Harrison's Principles of Internal Medicine (2 Vol Set)

Anthony S. Fauci, MDChief, Laboratory of ImmunoregulationDirector, National Institute of Allergy and Infectious DiseasesNational Institutes of Health. In 2008, Dr. Fauci was awarded the Presidential Medal of Freedom, the Nation's highest civil award. Among his many accomplishments, Dr. Braunwald is the editor of HEART DISEASE; a major competitor to HURST'S THE HEART and he is one of the primary editors of Harrison's PRINCIPLES OF INTERNAL MEDICINE. Dennis L. Kasper, MD, MA (Hon)William Ellery Channing Professor of MedicineProfessor of Microbiology and Molecular GeneticsExecutive Dean for Academic ProgramsHarvard Medical SchoolDirector, Channing LaboratoryDepartment of MedicineBrigham and Womens Hospital Stephen L. Hauser, MDChairman and Betty Anker Fife ProfessorDepartment of NeurologyUniversity of California, San Francisco Dan L. Longo, MDScientific DirectorNational Institute on AgingNational Institutes of HealthBethesda, Maryland C.F. Kettering Professor of Medicine, Chief, Division of Endocrinology, Metabolism and Molecular Medicine Northwestern University Medical School, Chicago, IL. Hersey Professor of the Theory and Practice of Medicine, Harvard Medical School; Chairman, Department of Medicine; Physician-in-Chief, Brigham and Womens Hospital, Boston, Massachusetts

Contents

Contributors

Preface

PART 1:

Introduction to Clinical Medicine

1The Practice of Medicine
The Editors

2Global Issues in Medicine
Jim Yong Kim / Paul Farmer

3Decision-Making in Clinical Medicine
Daniel B. Mark

4Screening and Prevention of Diseases
Gary J. Martin

5Principles of Clinical Pharmacology
Dan M. Roden

6Women's Health
Andrea Dunaif

7Medical Disorders during Pregnancy
Robert L. Barbieri / John T. Repke

8Medical Evaluation of the Surgical Patient
Wei C. Lau / Kim A. Eagle

9Geriatric Medicine
Lisa B. Caruso / Rebecca A. Silliman

10Complementary and Alternative Medicine
Stephen E. Straus

11Palliative and End-of-Life Care
Ezekiel J. Emanuel / Joshua Hauser / Linda L. Emanuel

e1The Safety and Quality of Health Care
David W. Bates

e2Economic Considerations in the Practice of Medicine
David Meltzer

e3Racial and Ethnic Disparities in Health Care
Joseph R. Betancourt / David Blumenthal

e4Ethical Issues in Clinical Medicine
Bernard Lo

PART 2:

Cardinal Manifestations and Presentation of Diseases

Section 1: Pain

12Pain: Pathophysiology and Management
Howard L. Fields / Joseph B. Martin

13Chest Discomfort
Thomas H. Lee

14Abdominal Pain
William Silen

15Headache
Peter J. Goadsby / Neil H. Raskin

16Back and Neck Pain
John W. Engstrom

Section 2:

Alterations in Body Temperature

17Fever and Hyperthermia
Charles A. Dinarello / Reuven Porat

18Fever and Rash
Elaine T. Kaye / Kenneth M. Kaye

e5Atlas of Rashes Associated with Fever
Kenneth M. Kaye / Elaine T. Kaye

19Fever of Unknown Origin
Jeffery A. Gelfand / Michael V. Callahan

20 Hypothermia and Frostbite
Daniel F. Danzl

Section 3:

Nervous System Dysfunction

21Syncope
Mark D. Carlson

22Dizziness and Vertigo
Robert B. Daroff

23Weakness and Paralysis
Michael J. Aminoff

24Gait and Balance Disorders
Lewis Sudarsky

25Numbness, Tingling, and Sensory Loss
Michael J. Aminoff / Arthur K. Asbury

26Confusion and Delirium
S. Andrew Josephson / Bruce L. Miller

e6Memory Loss
Thomas D. Bird / Bruce L. Miller

27Aphasia, Memory Loss, and Other Focal Cerebral Disorders
M.-Marsel Mesulam

28Sleep Disorders
Charles A. Czeisler / John W. Winkelman / Gary S. Richardson

Section 4:

