Aspergillus fumigatus and Aspergillosis

Table of Contents


Introduction, David A. Stevens


I. The Species



Morphology and Reproductive Mode of Aspergillus fumigatus, Robert A. Samson, Janos Varga, and Paul S. Dyer
Molecular Methods for Species Identification and Strain Typing of Aspergillus fumigatus, S. Arunmozhi Balajee and Corne H. W. Klaassen
Aspergillus fumigatus Specificities as Deduced from Comparative Genomics, Amandine Gastebois, Karine Lambou, Joanne Wong Sak Hoi, and Fredj Tekaia
Essential Genes in Aspergillus fumigatus, Wenqi Hu, Bo Jiang, and Terry Roemer


II. Growth and Sensing, or Resisting Environmental Stress

Aspects of Primary Carbon and Nitrogen Metabolism, Sven Krappmann
Phospholipases of Aspergillus fumigatus, Geoffrey D. Robson
Aspergillus fumigatus Secreted Proteases, Michel Monod, Olivier Jousson, and Utz Reichard
Cations (Zn, Fe), Jose Antonio Calera and Hubertus Haas
Conidial Germination in Aspergillus fumigatus, Nir Osherov
Growth Polarity, Michelle Momany and Yainitza Hernandez-Rodriguez
Biofilm Formation in Aspergillus fumigatus, Anne Beauvais and Frank-Michael Muller
Signal Transduction, Gregory S. May and Taylor Schoberle
Cell Wall of Aspergillus fumigatus: a Dynamic Structure, Isabelle Mouyna and Thierry Fontaine
Genetic Regulation of Aspergillus Secondary Metabolites and Their Role in Fungal Pathogenesis, Robert A. Cramer, Jr., E. Keats Schwab, and Nancy P. Keller
Aspergillus fumigatus: Survival and Death Under Stress, David S. Askew and Judith C. Rhodes


III. Immune Defense Against Aspergillus

Reactive Oxygen Intermediates, pH and Calcium, Elaine Bignell
Innate Defense against Aspergillus: the Phagocyte, Michel Chignard
Interactions of Aspergillus Infection and Allergy, Luigina Romani
Dendritic Cells in Aspergillus Infection and Allergy, Luigina Romani
CD4+ T-Cell Responses to Aspergillus fumitagus, Amariliz Rivera and Eric G. Pamer
Innate Recognition of Aspergillus fumigatus by the Mammalian Immune System, Lisa M. Graham and Gordon D. Brown


IV. The Spectrum of the Disease

Invasive Pulmonary Aspergillosis, Aimee K. Zaas and Barbara D. Alexander
Aspergillus Sinusitis and Cerebral Aspergillosis, Stefan Schwartz and Markus Ruhnke
Chronic Aspergillosis, David W. Denning
Allergic Bronchopulmonary Aspergillosis, Richard B. Moss


V. Diagnosis

27. Histology and Radiology, Reginald Greene, Kazutoshi Shibuya, and Tsunihiro Ando

28. Galactomannan and Anti-Aspergillus Antibody Detection for the Diagnosis of Invasive Aspergillosis, Paul E. Verweij

29. Aspergillus PCR, P. Lewis White and Rosemary A. Barnes



VI. Therapy

30. Antifungal Polyenes, Andreas H. Groll and Thomas J. Walsh

31. Azoles, Raoul Herbrecht and Yasmine Nivoix

32. Echinocandins in the Treatment of Aspergillosis, Johan Maertens and Vincent Maertens

33. Antifungal Drug Interactions, Russell E. Lewis

34. Antifungal Mechanisms of Action and Resistance, David S. Perlin and Emilia Mellado

35. Immunotherapy, Brahm H. Segal and Luigina R. Romani



VII. Timing of Antifungal Therapy

36. Prophylaxis against Invasive Aspergillosis, Jo-Anne H. Young

37. Therapy of Invasive Aspergillosis: Current Consensus and Controversies, Dimitrios P. Kontoyiannis and Kieren A. Marr



VIII. Specific Patient Populations

38. Invasive Aspergillosis in Solid Organ Transplant Recipients, Hsin-Yun Sun, Patricia Munoz, Emilio Bouza, and Nina Singh

39. Invasive Aspergillosis in Malignancy and Stem Cell Transplant Recipients, Elio Castagnola and Claudio Viscoli

40. Invasive Aspergillosis in Pediatric Patients, Emmanuel Roilides and Paraskevi Panagopoulou



Conclusion

41. A Perspective View on Aspergillus fumigatus Research for the Next Ten Years, Jean-Paul Latge and William J. Steinbach