Chronic Lymphocytic Leukemia

SUSAN O’BRIEN is Professor of Medicine and Clinical Consultant and Special Assistant to the Physician-in-Chief, the University of Texas MD Anderson Cancer Center, Houston, Texas, USA. She received her M.D. from the University of Medicine and Dentistry of New Jersey Medical School, Newark, New Jersey, USA. In recognition of her contributions to the medical field, Dr. O’Brien has been named on the lists of "America’s Top Physicians" and "The Best Doctors in America." She is an experienced writer of and contributor to numerous books, journals, manuals, teaching aids, and other publications, and a frequent invited speaker at conferences, seminars, and conventions. Dr. O’Brien is a member of numerous professional organizations, and she currently serves as Chair of the National Comprehensive Cancer Network’s Chronic Myelogenous Leukemia Guidelines Panel. To fund her research in leukemia, she has received grants and funding from Ortho-McNeil and Berlex, Inc., among others. JOHN G. GRIBBEN is Professor of Experimental Cancer Medicine and Director of Stem Cell Transplantation, Barts and the London School of Medicine, and Medical Director of the North East London Cancer Research Network, London, UK. He received his M.D. from the University of Glasgow, Glasgow, UK. Professor Gribben leads the newly established Centre for Experimental Cancer Medicine, which facilitates translational cancer research from "basic scientific discovery" to "novel approaches to care of patients with cancer." Dr. Gribben is a founding member of the Chronic Lymphocytic Leukemia Consortium and is also a current member or fellow of several professional organizations, including the American Society for Clinical Investigation and the Academy of Medical Sciences. Dr. Gribben is the author of more than 300 articles and chapters on the subjects of stem cell transportation for cancer treatment, tumor antigens and B cell malignancies, and leukemia and lymphoma.

1. Origin and Nature of the CLL Cell. 2. Gene Expression Profiling. 3. Molecular Pathogenesis. 4. CLL and the B Cell Receptor. 5. Epidemiology and Familial CLL. 6. Apoptosis Disregulation in CLL. 7. Differential Diagnosis, Staging, and Prognostic Factors. 8. Frontline Therapy. 9. Treatment of Relapsed Disease. 10. New Therapies. 11. Transplant in CLL. 12. Gene therapy, vaccines and immune modulation. 13. PLL. 14. CLL Specific Complications: Autoimmunity and Richter’s Syndrome. 15. Infections in CLL.