Novartis Foundation Symposium 215 – Immunological Tolerance

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.

Introduction (Mitchison). Mechanisms of peripheral T cell tolerance (L. Parijs, et al.). B cell antigen receptor signalling in the balance of tolerance and immunity (Cirnall and FGoodnow). General discussion I. The study of self-tolerance using murine haemoglobin as a model self antigen (Williams and Allen). Tolerance and determinant hierarchy (Schnieder et al). Molecular genetic studies in lymphocyte apoptosis and human autoimmunity (Martin, et al.). General discussion II. A Role for CTLA-4-mediated inhibitory signals in peripheral T Cell tolerance? (Allison, et al). Antigen-specific CD4+ Tcells that survive after the induction of peripheral tolerance possess an intrinsic lymphokine production defect (pape et al). Antigen-specific tolerance induction and the immunotherapy of experimental autoimmunity disease (Anderton, et al.). Quantitative and qualitative control of antigen receptor signalling in tolerant B lymphocytes (Healy, et al.). Tolerance induction with CD4 monoclonal antibodies (Waldmann et al). Cross-presentation of self antigens to CD8+ Tcells: the balance between tolerance and autoimmunity (Kurts et al). General discussion III. Tolerance induction in mature T lymphocytes (Alferink, et al.). T lymphocyte-mediated control of autoimmunity (E. Shevach, et al.). Final General Discussion. Indexes.