Clinical Trials in Psychiatry
Wiley-Blackwell (Hersteller)
978-0-470-72385-2 (ISBN)
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The authors' enthusiasm and grasp of clinical trial research make for a gripping and insightful read...it is one of the very best books that has been written on clinical trials." THE BRITISH JOURNAL OF PSYCHIATRY "The experience of both authors in this area gives the book a very pragmatic approach grounded in reality, with theoretical overviews invariably being followed by practical examples and applications...an invaluable companion to anyone involved in, or contemplating undertaking, clinical trials research." PSYCHOLOGICAL MEDICINE
Brian S. Everitt. Professor of Behavioural Statistics, Department of Biostatistics and Computing, Institute of Psychiatry, King's College, London, UK. Simon Wessely. Professor of Epidemiological and Liaison Psychiatry Director, King's Centre for Military Health Research, Institute of Psychiatry, King's College, London, UK; Department of Psychological Medicine, Weston Education Centre, London, UK.
Preface to the first edition. Preface to the second edition. 1. Treatments, good, bad or worthless - and how do we tell? 1.1 Treatments worthless - and worse. 1.2 A brief history of treating the mentally ill. 1.3 Summary. 2. The randomized clinical trial. 2.1 Introduction. 2.2 The clinical trial. 2.3 Ethical issues in clinical trials. 2.4 Informed consent. 2.5 Compliance. 2.6 Summary. 3. Design issues in clinical trials. 3.1 Introduction. 3.2 Clinical trial designs. 3.3 Methods of randomization. 3.4 Methods of masking treatments. 3.5 The size of a clinical trial. 3.6 Interim analysis. 3.7 Summary. 4. Special problems of trials in psychiatry. 4.1 Introduction. 4.2 Explanatory versus pragmatic trials. 4.3 Complex interventions. 4.4 Outcome measures in psychiatry. 4.5 Summary. 5. Some statistical issues in the analysis of psychiatric trials. 5.1 Introduction. 5.2 P-values and confidence intervals. 5.3 Using baseline data. 5.4 Longitudinal data. 5.5 Missing values and dropouts in longitudinal data. 5.6 Multiple outcome measures. 5.7 Intention-to-treat. 5.8 Economic evaluation of trials. 5.9 Number needed to treat. 6. Analysing data from a psychiatric trial: an example. 6.1 Introduction. 6.2 Beating the Blues. 6.3 Analysis of the post-treatment BDI scores. 6.4 Graphical displays and summary measure analysis of longitudinal data. 6.5 Random effects models for the BtB data. 6.6 The dropout problem in the BtB data. 6.7 Summary. 7. Systematic reviews and meta-analysis. 7.1 Introduction. 7.2 Study selection. 7.3 Publication bias. 7.4 The statistics of meta-analysis. 7.5 Some examples of meta-analysis of psychiatric trials. 7.6 Summary. 8. RCTs in psychiatry: threats, challenges and the future. 8.1 Introduction. 8.2 Can randomized clinical trials in psychiatry be justified? 8.3 Are randomized clinical trials really necessary? 8.4 Conflicts of interest. 8.5 Scandals, trials and tribulations. 8.6 The future of psychiatric trials. 8.7 Defending the clinical trial. 8.8 Summary. Appendix A. Issues in the management of clinical trials- 'how to do it'. A.1 Introduction. A.2 Clinical trial protocols. A.3 Getting the costs right. A.4 Collecting and managing the data. A.5 Writing the patient information sheet. A.6 Getting informed consent. A.7 Maintaining recruitment. A.8 Useful web sites. Appendix B. Writing a trial report. B.1 Introduction. Appendix C. Useful software for clinical trials. C.1 Introduction. C.2 Data management. C.3Design. C.4 Analysis. Bibliography. Index.
Erscheint lt. Verlag | 1.4.2008 |
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Verlagsort | Hoboken |
Sprache | englisch |
Maße | 175 x 249 mm |
Gewicht | 578 g |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete |
Studium ► Querschnittsbereiche ► Epidemiologie / Med. Biometrie | |
ISBN-10 | 0-470-72385-8 / 0470723858 |
ISBN-13 | 978-0-470-72385-2 / 9780470723852 |
Zustand | Neuware |
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