Disorders of Eyes, Ears, Nose, and Throat

29Disorders of the Eye
Jonathan C. Horton

30Disorders of Smell, Taste, and Hearing
Anil K. Lalwani

31Pharyngitis, Sinusitis, Otitis, and Other Upper Respiratory Tract Infections
Michael A. Rubin / Ralph Gonzales / Merle A. Sande

32Oral Manifestations of Disease
Samuel C. Durso

e7Atlas of Oral Manifestations of Disease
Samuel C. Durso / Janet A. Yellowitz / Jane C. Atkinson

Section 5:

Alterations in Circulatory and Respiratory Functions

33Dyspnea and Pulmonary Edema
Richard M. Schwartzstein

34Cough and Hemoptysis
Steven E. Weinberger / David A. Lipson

35Hypoxia and Cyanosis
Eugene Braunwald

36Edema
Eugene Braunwald / Joseph Loscalzo

e8Approach to the Patient with a Heart Murmur
Patrick T. O'Gara / Eugene Braunwald

37Palpitations
Joseph Loscalzo

Section 6:

Alterations in Gastrointestinal Function

38Dysphagia
Raj K. Goyal

39Nausea, Vomiting, and Indigestion
William L. Hasler

40Diarrhea and Constipation
Michael Camilleri / Joseph A. Murray

41Weight Loss
Carol M. Reife

42Gastrointestinal Bleeding
Loren Laine

43Jaundice
Daniel S. Pratt / Marshall M. Kaplan

44Abdominal Swelling and Ascites
Robert M. Glickman / Roshini Rajapaksa

Section 7:

Alterations in Renal and Urinary Tract Function

45Azotemia and Urinary Abnormalities
Bradley M. Denker / Barry M. Brenner

e9Atlas of Urinary Sediments and Renal Biopsies
Agnes B. Fogo / Eric G. Neilsen

46Fluid and Electrolyte Disturbances
Gary G. Singer / Barry M. Brenner

47Hypercalcemia and Hypocalcemia
Sundeep Khosla

48Acidosis and Alkalosis
Thomas B. DuBose, Jr.

Section 8:

Alterations in Sexual Function and Reproduction

49Sexual Dysfunction
Kevin T. McVary

50Hirsutism and Virilization
David A. Ehrmann

51Menstrual Disorders and Pelvic Pain
Janet E. Hall

Section 9: Alterations in the Skin

52Approach to the Patient with a Skin Disorder
Thomas J. Lawley / Kim B. Yancey

53Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders
Calvin O. McCall / Thomas J. Lawley

54Skin Manifestations of Internal Disease
Jean L. Bolognia / Irwin M. Braverman

55Immunologically Mediated Skin Diseases
Kim B. Yancey / Thomas J. Lawley

56Cutaneous Drug Reactions
Jean-Claude Roujeau / Robert S. Stern / Bruce C. Wintroub

57Photosensitivity and Other Reactions to Light
David R. Bickers

e10Atlas of Skin Manifestations of Internal Disease
Thomas J. Lawley / Stephen Templeton

Section 10:

Hematologic Alterations

58Anemia and Polycythemia
John W. Adamson / Dan L. Longo

59Bleeding and Thrombosis
Barbara A. Konkle

60Enlargement of Lymph Nodes and Spleen
Patrick H. Henry / Dan L. Longo

61Disorders of Granulocytes and Monocytes
Steven M. Holland /John I. Gallin

e11Atlas of Hematology and Analysis of Peripheral Blood Smears
Dan L. Longo

PART 3: Genetics and Disease

62Principles of Human Genetics
J. Larry Jameson / Peter Kopp

63Chromosome Disorders
Terry J. Hassold / Stuart Schwartz

64The Practice of Genetics in Clinical Medicine
Susan Miesfeldt / J. Larry Jameson

65Gene Therapy in Clinical Medicine
Katherine A. High

PART 4:

Regenerative Medicine

66Stem Cell Biology
Minoru S. H. Ko

67Applications of Stem Cell Biology in Clinical Medicine
Jack A. Kessler

68Hematopoietic Stem Cells
David T. Scadden / Dan L. Longo

69Tissue Engineering
Jennifer Anderson /Joseph P. Vacanti

PART 5: Nutrition

70Nutritional Requirements and Dietary Assessment
Johanna Dwyer

71Vitamin and Trace Mineral Deficiency and Excess
Robert M. Russell / Paolo M. Suter

