Pediatric Hematology 3e

Professor Robert Arceci is a world leader in the care of children with leukaemia and especially acute myeloid leukaemia. He edits the main Paediatric Haematology and Oncology journal, 'Pediatric Blood & Cancer' and his research is mainly into new agents for leukaemia therapy and the scientific basis for their actions. Professor Ian Hann is chair of the national NRCN task force on ALL. He is associate medical director of Great Ormond Street Hospital (GOS) and Professor and academic lead in Paediatric Haematology and Oncology at GOS and the Institute of Child Health. He coordinates the current national trial in ALL (ALL trial 2003) and is national coordinator of the international trial in infant leukaemia - Interfant. He is also Editor of the British Journal of Haematology. Professor Owen Smith is academic lead for Paediatric Haematology and Oncology at the National Children's Hospital and Trinity College, Dublin. He is a world expert on Shwachmann's syndrome and has carried out world-ranking research on protein C. He is national coordinator for UK and Ireland of the International relapsed AML trial.

Section 1: The Scientific Basis. 1 Hematopoiesis: an introduction (Hugh J.M. Brady). Section 2: Marrow Failure Syndromes. 2 Failure of red cell production (Sarah E. Ball). 3 Inherited bone marrow failure syndromes (Yigal Dror). 4 Acquired aplastic anemia (Juliana Teo and Yigal Dror). Section 3: Red Cell Disorders. 5 Disorders of iron metabolism: iron deficiency, iron overload and the sideroblastic anemias (Andrew M. Will). 6 Megaloblastic anemia and disorders of cobalamin and folate metabolism (Eric J. Werner). 7 Nonimmune neonatal anemias (Brenda E.S. Gibson and Christina Halsey). 8 Immune hemolytic anemias (Bertil Glader). 9 Disorders of erythrocyte metabolism including porphyria (Lawrence Wolfe and Peter E. Manley). 10 Sickle cell disease (Corrina McMahon). 11 Hemoglobin variants and the rarer hemoglobin disorders (Andreas E. Kulozik). 12 Red cell membrane abnormalities (Patrick G. Gallagher). 13 Thalassemias (Nancy F. Olivieri and David J. Weatherall). Section 4: Granulocyte Disorders. 14 Disorders of granulopoiesis and granulocyte function (Arian Laurence, Pratima Chowdary and Philip Ancliff). 15 Histiocytic disorders (Amir H. Shahlaee and Robert J. Arceci). 16 Acute myeloid leukemia (Leslie S. Kean, Robert J. Arceci and William G. Woods). 17 Chronic myeloid leukemia (Irene A.G. Roberts and Inderjeet S. Dokal). 18 Myelodysplastic syndromes (David K.H. Webb). Section 5: Lymphocyte Disorders. 19 Primary and acquired immunodeficiency (Andrew R. Gennery, Adam H.R. Finn and Andrew J. Cant). 20 Clinical features and therapy of lymphoblastic leukemia (Owen P. Smith and Ian M. Hann). 21 Lymphomas (O.B. Eden and Ross Pinkerton). Section 6: Platelet Disorders. 22 Inherited and congenital thrombocytopenia (Owen P. Smith). 23 Idiopathic thrombocytopenic purpura (Paul Imbach). 24 Thrombocytosis (Christof Dame). 25 Platelet function disorders (Alan D. Michelson). Section 7: Coagulation Disorders. 26 Hemophilia A and B (Judith Smith and Owen P. Smith). 27 von Willebrand disease (David Lillicrap). 28 Rare congenital hemorrhagic disorders (Nigel S. Key and Margaret A. Heisel-Kurth). 29 Acquired disorders of hemostasis (Elizabeth A. Chalmers, Michael D. Williams and Angela Thomas). 30 Bleeding in the neonate (Elizabeth A. Chalmers). 31 Thromboembolic complications in children (Mary Bauman and M. Patricia Massicotte). Section 8: Supportive Therapy. 32 Blood components and fractionated plasma products: preparation, indications and administration (Nancy Robitaille and Heather A. Hume). 33 Hazards of transfusion (Naomi L.C. Luban and Edward C.C. Wong). 34 Management of infection in children with bone marrow failure (Subarna Chakravorty and Ian M. Hann). Section 9: Secondary Problems. 35 Hematologic effects of systemic disease and nonhematopoietic tumors (Angela Thomas) 36 Lysosomal storage disorders (Brad T. Tinkle and Gregory A. Grabowski). 37 Reference values (Paula S. Simpkin and Roderick F. Hinchliffe). Index.