 3 Oxidative Stress in the Development of Alzheimer's Disease and Other Dementias Domenico Pratico 4 Metabolism and Alzheimer's Disease John P. Blass Part II Epidemiology 5 Alzheimer's Disease: Epidemiological and Statistical Data Brigitte Zoeller Richter and Ralph W. Richter 6 The Economic Burden of Alzheimer's Disease and Dementia Anders Wimo and Bengt Winblad 7 Potential and Established Risk Factors for Alzheimer's Disease Brigitte Zoeller Richter Part III Clinical Assessment 8 Medical Diagnosis and Workup of Alzheimer's Disease Ralph W. Richter 9 Neuroimaging Techniques: CT, MRI, SPECT, PET Norman L. Foster 10 Computer-assisted cognitive assessment & enhancement (K. Wesnes, MD, UK) 11 Normal Pressure Hydrocephalus (P. Reyes, Prof., San Antonio, TX & R.W. Richter, Prof. Tulsa, OK) 12 Interface between depression and cognitive impairment (D.P. Devanand, Prof., Columbia U, NY) 13 Insulin, Diabetes, Alzheimer Disease - the interplay (S. Kraft, Prof. U Seattle/WA) AD and the eye (retinal amyloid plaques) 14 Inflammatory and immunological aspects of dementia (D. Morgan, Prof., U South Florida) 15 Non pharmacological interventions in dementia (A. Burns, Prof. U Manchester/UK) 16 Biological Markers in Alzheimer's Disease Ramon Diaz-Arrastia and Fred Baskin 17 The Neuropsychology of Alzheimer's Disease Kirsten I. Taylor and Andreas U. Monsch 18 Vascular Cognitive Impairment in Clinical Practice Kenneth Rockwood and Timo Erkinjuntti 19 Lewy Body Disease Robert Barber, Jane Newby, and Ian G. McKeith 20 Frontotemporal Lobe Dementia Malgorzata Franczak, Diana Kerwin, and Piero Antuono Part IV The Transitional Stage 21 Mild Forgetfulness: Distinguishing Early AD from Normal Aging Scott A. Small 16 Mild Cognitive Impairment: What the Physician Should Know Brigitte Zoeller Richter vii 22 Diagnosis of Predementia AD in a Clinical Setting Pieter Jelle Visser 23Loss of Olfactory Function in Patients With Alzheimer's Disease Claire Murphy and Paul E. Gilbert Part V Treatment Options 24 Treatment of Alzheimer's Disease: Basic Considerations Brigitte Zoeller Richter and Ralph W. Richter 25 Donepezil in Treatment of AD Ging-Yuek Robin Hsiung and Howard Feldman 26 Rivastigmine for Treatment of AD Martin R. Farlow 27 Galantamine in Treatment of AD M. Saleem Ismail and Pierre N. Tariot 28 Memantine in Treatment of AD Hans Jorg Mobius 29 Alternative Treatment Options Brigitte Zoeller Richter Part VI Late-Stage Therapy 30 Pain and Palliative Care in Late-Stage Dementia Patients Sophie Pautex, Dina Zekry, Gilbert Zulian, Gabriel Gold, and Jean-Pierre Michel 31 Cardiological Issues in Late-Stage Alzheimer's Disease: A Clinician's Approach Jose R. Medina Part VII Prevention Strategies 32 Neuroprotection and Neurodegenerative Disease Frank John Emery Vajda 33 Neurotrophic Factors for Prevention of Alzheimer's Disease Mark H. Tuszynski 34 Statins in Prevention and Treatment of Alzheimer's Disease David A. Drachman 35 Potential Role of Androgens and Androgen Receptors in Alzheimer's Disease Jacob Raber 36 Role of Nutrition in Prevention or Delay of Alzheimer's Disease Hannes B. Staehelin 37 Impact of Physical Activity on Prevention of Alzheimer's Disease Danielle Laurin, Rene Verreault, and Joan Lindsay Part VIII Future Developments 38 Stem Cell Therapy for Alzheimer's Disease Kiminobu Sugaya 39 Secretases as