Textbook of Nephro-Endocrinology

Dr. Singh has led groundbreaking studies in anemia of kidney disease, including the CHOIR study, which was published in the New England Journal of Medicine, and well as being a member of the steering committees for the TREAT and DRIVE studies. More recently, he has taken on the role of leading the ASCEND Clinical development program - a phase 3 program for the development of a novel propyl hydroxylase inhibitor Daprodustat. The trial is aiming to recruit 7500 patients in over countries. He currently leads the office of Postgraduate Medical Education at the Brigham and Women's Hospital, and in this capacity leads several HMS CME courses. He is the author of over 160 original contributions and review articles, as well as author/editor of 11 books in internal medicine and nephrology. Dr. Singh is a Fellow of the Royal College of Physicians in London, and has an MBA from Boston University. Dr. Gordon H. Williams is an endocrinologist in Boston, Massachusetts and is affiliated with Brigham and Women's Hospital. He received his medical degree from Harvard Medical School and has been in practice for more than 30 years. He has published ~300 papers, is a well-respected and well-known expert, speaker and leader in the field of endocrinology.

Part 1: The Kidney as an Endocrine Organ Section 1: Erythropoietin 1. Erythropoientin: An Historical Overview of Physiology, Molecular Biology And Gene Regulation 2.Erythropoiesis: The Role of Erythropoietin and Iron 3.Extra-Hematopoietic Action of Erythropoietin 4.Development of Recombinant Erythropoietin and Erythropoietin Analogues 5.Erythropoietin Disease States & Resistance Section 2: Vitamin D, PTH and Novel Regulators of Phosphate 6. Vitamin D and the Kidney: Introduction and Historical Perspective 7.Vitamin D: Molecular Biology and Gene Regulation 8.Molecular Biology of Parathyroid Hormone 9.Endocrine Regulation of Phosphate Homeostasis Section 3: Renin-angiotensin 10.Introduction and Historical Overview 11.Molecular Biology of Renin and Regulation of Its Gene 12. Physiology and Regulation of the RAAS System 13. The Renin Angiotensin Aldosterone System and the Kidney 14. The Renin Angiotensin and the Heart 15. The Renin-Angrotensin blockade: Therapeutic Agents

Part 2: The Kidney as a Hormonal target Section 4: Anti-diuretic Hormone 16. Vasopressin in the Kidney: Historical Aspects 17. Molecular Biology and Gene Regulation 18. Vasopressin Antagonists in Physiology and Disease 19. Diabetes Insipidus and SIADH Section 5: The Atrial Natriuretic Peptides 20. ANP, BNP and CNP Physiology and Pharmacology of the Cardiorenal Axis Section 6: Aldosterone 21.Introduction and Historical Overview 22.Aldosterone Receptors and Their Renal Effects: Molecular Biology and Gene Regulation 23. Aldosterone and Its Cardiovascular Effects 24. Aldosterone Regulation Section 7: Endocrine Disorders in Renal Failure 25. Insulin resistance 26. Growth hormone 27. Sexual Dysfunction in Men and Women with Chronic Kidney Disease 28. Thyroid Status in Chronic Renal Failure Patients 29.Metabolic Acidosis of Chronic Kidney Disease 30.Pregnancy and the Kidney