72Malnutrition and Nutritional Assessment
Douglas C. Heimburger

73Enteral and Parenteral Nutrition Therapy
Bruce R. Bistrian / David F. Driscoll

74Biology of Obesity
Jeffrey S. Flier / Eleftheria Maratos-Flier

75Evaluation and Management of Obesity
Robert F. Kushner

76Eating Disorders
B. Timothy Walsh

PART 6: Oncology and Hematology

Section 1: Neoplastic Disorders

77Approach to the Patient with Cancer
Dan L. Longo

78Prevention and Early Detection of Cancer
Otis W. Brawley / Barnett S. Kramer

79Cancer Genetics
Pat J. Morin / Jeffrey M. Trent / Francis S. Collins / Bert Vogelstein

80Cancer Cell Biology and Angiogenesis
Robert G. Fenton / Dan L. Longo

81Principles of Cancer Treatment
Edward A. Sausville / Dan L. Longo

82Infections in Patients with Cancer
Robert Finberg

83Cancer of the Skin
Arthur J. Sober / Hensin Tsao / Carl V. Washington

84Head and Neck Cancer
Everett E. Vokes

85Neoplasms of the Lung
John D. Minna / Joan H. Schiller

86Breast Cancer
Marc E. Lippman

87Gastrointestinal Tract Center
Robert J. Mayer

88Tumors of the Liver and Biliary Tree
Brian I. Carr

89Pancreatic Cancer
Yu Jo Chua / David Cunningham

90Bladder and Renal Cell Carcinomas
Howard I. Scher / Robert J. Motzer

91Benign and Malignant Diseases of the Prostate
Howard I. Scher

92Testicular Cancer
Robert J. Motzer / George J. Bosl

93Gynecologic Malignancies
Robert C. Young

94Soft Tissue and Bone Sarcomas and Bone Metastases
Shreyaskumar R. Patel / Robert S. Benjamin

95Carcinoma of Unknown Primary
Gauri R. Varadhachary /James L. Abbruzzese

96Paraneoplastic Syndromes: Endocrinologic/Hematologic
J. Larry Jameson / Bruce E. Johnson

97Paraneoplastic Neurologic Syndromes
Josep Dalmau / Myrna R. Rosenfeld

e12Thymoma
Dan L. Longo

e13Late Consequences of Cancer and Its Treatment
Michael C. Perry / Dan L. Longo

Section 2: Hematopoietic Disorders

98Iron Deficiency and Other Hypoproliferative Anemias
John W. Adamson

99Disorders of Hemoglobin
Edward J. Benz, Jr.

100Megaloblastic Anemias
A. Victor Hoffbrand

101Hemolytic Anemias and Anemia Due to Acute Blood Loss
Lucio Luzzatto

102Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes
Neal S. Young

103Polycythemia Vera and Other Myeloproliferative Diseases
Jerry L. Spivak

104Acute and Chronic Myeloid Leukemia
Meir Wetzler /John C. Byrd / Clara D. Bloomfield

105Malignancies of Lymphoid Cells
Dan L. Longo

106Plasma Cell Disorders
Nikhil C. Munshi / Dan L. Longo / Kenneth C. Anderson

107Transfusion Biology and Therapy
Jeffery S. Dzieczkowski / Kenneth C. Anderson

108Hematopoietic Cell Transplantation
Frederick R. Applebaum

Section 3: Disorders of Hemostasis

109Disorders of Platelets and Vessel Wall
Barbara A. Konkle

110Coagulation Disorders
Valder Arruda / Katherine A. High

111Venous Thrombosis
F.R. Rosendaal / H.R. Buller

112Antiplatelet, Anticoagulant, and Fibrinolytic Drugs
Jeffery I. Weitz

PART 7: Infectious Diseases

Section 1: Basic Considerations in Infectious Diseases

113Introduction to Infectious Diseases: Host-Pathogen Interactions
Lawrence C. Madoff / Dennis L. Kasper

114Molecular Mechanisms of Microbial Pathogenesis
Gerald B. Pier

115Approach to the Acutely Ill Infected Febrile Patient
Tamar F. Barlam / Dennis L. Kasper

