Novartis Foundation Symposium 119 – Synth Peptides as Antigens

Ruth Porter is the editor of Synthetic Peptides as Antigens, published by Wiley. Julie Whelan is the editor of Synthetic Peptides as Antigens, published by Wiley.

Symposium on Synthetic Peptides as Antigens, held at the Ciba Foundation, London, 4 6 June 1985 The subject of this symposium was proposed by P. Dukor and D. G. Braun Editors: Ruth Porter (Organizer) and Julie Whelan G. L. Ada Introduction J. H. Humphrey Regulation of in vivo immune responses: few principles and much ignorance Discussion P. J. Lachmann, L. Strangeways, A. Vyakarnam and G. I. Evan Raising antibodies by coupling peptides to PPD and immunizing BCG-sensitized animals Discussion H. J. Dyson, K. J. Cross, J. Ostresh, R. A. Houghten, I. A. Wilson, P. E. Wright and R. A. Lerner Selection by site-directed antibodies of small regions of peptides which are ordered in water Discussion M. H. V. Van Regenmortel, D. Altschuh and A. Klug Influence of local structure on the location of antigenic determinants in tobacco mosaic virus protein Discussion M. J. Crumpton The importance of conformation and of equilibria in the interaction of globular proteins and their fragments with antibodies Discussion A. B. Edmundson and K. R. Ely Three-dimensional analyses of the binding of synthetic chemotactic and opioid peptides in the Mcg light chain dimer Discussion H. M. Geysen, S. J. Rodda and T. J. Mason The delineation of peptides able to mimic assembled epitopes Discussion V. Nussenzweig and R. S. Nussenzweig Experimental basis for the development of a synthetic vaccine against Plasmodium falciparum malaria sporozoites Discussion R. F. Anders, P-T. Shi, D. B. Scanlon, S. J. Leach, R. L. Coppel, G. V. Brown, H-D. Stahl and D. J. Kemp Antigenic repeat structures in proteins of Plasmodium falciparum Discussion M. Sela, R. Arnon and C. O. Jacob Synthetic peptides with antigenic specificity for bacterial toxins Discussion V. C. Stevens Use of synthetic peptides as immunogens for developing a vaccine against human chorionic gonadotropin Discussion D. R. Stanworth, D. S. Butt and G. Z. Hastings The use of synthetic peptides in the delineation of immunoglobulin antigenic epitopes and Fc effector functions Discussion G. I. Evan, D.C. Hancock, T. Littlewood and C. D. Pauza Characterization of the human c-myc protein using antibodies prepared against synthetic peptides Discussion S. S. Alkan and D. G. Braun Epitope mapping of human recombinant interferon alpha molecules by monoclonal antibodies Discussion Final general discussion Reactivity of anti-peptide antibodies with the parent proteins The proportion of monoclonal antibodies reactive to conformational or other linear sequences High and low affinity antibodies and their roles T-dependent and T-independent antigen presentation G. L. Ada Chairman's summing-up Index of contributors Subject index