Serotonin and Sleep: Molecular, Functional and Clinical Aspects

Evolution of concepts.- Changing concepts on the role of serotonin in the regulation of sleep and waking.- The dorsal raphe nucleus and median raphe nucleus: organization and projections.- Topographic organization and chemoarchitecture of the dorsal raphe nucleus and the median raphe nucleus.- Efferent and afferent connections of the dorsal and median raphe nuclei in the rat.- Reciprocal connections between the suprachiasmatic nucleus and the midbrain raphe nuclei: A putative role in the circadian control of behavioral states.- Serotonin receptors.- Localization of 5-HT receptors in the mammalian cortex.- Molecular biology of 5-HT receptors.- Electrophysiology of serotonergic neurons and the regulation of serotonin release.- Brain serotonergic neuronal activity in behaving cats.- Electrophysiological studies on serotonergic neurons and sleep.- Role and origin of the GABAergic innervation of dorsal raphe serotonergic neurons.- Regulation of serotonin release by inhibitory and excitatory amino acids.- Neurophysiological aspects of the regulation of serotonin neurons by the orexinergic system.- Serotonin receptors and the regulation of behavioural state.- Serotonin and dreaming.- Involvement of the 5-HT1A and the 5-HT1B receptor in the regulation of sleep and waking.- Mechanisms involved in the inhibition of REM sleep by serotonin.- Effect of 5-HT2A/2B/2C receptor agonists and antagonists on sleep and waking in laboratory animals and humans.- Effect of the selective activation of serotonin 5-HT3 receptors on sleep and waking.- 5-HT7 receptor modulation of sleep patterns.- Sleep and waking in mutant mice that do not express various proteins involved in serotonergic neurotransmission such as the serotonergic transporter, monoamine oxidase A, and 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT7 receptors.- Circadian control by serotonin and melatonin receptors: Clinical relevance.- Serotonergic mechanisms contributing to arousal and alerting.- Relevance of serotonin to clinical disorders and drug actions.- Contribution of chemosensitive serotonergic neurons to interactions between the sleep-wake cycle and respiratory control.- Obstructive sleep apnea: The potential for serotonergic pharmacotherapies.- The effects of antidepressant drugs and 5-HT1A agonists on human sleep.- The effect of typical and atypical antipsychotic drugs on sleep of schizophrenic patients.