25 Years of p53 Research
Springer-Verlag New York Inc.
978-1-4020-6564-4 (ISBN)
The First Twenty-Five Years of p53 Research.- Regulation of p53 DNA Binding.- 20 Years of DNA Damage Signaling to p53.- Gatekeepers of the Guardian: p53 Regulation by Post-Translational Modification, MDM2 and MDMX.- Regulation of the p53 Response by Cellular Growth and Survival Factors.- P53, Cell Cycle Arrest and Apoptosis.- P53 Has a Direct Pro-apoptotic Action at the Mitochondria.- Manipulating the p53 Gene in the Mouse: Organismal Functions of a Prototype Tumor Suppressor.- P53, P63, and P73: Internecine Relations?.- P73, P63 and Mutant P53: Members of Protein Complexs Floating in Cancer Cells.- P53: Gatekeeper, Caretaker or Both?.- Analysis of p53 Gene Alterations in Cancer: A Critical View.- Patterns of TP53 Mutations in Human Cancer: Interplay Between Mutagenesis, DNA Repair and Selection.- Prognostic and Predictive Value of TP53 Mutations in Human Cancer.- P53 Links Tumor Development to Cancer Therapy.- Novel p53-Based Therapies: Strategies and Future Prospects.- Wild Type p53 Conformation, Structural Consequences of p53 Mutations and Mechanisms of Mutant p53 Rescue.- Mutant p53 Reactivation as a Novel Strategy for Cancer Therapy.- Novel Approaches to p53-Based Therapy: ONYX-015.- p53 as Seen by an Outsider.
Zusatzinfo | XII, 446 p. |
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Verlagsort | New York, NY |
Sprache | englisch |
Maße | 155 x 235 mm |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie |
Medizin / Pharmazie ► Studium | |
ISBN-10 | 1-4020-6564-7 / 1402065647 |
ISBN-13 | 978-1-4020-6564-4 / 9781402065644 |
Zustand | Neuware |
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