Pancreatic Cancer

John Neoptolemos is Professor of Surgery and Head of the Division of Surgery and Oncology at the University of Liverpool and Honorary Consultant Surgeon at the Royal Liverpool University Hospital. As an undergraduate he studied Natural Sciences at Cambridge (BA 1973, MA 1976) before completing his clinical undergraduate training at Guys Hospital (Cambridge: MB, BChir 1976). He completed his academic and clinical training in Leicester under Prof. Sir Peter Bell, being awarded a Doctorate in Medicine in 1986. Raul A. Urrutia, M.D., Mayo Clinic College of Medicine, Rochester, MN USA. Dr. Urrutia was awarded his M.D., Magna Cum Laude, by the University of Cordoba, Argentina. Dr. James L. Abbruzzese is the Chairman of the Department of Gastrointestinal Medical Oncology at the University of Texas M. D. Anderson Cancer Center, Houston, Texas, where he holds the Annie Laurie Howard Research Distinguished Professorship. Author of over 150 original articles and book chapters, Dr. Abbruzzese has recently been appointed the Editor-in-Chief of the International Journal of Pancreatology. He serves on the editorial board of a number of prestigious journals, including the Journal of Clinical Oncology and Clinical Cancer Research, and also serves on the Scientific Advisory Board of the Lustgarten Foundation for Pancreatic Cancer Research. Markus W. Büchler is Professor of Surgery at the University of Heidelberg, Germany. He studied medicine at the Universities of Heidelberg and Berlin and was trained in surgery at the Department of Surgery, University of Ulm, where he was appointed a Consultant Surgeon in 1987 and Vice Chairman in 1991. Professor Büchler is a specialist in hepato-pancreato-biliary surgery (HPB) and, in particular, pancreatic surgery. He has a substantial curriculum of scientific publications in the field of HPB diseases, especially in translational research of pancreatic cancer. He is Editor or Editorial Board member of many leading journals in general and gastrointestinal surgery, translational and molecular research in pancreatology and other gastrointestinal diseases, including Annals of Surgery, British Journal of Surgery. Digestive Surgery (Editor), Pancreas, Langenbeck's Archive of Surgery (Editor), HPB, and Surgery.

Section One: The Nature of Pancreatic Cancer














Epidemiology: world overview, risk factors, prospects for prevention







Development and structure of pancreas







Pathologic classification and biological behaviour of pancreatic neoplasia







Developmental molecular biology of the pancreas







Molecular pathology of precursor lesions of pancreatic cancer, pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), and mucinous cystic neoplasm (MCN)







Epigenetics: its fundamentals and applications to a revised comprehensive progression model for pancreatic cancer







Molecular pathology of pancreatic neuroendocrine tumours MEN-1: gastrinomas, insulinoma, Non-Functioning Tumours, VIPoma, glucagonoma, Von Hippel-Lindau, Neurofibromatosis







Sporadic neuroendocrine pancreatic tumours







Molecular pathology of non-pancreatic cancer lesions: Ampullary cancer, intra-pancreatic bile duct cancer, and duodenal cancer







Miscellaneous non-pancreatic non-endocrine tumours







Novel molecular relationships between chronic pancreatitis and cancer







Pancreatic cancer stem cells







Cell cycle control: signalling pathways in pancreatic pathogenesis







Apoptosis: signalling pathways in pancreatic pathogenesis







EGFR: signalling pathways in pancreatic pathogenesis Pl3, Akt, lKK, Ras, Raf, MAPKK, ERK







Hedgehog: signalling pathways in pancreatic pathogenesis







Smad4/TGF-ß pathway: signalling pathways in pancreatic pathogenesis







Notch signalling in pancreatic morphogenesis and pancreatic cancer







Molecular characterization of pancreatic cell lines







Mouse models of exocrine pancreatic cancer







Principles and applications of microarray gene expression in pancreatic cancer







Principles and applications of proteomics in pancreatic cancer







Tumour-stromal interaction: invasion and metastases







Genetic susceptibility, high risk groups, chronic and hereditary pancreatitis, familial pancreatic cancer syndromes







Inherited endocrine pancreatic tumors associated with Multiple Endocrine Neoplasia Type 1 Von-Hippel-Lindau Syndrome, and Neurofibromatosis Type 1









Section Two: Clinical Management of Pancreatic Cancer









Clinical decision making in pancreatic cancer







Paraneoplastic syndromes







Diagnostic and therapeutic response markers







CT and fusion PET-CT Diagnosis, staging, and follow-up







MRI and MRCP: diagnosis and staging of pancreatic cancer







EUS Diagnosis and staging







Laparoscopy and laparoscopic ultrasound: diagnosis and staging







Overview of palliative management for pancreatic cancer







Endoscopy.







Interventional radiology







Role of palliative surgery in advanced pancreatic cancer







Chemotherapy for advanced pancreatic cancer







Developments in chemoradiation in advanced pancreatic cancer







Surgical resection for pancreatic cancer







Role of venous resection in pancreatic cancer surgery







Pathological reporting and staging following resection







Japanese Pancreas Society staging for pancreatic cancer







Adjuvant chemotherapy in pancreatic cancer







Case for adjuvant chemoradiation therapy for pancreatic cancer







Case for neoadjuvant treatment in pancreatic cancer







Borderline resectable disease







Management of cystic neoplasms serous cystic neoplasms mucinous, cystic neoplasms, intraductal paillary mucinous neoplasms







Laparoscopic surgery for pancreatic neoplasm







Modern Japanese approach to pancreas cancer









Section Three: New Directions









Development of novel biomarkers







Inherited genetics of pancreatic cancer and secondary screening







Gene therapy for pancreatic cancer







Vaccine therapy and immunotherapy







Emerging targets in pancreatic cancer