116Immunization Principles and Vaccine Use
Gerald T. Keusch / Kenneth J. Bart / Mark Miller

117Health Advice for International Travel
J.S. Keystone / Phyllis E. Kozarsky

e14Laboratory Diagnosis of Infectious Diseases
Alexander J. McAdam / Andrew B. Onderdonk

Section 2: Clinica
l Syndromes: Community-Acquired Infections

118Infective Endocarditis
Adolf W. Karchmer

119Infections of the Skin, Muscle, and Soft Tissues
Dennis L. Stevens

120Osteomyelitis
Jeffrey Parsonnet

121Intraabdominal Infections and Abscesses
Miriam J. Baron / Dennis L. Kasper

122 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning
Joan R. Butterton / Stephen B. Calderwood

123Clostridium difficile-Associated Disease, Including Pseudomembranous Colitis
Dale N. Gerding / Stuart Johnson

124Sexually Transmitted Infections: Overview and Clinical Approach
King K. Holmes

e15Infectious Complications of Burns and Bites
Lawrence C. Madoff / Florencia Pereyra

Section 3: Clinical Syndromes: Health Care-Associated Infections

125Health Care-Associated Infections
Robert A. Weinstein

126Infections in Transplant Recipients
Robert Finberg /Joyce Fingeroth

Section 4: Approach to Therapy for Bacterial Diseases

127Treatment and Prophylaxis of Bacterial Infections
Gordon L. Archer / Ronald E. Polk

Section 5: Diseases Caused by Gram-Positive Bacteria

128Pneumococcal Infections
Daniel M. Musher

129Staphylococcal Infections
Franklin D. Lowy

130Streptococcal and Enterococcal Infections
Michael R. Wessels

131Diphtheria and Other Infections Caused by Corynebacteria and Related Species
William R. Bishai / John R. Murphy

132Infections Caused by Listeria monocytogenes
Elizabeth L. Hohmann / Daniel A. Portnoy

133Tetanus
Elias Abrutyn

134Botulism
Elias Abrutyn

135Gas Gangrene and Other Clostridial Infections
Dennis L. Kasper /Lawrence C. Madoff

Section 6: Diseases Caused by Gram-Negative Bacteria

136Meningococcal Infections
Lee M. Wetzler

137Gonococcal Infections
Sanjay Ram / Peter A. Rice

138Moraxella Infections
Daniel M. Musher

139Haemophilus Infections
Timothy F. Murphy

140Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria
Tamar F. Barlam / Dennis L. Kasper

141Legionella Infection
Miguel Sabria / Victor L. Yu

142Pertussis and Other Bordetella Infections
Scott A. Halperin

143Diseases Caused by Gram-Negative Enteric Bacilli
Thomas A. Russo / James R. Johnson

144Helicobacter pylori Infections
John C. Atherton / Martin J. Blaser

145Infections Due to Pseudomonas Species and Related Organisms
Reuben Ramphal

146Salmonellosis
David A. Pegues / Samuel I. Miller

147Shigellosis
Philippe Sansonetti / Jean Bergounioux

148Infections Due to Campylobacter and Related Species
Martin J. Blaser

149Cholera and Other Vibrioses
Matthew K. Waldor / Gerald T. Keusch

150Brucellosis
Michael J. Corbel / Nicholas J. Beeching

151Tularemia
Richard F. Jacobs / Gordon E. Schutze

152Plague and Other Yersinia Infections
David T. Dennis / Grant L. Campbell

153Bartonella Infections, Including Cat-Scratch Disease
David H. Spach / Emily Darby

154Donovanosis
Gavin Hart

Section 7: Miscellaneous Bacterial Infections

155Nocardiosis
Gregory A. Filice

156Actinomycosis
Thomas A. Russo

157Infections Due to Mixed Anaerobic Organisms
Dennis L. Kasper / Ronit Cohen-Poradosu

