Pediatric Cardiovascular Medicine

Julien I E Hoffman, M.D., F.R.C.P (London) was born and educated in Salisbury (now Harare) in Southern Rhodesia (now Zimbabwe). He received a Bsc (Hons) in 1945 from the University of the Witwatersrand in South Africa, and his M.B., B.Ch. degree there in 1949. After working in the Departments of Medicine in Johannesburg General Hospital and in the Central Middlesex Hospital in London, he worked for the Medical Research Council at the Royal Postgraduate School in Hammersmith, London. Then he spent two years training in Pediatric Cardiogy at Boston Children's Hospital, followed by 15 months as a Fellow at the Cardiovascular Research Institute (CVRI) at the University of California in San Francisco (UCSF). In 1962 he joined the faculty of the Albert Einstein College of Medicine in New York, and moved in 1966 to UCSF as Associate Professor of Pediatrics and member of the CVRI. He spent 50% of his time in the care of children with heart disease and 50% of his time doing research into the pathophysiology of the coronary circulation. His interest in Statistics began while taking his Science degree. In England, he took a short course run by Bradford Hill. On returning to Johannesburg he was assigned to statistical analyses for other members of the Department of Medicine. Learning was by trial and error, helped by Dr J Kerrich, head of the University's Statistics Department. Hoffman began teaching statistics to Medical students in 1964, and in San Francisco conducted an approved course for Fellows and Residents for over 30 years. He was a member of the Biostatistics group for approving and coordinating statistics at UCSF. For many years he was a statistical consultant for the journal Circulation Research, and was intermittently statistical consultant to several other medical journals.

Section I Scientific Background Chapter 1 Development Chapter 2 Genetic Control in Pediatric Cardiovascular Medicine Chapter 3 Cardiac Physiology and Myocardial Function Chapter 4 The Fetal Circulation and its Adjustments after Birth Chapter 5 Cardiac Function Chapter 6 Physiology and Pathophysiology of Myocardial Blood Flow Chapter 7 Control of Pulmonary Vasculature Section II Diagnostic Methods Chapter 8 Examination Chapter 9 Electrocardiography Chapter 10 Plan Film Diagnosis of Congenital Heart Disease Chapter 11 Echocardiography Chapter 12 Fetal Echocardiography Chapter 13 Cardiac Catheterization Chapter 14 Angiography Chapter 15 Other Imaging Techniques Chapter 16 Pediatric Exercise Testing Chapter 17 Approach to the Cyanotic Neonate Section III Structural Heart Disease Chapter 18 Incidence, Prevalence, and Inheritance of Congenital Heart Disease Chapter 19 Nomenclature and Classification Chapter 20 Nomenclature and Classification Chapter 21 Ventricular Septal Defect Chapter 22 Atrial Septal Defect Chapter 23 Patent Ductus Arteriosis Chapter 24 Atrioventricular Septal Defect Chapter 25 TGA Chapter 26 Double Outlet Ventricle Chapter 27 Corrected Transposition Chapter 28 Tetralogy of Fallot and Pulmonary Atresia with Ventricular Septal Defect Chapter 29 Total Anomalous Pulmonary Venous Connection Chapter 30 Tricuspid Atresia Chapter 31 Pulmonary Atresia Chapter 32 Ebstein Anomaly of the Tricuspid Valve Chapter 33 Univentricular Heart Chapter 34 Persistent Truncus Arteriosus Chapter 35 Aortic Stenosis Chapter 36 Pulmonary Stenosis Chapter 37 Coarctation of Aorta Chapter 38 Hypoplastic LV Chapter 39 Coronary Arterial Abnormalities and Congenital Anomalies of the Aortic Root Chapter 40 Malposition of the Heart Chapter 41 Vascular Ring/Sling Chapter 42 Fistulae Chapter 43 Cardiac Valvar Anomalies Chapter 44 Mitral Valve Prolapse Chapter 45 Cardiac Problems with Adults with CHD Section IV Miscellaneous Acquired Disease Chapter 46 Pulmonary Hypertension Chapter 47 Kawasaki Syndrome Chapter 48 Rheumatic Fever Chapter 49 Cardiomyopathies Chapter 50 Infective Endocarditis Chapter 51 Pericardial Disease Chapter 52 Hyperlipidemia in Children and Adolescents Chapter 53 Hypertension in Children and Adolescents Chapter 54 Congestive Heart Failure Chapter 55 Arrhythmias Chapter 56 Syncope Chapter 57 Sudden Death Chapter 58 Heritable Connective Tissue Disease Chapter 59 Cardiac Tumors Chapter 60 Vasculitides Chapter 61 Postoperative Problems Chapter 62 Neurological Problems in Childhood Heart Disease Chapter 63 Complications in Chronic Cyanotic Heart Disease Chapter 64 Pediatric Cardiac Transplantation Chapter 65 Drug Doses in Children