Oxygen Biology and Hypoxia

Helmut Sies, MD, PhD (hon), studied medicine at the universities of Tübingen, Munich, and Paris. He was the professor and chair of the Institute for Biochemistry and Molecular Biology I at Heinrich-Heine-University Düsseldorf, Germany, where he is now professor emeritus. He is a member of the German National Academy of Sciences Leopoldina and was the president of the North Rhine-Westphalian Academy of Sciences and Arts. He was named ‘Redox Pioneer’; was the president of the Society for Free Radical Research International (SFRRI). Helmut Sies introduced the concept of “Oxidative Stress” in 1985, and was the first to reveal hydrogen peroxide as a normal constituent of aerobic cell metabolism. His research interests comprise redox biology, oxidants, antioxidants, micronutrients.

Section I. Hypoxia-inducible factor

Chapter 1
HIF PAS domains: structure and function
Thomas H. Scheuermann, Jinsong Yang, Lei Zhang, Kevin H. Gardner, and Richard K. Bruick

Chapter 2
Structure-function analysis of HIF
Lorenz Poellinger

Chaper 3
HIF Prolyl Hydroxylase: Purification and Assays of PHD2
Kirsty S. Hewitson, Christopher J. Schofield, Peter J. Ratcliffe

Chapter 4
Determination and modulation of prolyl-4-hydroxylase domain (PHD) oxygen sensor activity
Renato Wirthner, Kuppusamy Balamurugan, Daniel P. Stiehl, Sandra Barth, Patrick Spielmann, Felix Oehme, Ingo Flamme, Dörthe M. Katschinski, Roland H. Wenger and Gieri Camenisch

Chapter 5
Characterisation of ankyrin-repeat containing proteins as substrates of the asparaginyl hydroxylase Factor Inhibiting HIF (FIH-1).
Sarah Linke, Rachel J. Hampton-Smith, Daniel J. Peet

Chapter 6
Transgenic Models to Understand HIF Function
Andrew Doedens and Randall S. Johnson

Chapter 7
The Silencing Approach of the Hypoxia Signalling Pathway"
Edurne Berra and Jacques Pouyssegur

Chapter 8
Cellular and developmental adaptations to hypoxia; a Drosophila perspective
Nuria Magdalena Romero, Andrés Dekanty, Pablo Wappner

Section II. Erythropoietin

Chapter 9
Constitutively overexpressed erythropoietin reduces infarct size in a mouse model of permanent coronary artery ligation
Giovanni G. Camici, Thomas Stallmach, Matthias Hermann, Rutger Hassink, Peter Doevendans, Beat Grenacher, Alain Hirschy, Johannes Vogel, Thomas F. Lüscher, Frank Ruschitzka and Max Gassmann

Chapter 10
Control of erythropoietin gene expression and its use in medicine
Wolfgang Jelkmann

Chapter 11
Role of HIF-2 in endothelial development and hematopoiesis
Osamu Ohneda1,3, Masumi Nagano1,3 and Yoshiaki Fujii-Kuriyama

Section III. Hypoxia and adaptation

Chapter 12
ORGAN PROTECTION BY HYPOXIA AND HIF
Wanja M. Bernhardt, Christina Warnecke, Carsten Willam, Michael S. Wiesener and
Kai-Uwe Eckardt

Chapter 13
Hypoxia and regulation of mRNA translation
Marianne Koritzinsky and Bradly G. Wouters

Chapter 14
Hypoxia and the Unfolded Protein Response
Constantinos Koumenis, Meixia Bi, Jiangbin Ye, Douglas Feldman and Albert C. Koong

Section IV. Hypoxia and tumor biology

Chapter 15
Tumor hypoxia in cancer therapy
J. Martin Brown

Chapter 16
HIF Gene Expression in Cancer Therapy
By Denise A. Chan, Adam J. Krieg, Sandra Turcotte, and Amato J. Giaccia

Chapter 17
Analysis of HIF-1 Expression and Its Effects on Invasion and Metastasis
Balaji Krishnamachary, Gregg L. Semenza

Chapter 18
Macrophage migration inhibitory factor (MIF) manipulation and evaluation in tumoral hypoxic adaptation
Millicent Winner, Lin Leng, Wayne Zundel and Robert A. Mitchell

Chapter 19
The von Hippel-Lindau Tumor Suppressor Protein: An Update
William G. Kaelin, Jr.

Chapter 20
Hypoxia Inducible Factor 1 (HIF-1) inhibitors
Giovanni Melillo

Section V. Hypoxia and inflammatory mediators

Chapter 21
Regulation of HIF during Inflammation
Stilla Frede, Utta Berchner-Pfannschmidt, Joachim Fandrey

Chapter 22
Superoxide and derived reactive oxygen species in the regulation of hypoxia-inducible factors
Agnes Görlach, Thomas Kietzmann

Chapter 23
Genetics of mitochondrial electron transport chain in regulating oxygen sensing
Eric L. Bell and Navdeep S. Chandel

Chapter 24
Hypoxia inducible factor-1 (HIF-1) under the control of nitric oxide (NO)
Bernhard Brüne and Jie Zhou

Chapter 25
Hypoxic regulation of NF-κB signalling
Eoin P. Cummins, Katrina M. Comerford, Carsten Scholz, Ulrike Bruning & Cormac T. Taylor