Section 8: Mycobacterial Diseases

158Tuberculosis
Mario C. Raviglione / Richard J. O'Brien

159Leprosy (Hansen's Disease)
Robert H. Gelber

160Nontuberculous Mycobacteria
C. Fordham von Reyn

161Antimycobacterial Agents
Richard J. Wallace, Jr. / David E. Griffith

Section 9: Spirochetal Disease

162Syphilis
Sheila A. Lukehart

163Endemic Treponematoses
Sheila A. Lukehart

164Leptospirosis
Peter Speelman / Rudy Harkskeerl

165Relapsing Fever
David T. Dennis

166Lyme Borreliosis
Allen C. Steere

Section 10: Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae

167Rickettsial Diseases
David H. Walker / J. Stephen Dumler / Thomas Marrie

168Infections Due to Mycoplasmas
William M. McCormack

169Chlamydial Infections
Walter E. Stamm

Section 11: Viral Diseases: General Considerations

170Medical Virology
Fred Wang /Elliott Kieff

171Antiviral Chemotherapy, Excluding Antiretroviral Drugs
Lindsey R. Baden / Raphael Dolin

Section 12: Infections Due to DNA Viruses

172Herpes Simplex Viruses
Lawrence Corey

73Varicella-Zoster Virus Infections
Richard J. Whitley

174Epstein-Barr Virus Infections, Including Infectious Mononucleosis
Jeffry I. Cohen

175Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8
Martin S. Hirsch

176Molluscum Contagiosum, Monkeypox, and Other Poxviruses, Excluding Smallpox Virus
Fred Wang

177Parvovirus Infections
Kevin E. Brown

178Human Papillomavirus Infections
Richard C. Reichman

Section 13: Infections Due to DNA and RNA Respiratory Viruses

179Common Viral Respiratory Infections and Severe Acute Respiratory Syndrome (SARS)
Raphael Dolin

180Influenza
Raphael Dolin

Section 14: Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses

181The Human Retroviruses
Dan L. Longo /Anthony S. Fauci

182Human Immunodeficiency Virus Disease: AIDS and Related Disorders
Anthony S. Fauci / H. Clifford Lane

Section 15: Infections Due to RNA Viruses

183Viral Gastroenteritis
Umesh D. Parashar / Roger I. Glass

184Enteroviruses and Reoviruses
Jeffery I. Cohen

185Measles (Rubeola)
Anne Gershon

186Rubella (German Measles)
Anne Gershon

187Mumps
Anne Gershon

188Rabies and Other Rhabdovirus Infections
Alan C. Jackson / Eric C. Johannsen

189Infections Caused by Arthropod- and Rodent-Borne Viruses
Clarence J. Peters

190Ebola and Marburg Viruses
Clarence J. Peters

Section 16: Fungal and Algal Infections

191Diagnosis and Treatment of Fungal Infections
John E. Edwards, Jr.

192Histoplasmosis
Chadi A. Hage / L. Joseph Wheat

193Coccidioidomycosis
Neil M. Ampel

194Blastomycosis
Stanley W. Chapman / Donna C. Sullivan

195Cryptococcosis
Arturo Casadevall

196Candidiasis
John E. Edwards, Jr.

197Aspergillosis
David W. Denning

198Mucormycosis
Alan M. Sugar

199Miscellaneous Mycoses and Algal Infections
Stanley W. Chapman / Donna C. Sullivan

200Pneumocystis Infection
A. Geroge Smulian /Peter D. Walzer

Section 17: Protozoal and Helminthic Infections: General Considerations

e16Laboratory Diagnosis of Parasitic Infections
Sharon L. Reed / Charles E. Davis

201Agents Used to Treat Parasitic Infections
Thomas A. Moore

e17Pharmacology of Agents Used to Treat Parasitic Infections
Thomas A. Moore

Section 18: Protozoal Infections

202Amebiasis and Infection with Free-Living Amebas
Sharon L. Reed

203Malaria
Nicholas J. White / Joel G. Breman

204Babesiosis
Jeffry Gelfand / Edouard Vannier

e18Atlas of Blood Smears of Malaria and Babesiosis
Nicholas J. White / Joel G. Breman

205Leishmaniasis
Barbara L. Herwaldt

206Trypanosomiasis
Louis V. Kirchhoff

207Toxoplasma Infections
Lloyd H. Kasper

208Protozoal Intestinal Infections and Trichomoniasis
Peter F. Weller

Section 19: Helminthic Infections

209Trichinella and Other Tissue Nematodes
Peter F. Weller

210Intestinal Nematodes
Peter F. Weller /Thomas B. Nutman

211Filarial and Related Infections
Thomas B. Nutman / Peter F. Weller

212Schistosomiasis and Other Trematode Infections
Adel A.F. Mahmoud

213Cestodes
A. Clinton White, Jr. / Peter F. Weller

PART 8: Bioterrorism and Clinical Medicine

214Microbial Bioterrorism
H. Clifford Lane / Anthony S. Fauci

215Chemical Bioterrorism
Charles G. Hurst / Jonathan Newmark / James A. Romano, Jr.

