Handbook of Experimental Pharmacology / Quinolone Antibacterials

The quinolones continue to make a significant contribution in the fight against community or hospital acquired infections and add a new dimension of antibacterial therapy. This volume describes in detail the chemistry, mode of action and pharmacodynamics of the quinolones. A lot of effort has been undertaken to optimize structure-activity relationships with the aim of producing more potent drugs with an optimal therapeutic index.
TOC: Contents: History and Introduction.- The Chemistry of the Quinolones: Methods of Synthesizing the Quinolone Ring System.- Chemistry in the Periphery of the Quinolones.- Mode of Action.- The In Vitro Antibacterial Activity of Quinolones: A Review.- Pharmacokinetics of Fluoroquinolones in Experimental Animals.- Pharmacodynamics of Fluoroquinolones in Experimental Animals.- Interaction of Quinolones with Host-Parasite-Relationships.- Mechanisms of Resistance to Fluoroquinolones.- Toxicology and Safety Pharmacology of Quinolones.- Clinical Pharmacology.- Concentration-Effect Relationship of the Fluoroquinolones.- Clinical Use of Quinolones.- Future Aspects.