Ventricular Arrhythmias and Sudden Cardiac Death

Paul J. Wang, MD Cardiovascular Medicine, Department of Medicine Stanford University Medical Center Stanford, CA, USA Henry H. Hsia, MD Cardiovascular Medicine, Department of Medicine Stanford University Medical Center Stanford, CA, USA Amin Al-Ahmad, MD Cardiovascular Medicine, Department of Medicine Stanford University Medical Center Stanford, CA, USA Paul C. Zei, MD Cardiovascular Medicine, Department of Medicine Stanford University Medical Center Stanford, CA, USA

List of contributors vii

Foreword xi
Hein J. Wellens

Part 1 Mechanisms of VT

1 The role of spatial dispersion of repolarization and intramural reentry in inherited and acquired sudden cardiac death syndromes 1
Charles Antzelevitch

2 Mechanisms of ventricular tachycardia: underlying pathological and physiological abnormalities 18
Jacques MT de Bakker Harold VM van Rijen

Part 2 Etiologies and syndromes

3 Time-dependent gender differences in the clinical course of patients with the congenital long-QT syndrome 28
Ilan Goldenberg Arthur J. Moss Wojciech Zareba

4 Genetics of ventricular arrhythmias 37
Zian H. Tseng Jeffrey Olgin

5 Arrhythmogenic right ventricular dysplasia/cardiomyopathy 51
Rahul Jain Hugh Calkins

6 Risk stratification and the implantable defibrillator for the prevention of sudden death in hypertrophic cardiomyopathy 64
Barry J. Maron

Part 3 Catheter and surgical ablation

7 Mapping and ablation of ventricular tachycardia after myocardial infarction 76
William G. Stevenson Usha Tedrow

8 Mapping and ablation of ventricular tachycardia in nonischemic cardiomyopathy 89
Henry H. Hsia Pirooz S. Mofrad

9 Mapping to define scars and isthmuses: a new paradigm for guiding ventricular tachycardia ablation 101
Kyoko Soejima

10 Ablation of idiopathic ventricular tachycardias 112
Nitish Badhwar Melvin M. Scheinman

11 Ablation of ventricular fibrillation 128
Karen P. Phillips J. David Burkhardt Robert A. Schweikert Walid I. Saliba Andrea Natale

12 Ablation of ventricular tachycardia in congenital heart disease 141
George F. Van Hare

13 Role of imaging techniques in catheter ablation of ventricular tachycardia 150
Mathew D. Hutchinson David J. Callans

14 Epicardial ablation of ventricular tachycardia 164
Mauricio Scanavacca Eduardo Sosa

15 Role of catheter control systems in ablation of ventricular tachycardia 178
Marco Perez Amin Al-Ahmad

16 Current surgical techniques for ischemic ventricular tachycardia 190
Robert J. Moraca Marci S. Bailey Ralph J. Damiano Jr

Part 4 Epidemiology risk stratificationand pharmacological therapy for ventricular tachycardia and sudden death

17 Epidemiology and etiologies of sudden cardiac death 198
Keane K. Lee Amin Al-Ahmad Paul J.Wang Robert J. Myerburg

18 Non-invasive tests for risk stratification in ischemic and non-ischemic cardiomyopathy 213
J. Thomas Bigger Mark C. Haigney Robert E. Kleiger

19 Risk stratification: where we are and where do we go from here 240
Jeffrey J. Goldberger

20 Pharmacological management of ventricular arrhythmias 247
Kevin J. Makati Munther Homoud Mark S. Link Jonathan Weinstock N.A. Mark Estes III

Part 5 Ventricular fibrillation and defibrillation

21 The mechanisms of ventricular fibrillation 267
Lan S. Chen Peng-Sheng Chen Moshe S. Swissa

22 Mechanisms of defibrillation 277
Derek J. Dosdall Jian Huang Raymond E. Ideker

23 Automatic external defibrillation and public access defibrillator response 289
Paul J. Wang Amin Al-Ahmad Robert J. Myerburg

24 Advances in cardiopulmonary rescuscitation 298
Anurag Gupta Amin Al-Ahmad

25 Advances in implantable defibrillator therapy and technologies 312
Paul J. Wang Amin Al-Ahmad Henry H. Hsia Paul C. Zei

26 ICD lead extraction: when why and how? 327
Bruce L. Wilkoff Oussama Wazni

Index 335