Liver Cirrhosis: From Pathophysiology to Disease Management

Pathomechanisms of fibrogenesis: initiation.- Apoptosis and oncotic necrosis: profibrotic signalling mechanisms of cell death.- The mucosal immune system in the pathogenesis of liver disease.- Immune responses in hepatitis C virus infection.- Inflammatory pathways in liver homeostasis and liver injury.- Pathomechanisms of fibrogenesis: mediators.- A complex network of intra- and intercellular mediators regulate cellular activation and transdifferentiation of hepatic stellate cells.- Genetic determinants of liver fibrogenesis: a systems genetics approach in recombinant inbred mice.- Molecular mechanisms of fibrosis progression in non-alcoholic steatohepatitis (NASH).- New role of bile acid metabolism in intestinal bacteria translocation.- Cellular responses to chronic liver injury.- The hepatic stellate cell: a progenitor cell.- Role of non-parenchymal cells in portal hypertension.- Role of angiogenesis in portal hypertension.- Current concept of hepatic fibrogenesis in mouse models of liver fibrosis.- Hepatic fibrogenesis and carcinogenesis: Krüppel-like factors and beyond.- Clinical management of progressive liver fibrosis.- Biomarkers of liver fibrosis.- Clinical evaluation of disease progression in chronic liver disease: towards an integrated system?.- Fibrosis regression and innovative antifibrotic therapies: from bench to bedside.- Clinical management of portal hypertension: preprimary and primary prophylaxis.- Dynamic increase of intrahepatic vascular resistance in cirrhosis.- Remodelling portal hypertension: preprimary prophylaxis.- When and how to scope in portal hypertension.- Prevention of first variceal bleeding.- Clinical management of portal hypertension: complications of cirrhosis.- Therapy of acute variceal bleeding.- Prevention of variceal rebleeding.-From sodium retention to refractory ascites: the role of new drugs.- Transjugular intrahepatic portosystemic shunt versus paracentesis: a critical review of randomized studies and meta-analyses.- Spontaneous bacterial peritonitis — A disease of the gut? Therapeutic implications.- Hepatorenal syndrome — A defined entity with a standard treatment?.- From infections to hepatic encephalopathy.- Liver and lung — Treatment of hepatopulmonary diseases.- Allocation in adult liver transplantation: is the Model for Endstage Liver Disease the solution?.- Emerging future therapies for portal hypertension.