Sjogren's Syndrome

Sjogren's syndrome is an autoimmune disorder in which immune cells attack and destroy the exocrine glands that produce tears and saliva. This work examines the clinically important aspects of this disorder and features articles on topics including: pathogenesis; hepatitis C involvement; measurement of disease activity; and, management of dry eye.

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Sjogren's syndrome, an autoimmune disorder in which immune cells attack and destroy the exocrine glands that produce tears and saliva, afflicts somewhere between 1 and 4 million people in the United States. This issue of "Rheumatic Disease Clinics of North America" examines the clinically important aspects of this disorder and features articles on the following topics: pathogenesis; hepatitis C involvement; measurement of disease activity; relationship to other autoimmune disorders; involvement of the respiratory tract; involvement of the nervous system; lymphoma and Sjogren's syndrome; fatigue; optimizing dry mouth treatment; management of dry eye; issues in DMARD and biological therapy; and, therapeutic potential for B-cell modulation.