216Radiation Bioterrorism
Zelig A. Tochner / Eli Glatstein

PART 9: Disorders of the Cardiovascular System

Section 1: Introduction to Cardiovascular Disorders

217Basic Biology of the Cardiovascular System
Joseph Loscalzo / Peter Libby / Eugene Braunwald

218Epidemiology of Cardiovascular Disease
Thomas A. Gaziano / J. Michael Gaziano

219Approach to the Patient with Possible Cardiovascular Disease
Eugene Braunwald

Section 2: Diagnosis of Cardiovascular Disorders

220Physical Examination of the Cardiovascular System
Robert A. O'Rourke /Eugene Braunwald

221Electrocardiography
Ary L. Goldberger

e19Atlas of Electrocardiography
Ary L. Goldberger

222Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and MRI/CT Imaging
Rick A. Nishimura / Raymond J. Gibbons / James F. Glockner /A. Jamil Tajik

e20Atlas of Noninvasive Cardiac Imaging
Rick A. Nishimura / Raymond J. Gibbons / James F. Glockner / A. Jamil Tajik

223Diagnostic Cardiac Catheterization and Angiography
Donald S. Baim

Section 3: Disorders of Rhythm

224Principles of Electrophysiology
Gordon F. Tomaselli

225The Bradyarrhythmias
Gordon F. Tomaselli

226The Tachyarrhythmias
Francis Marchlinksi

e21Atlas of Cardiac Arrhythmias
Ary L. Goldberger

Section 4: Disorders of the Heart

227Heart Failure and Cor Pulmonale
Douglas L. Mann

228Cardiac Transplantation and Prolonged Assisted Circulation
Sharon A. Hunt

229Congenital Heart Disease in the Adult
John S. Child

230Valvular Heart Disease
Patrick O'Gara / Eugene Braunwald

231Cardiomyopathy and Myocarditis
Joshua Wynne / Eugene Braunwald

232Pericardial Disease
Eugene Braunwald

233Tumors and Trauma of the Heart
Eric H. Awtry / Wilson S. Colucci

234Cardiac Manifestations of Systemic Disease
Eric H. Awtry / Wilson S. Colucci

Section 5: Vascular Disease

235The Pathogenesis, Prevention, and Treatment of Atherosclerosis
Peter Libby

e22Atlas of Atherosclerosis
Peter Libby

236The Metabolic Syndrome
Robert H. Eckel

237I
schemic Heart Disease
Elliott M. Antman / Andrew P. Selwyn/ Eugene Braunwald / Joseph Loscalzo

238Unstable Angina and Non-ST-Elevation Myocardial Infarction
Christopher P. Cannon / Eugene Braunwald

239ST-Segment Elevation Myocardial Infarction
Elliott M. Antman / Eugene Braunwald

240Percutaneous Coronary Intervention
Donald S. Baim

e23Atlas of Percutaneous Revascularization
Donald S. Baim

241Hypertensive Vascular Disease
Ted A. Kotchen

242Diseases of the Aorta
Mark A. Creager / Joseph Loscalzo

243Vascular Diseases of the Extremities
Mark A. Creager / Joseph Loscalzo

244Pulmonary Hypertension
Stuart Rich

PART 10: Disorders of the Respiratory System

Section 1: Diagnosis of Respiratory Disorders

245Approach to the Patient with Disease of the Respiratory System
David A. Lipson / Steven E. Weinberger

246Disturbances of Respiratory Function
Steven E. Weinberger /Ilene M. Rosen

247Diagnostic Procedures in Respiratory Diseases
Scott Manaker / Steven E. Weinberger

e24Atlas of Chest Imaging
Patricia A. Kritek / John J. Reilly, Jr.



