Novartis Foundation 293 – Genetic Effects on Environmental Vulnerability to Disease

Prof Sir Michael Rutter, King's College, London, UK Prof Rutter is the leading child psychiatrist in the UK. He set up the MRC Child Psychiatry Research Unit and the Institute of Psychiatry's Social, Genetic and Developmental Psychiatry Centre. He was Deputy Chairman of the Wellcome Trust from 1999 to 2004, and has been a Trustee of the Nuffield Foundation since 1992. He was elected a Fellow of the Royal Society in 1987 and an honorary member of the British Academy in 2002.?He was a Founding Fellow of the Academia Europaea and the Academy of Medical Sciences, of which he is currently Clinical Vice-President. He has published extensively.

1. Michael Rutter Introduction: whither gene-environment interactions? 2. Rudolf Uher Gene-environment interaction: overcoming methodological challenges Discussion 3. Marco Battaglia, Cecilia Marino, Michel Maziade, Massimo Molteni and Francesca D'Amato Gene-environment interaction and behavioural disorders: a developmental perspective based on endophenotypes Discussion 4. Naomi R. Wray, William L. Coventry, Michael R. James, Grant W. Montgomery, Lindon J. Eaves and Nicholas G. Martin Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events: an application of Item Response Theory Discussion Appendix General discussion I 5. Harold Snieder, Xiaoling Wang, Vasiliki Lagou, Brenda W. J. H. Penninx, Harriette Riese and Catharina A. Hartman Role of gene-stress interactions in gene-finding studies Discussion 6. Kenneth A. Dodge Practice and public policy in the era of gene-environment interactions Discussion 7. Kristi B. Adamo and Frederique Tesson Gene-environment interaction and the metabolic syndrome Discussion General discussion II 8. Stephen P. Robertson and Richie Poulton Longitudinal studies of gene-environment interaction in common diseases-good value for money? Discussion 9. Kee-Seng Chia Gene-environment interactions in breast cancer Discussion 10. Malak Kotb, Nourtan Abdeltawab, Ramy Aziz, Sarah Rowe, Robert W. Williams and Lu Lu Unbiased forward genetics and systems biology approaches to understanding how gene-environment interactions work to predict susceptibility and outcomes of infections Discussion 11. Steven R. Kleeberger and Hye-Youn Cho Gene-environment interactions in environmental lung diseases Discussion General discussion III 12. Fernando D. Martinez Gene-environment interaction in complex diseases: asthma as an illustrative case Discussion 13. Michael Rutter Conclusions: taking stock and looking ahead Glossary Index of contributors Subject index