Applications of Antisense Therapies to Restenosis -

Applications of Antisense Therapies to Restenosis

LeRoy E. Rabbani (Herausgeber)

Buch | Hardcover
184 Seiten
1999
Springer (Verlag)
978-0-7923-8423-6 (ISBN)
160,49 inkl. MwSt
Restenosis, the proliferation of smooth muscle cells that line blood vessels, often follows angioplasty. This work addresses the potential of using antisense therapies to inhibit the restenosis that occurs after percutaneous transluminal angioplasty and coronary stenting.
Restenosis, the proliferation of smooth muscle cells (SMC) that line blood vessels, often follows angioplasty. Despite advances in cardiology, restenosis continues to affect up to 40% of the over 500,000 patients who undergo angioplasty each year. Applications of Antisense Therapies to Restenosis is the first volume to address the potential of using antisense therapies to inhibit the restenosis that occurs after percutaneous transluminal angioplasty and coronary stenting. The work critically examines the application of various antisense therapies for inhibiting restenosis.

1 Restenosis: The Clinical Problem.- 2 The Pathobiology of Restenosis. A Paradigm from Clinical and Experimental Studies.- 3 Coronary Repair and Restenosis Cellular Basis for Antisense Approaches.- 4 Vascular Smooth Muscle Cell Biology and Restenosis.- 5 Vascular Antisense Therapy Directed Against c-myc, c-myb, and PCNA.- 6 Phosphorothioate Oligodeoxynucleotides as Inhibitors of gene Expression: Antisenseand Non-Antisense Effects.- 7 Molecular Therapies for Vascular Disease: Altering the Balance Between Cell growth and Cell Death.- 8 Oligonucleotides Containing the G-Quartet Sequence Motif.- 9 Non-G-Quartet, Non-Sequence Specific Antirestenotic Effects of Phosphorothioate Oligodeoxynucleotides.- 10 Local Delivery of Antirestenotic Drugs.- 11 Critical Considerations and Future Directions.

Erscheint lt. Verlag 28.2.1999
Reihe/Serie Perspectives in Antisense Science ; 3
Zusatzinfo VIII, 184 p.
Verlagsort Dordrecht
Sprache englisch
Maße 155 x 235 mm
Themenwelt Medizinische Fachgebiete Chirurgie Herz- / Thorax- / Gefäßchirurgie
Medizinische Fachgebiete Innere Medizin Kardiologie / Angiologie
Studium 2. Studienabschnitt (Klinik) Humangenetik
ISBN-10 0-7923-8423-7 / 0792384237
ISBN-13 978-0-7923-8423-6 / 9780792384236
Zustand Neuware
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