248Asthma
Peter J. Barnes

249Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia
Joel N. Kline / Gary W. Hunninghake

250Environmental Lung Disease
Frank E. Speizer / John R. Balmes

251Pneumonia
Lionel A. Mandell / Richard Wunderink

252Bronchiectasis and Lung Abscess
Gregory Tino / Steven E. Weinberger

253Cystic Fibrosis
Richard C. Boucher

254Chronic Obstructive Pulmonary Disease
John J. Reilly, Jr. / Edwin K. Silverman / Steven D. Shapiro

255Interstitial Lung Diseases
Talmadge E. King, Jr.

256Deep Venous Thrombosis and Pulmonary Thromboembolism
Samuel Z. Goldhaber

257Disorders of the Pleura and Mediastinum
Richard W. Light

258Disorders of Ventilation
Eliot A. Phillipson

259Sleep Apnea
Neil J. Douglas

260Lung Transplantation
Elbert P. Trulock

PART 11: Critical Care Medicine

Section 1: Respiratory Critical Care

261Principles of Critical Care Medicine
John P. Kress / Jesse B. Hall

262Acute Respiratory Distress Syndrome
Bruce D. Levy / Steve D. Shapiro

263Mechanical Ventilatory Support
Edward P. Ingenito

Section 2: Shock and Cardiac Arrest

264Approach to the Patient with Shock
Ronald V. Maier

265Severe Sepsis and Septic Shock
Robert S. Munford

266Cardiogenic Shock and Pulmonary Edema
Judith S. Hochman / David H. Ingbar

267Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death
Robert J. Myerberg / Agustin Castellanos

Section 3: Neurologic Critical Care

268Coma
Allan H. Ropper

269Neurologic Critical Care, Including Hypoxic-Ischemic Encephalopathy and Subarachnoid Hemorrhage
J. Claude Hemphill, III / Wade S. Smith

Section 4: Oncologic Emergencies

270Oncologic Emergencies
Rasim Gucalp / Janice P. Dutcher

PART 12: Disorders of the Kidney and Urinary Tract

271Cellular and Molecular Biology of the Kidney
Alfred L. George, Jr. / Eric G. Neilson

272Adaptation of the Kidney to Renal Injury
Raymond C. Harris / Eric G. Neilson

273Acute Renal Failure
Kathleen D. Liu / Glenn M. Chertow

274Chronic Kidney Disease
Joanne M. Bargman / Karl Skorecki

275Dialysis in the Treatment of Renal Failure
Kathleen D. Liu / Glenn M. Chertow

276Transplantation in the Treatment of Renal Failure
Charles B. Carpenter / Edgar L. Milford / Mohamed H. Sayegh

277Glomerular Diseases
Julia B. Lewis / Eric G. Neilson

278Polycystic Kidney Disease and Other Inherited Tubular Disorders
David J. Salant / Parul S. Patel

279Tubulointerstitial Diseases of the Kidney
Alan S. L. Yu / Barry M. Brenner

280Vascular Injury to the Kidney
Kamal F. Badr / Barry M. Brenner

281Nephrolithiasis
John R. Asplin / Fredric L. Coe / Murray J. Favus

282Urinary Tract Infections, Pyelonephritis, and Prostatitis
Walter E. Stamm

283Urinary Tract Obstruction
Julian L. Seifter / Barry M. Brenner

PART 13: Disorders of the Gastrointestinal System

Section 1: Disorders of the Alimentary Tract

284Approach to the Patient with Gastrointestinal Disease
William L. Hasler / Chung Owyang

285Gastrointestinal Endoscopy
Louis Michel Wong-Kee-Song / Mark Topazian

e25Video Atlas of Gastrointestinal Endoscopy
Louis Michel Wong-Kee-Song / Mark Topazian

286Diseases of the Esophagus
Raj. K. Goyal

287Peptic Ulcer Disease and Related Disorders
John Del Valle

288Disorders of Absorption
Henry J. Binder

289Inflammatory Bowel Disease
Sonia Friedman / Richard S. Blumberg

290Irritable Bowel Syndrome
Chung Owyang

291Diverticular Disease and Common Anorectal Disorders
Susan L. Gearhart

292Mesenteric Vascular Insufficiency
Susan L. Gearhart

293Acute Intestinal Obstruction
Susan L. Gearhart / William Silen

294Acute Appendicitis and Peritonitis
Susan L. Gearhart / William Silen

Section 2: Liver and Biliary Tract Disease

295Approach to the Patient with Liver Disease
Marc Ghany /Jay H. Hoofnagle

296Evaluation of Liver Function
Daniel S. Pratt / Marshall M. Kaplan

297The Hyperbilirubinemias
Allan W. Wolkoff

298Acute Viral Hepatitis
Jules L. Dienstag

299Toxic and Drug-Induced Hepatitis
Jules L. Dienstag

300Chronic Hepatitis
Jules L. Dienstag

301Alcoholic Liver Disease
Mark E. Mailliard / Michael F. Sorrell

302Cirrhosis and Its Complications
Bruce R. Bacon

e26Atlas of Liver Biopsies
Jules L. Dienstag / Atul K. Bhan

303Genetic, Metabolic, and Infiltrative Diseases Affecting the Liver
Bruce R. Bacon

304Liver Transplantation
Jules L. Dienstag /Raymond T. Chung

305Diseases of the Gallbladder and Bile Ducts
Norton J. Greenberger / Gustav Paumgartner

Section 3: Disorders of the Pancreas

306Approach to the Patient with Pancreatic Disease
Phillip P. Toskes / Norton J. Greenberger

307Acute and Chronic Pancreatitis
Norton J. Greenberger / Phillip P. Toskes

PART 14: Disorders of the Immune System, Connective Tissue, and Joints

Section 1: The Immune System in Health and Disease

308Introduction to the Immune System
Barton F. Haynes / Kelly A. Soderberg / Anthony S. Fauci

309The Major Histocompatability Complex
Gerald T. Nepom

310Primary Immune Deficiency Diseases
Max D. Cooper / Harry W. Schroeder, Jr.

e27Primary Immunodeficiencies Associated with or Secondary to Other Diseases
Max D. Cooper / Harry W. Schroeder, Jr.

Section 2: Disorders of Immune-Mediated Injury

311Allergies, Anaphylaxis, and Systemic Mastocytosis
K. Frank Austen

312Autoimmunity and Autoimmune Diseases
Peter E. Lipsky / Betty Diamond

313Systemic Lupus Erythematosus
Bevra Hannahs Hahn

314Rheumatoid Arthritis
Peter E. Lipsky

315Acute Rheumatoid Fever
Jonathan R. Carapetis

316Systemic Sclerosis (Scleroderma) and Related Disorders
John Varga

317Sjoegren's Syndrome
Haralampos M. Moutsopoulos

318The Spondyloarthritides
Joel D. Taurog

319The Vasculitis Syndromes
Carol A. Langford / Anthony S. Fauci

e28Atlas of Clinical Imaging of the Vasculitic Diseases
Carol A. Langford / Anthony S. Fauci

320Behcet's Syndrome
Haralampos M. Moutsopoulos

321Relapsing Polychondritis
Carol A. Langford /Bruce C. Gilliland

322Sarcoidosis
Robert P. Baughman /Elyse E. Lower

323Familial Mediterranean Fever
Daniel L. Kastner

324Amyloidosis
David C. Seldin / Martha Skinner

Section 3: Disorders of the Joints and Adjacent Tissues

325Approach to Articular and Musculoskeletal Disorders
John J. Cush / Peter E. Lipsky

326Osteoarthritis
David T. Felson

327Gout and Other Crystal Arthropathies
H. Ralph Schumacher / Lan X. Chen

328Infectious Arthritis
Lawrence C. Madoff

329Fibromyalgia
Carol A. Langford /Bruce C. Gilliland

330Arthritis Associated with Systemic Disease and Other Arthritides
Carol A. Langford / Bruce C. Gilliland

331Periarticular Disorders of the Extremities
Carol A. Langford / Bruce C. Gilliland

PART 15: Endocrinology and Metabolism

Section 1: Endocrinology

332Principles of Endocrinology
J. Larry Jameson

333Disorders of the Anterior Pituitary and Hypothalamus
Shlomo Melmed / J. Larry Jameson

334Disorders of the Neurohypophysis
Gary L. Robertson

335Disorders of the Thyroid Gland
J. Larry Jameson / Anthony P. Weetman

336Disorders of the Adrenal Cortex
Gordon H. Williams / Robert G. Dluhy

337Pheochromocytoma
Hartmut P.H. Neumann

338Diabetes Mellitus