Image-Guided Radiation Therapy of Prostate Cancer

RICHARD K. VALICENTI is Clinical Director and Professor, Department of Radiation Oncology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania; and Staff Radiation Oncologist of Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania. Dr. Valicenti received his M.A. in physics from Columbia University, New York, New York, and his M.D. from Hahnemann University School of Medicine, Philadelphia, Pennsylvania. Dr. Valicenti completed residency and fellowship training at Washington University School of Medicine. He is also a principle investigator on Department of Defense and National Cancer Institute clinical trials. At Jefferson, he is the Lead Physician of the Image-guided Radiation Therapy Program for prostate cancer and has published extensively on the use of combined modality therapy. ADAM P. DICKER is Professor, Jefferson Medical College, Department of Radiation Oncology; Director, Division of Experimental Radiation Oncology; and Lead Physician, Prostate Brachytherapy Program, Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania. Dr. Dicker received his Ph.D. from Cornell University Graduate School of Medical Sciences, Sloan-Kettering Division, Molecular Pharmacology and Therapeutics, New York, New York, and his M.D. from the Cornell University Medical College, New York, New York. He has served as Chair of the Radiation Therapy Oncology Group (RTOG) Translational Research Program since 2006. Dr. Dicker, Dr. Valicenti and colleagues have previously published Basic and Advanced Techniques in Prostate Brachytherapy also with Informa Healthcare. DAVID A. JAFFRAY is Head of Radiation Physics and a Senior Scientist within the Ontario Cancer Institute at Princess Margaret Hospital, Toronto, Ontario; and holds the Fidani Chair in Radiation Physics at the University of Toronto, Ontario. Dr. Jaffray received his Ph.D. in the Department of Medical Biophysics at the University of Western Ontario, London, Ontario. Dr. Jaffray has over 80 peer-reviewed publications in the field and holds numerous peer-reviewed and industry sponsored research grants. His current research interests focus on the development of novel approaches of directing and applying radiation therapy and advancing the standard of radiation therapy delivery.

Overview and treatment guidelines for image-guided treatment in prostate cancer management. Imaging modalities. Modeling potential benefits from IGRT. Pelvic and prostate anatomy, implications for IGRT. Image-guided treatment planning and localization modalities. Image-guidance: the urologist perspective. IGRT in prostate cancer: focus on fiducials. IGRT in prostate cancer: focus on BAT and ultrasound. IGRT in prostate cancer: focus on adaptive therapy. IGRT in postoperative RT for prostate cancer. The use of image-guidance in prostate brachytherapy. IGRT in prostate cancer: targeting pelvic lymph nodes. Fractionation issues with IGRT for clinically localized prostate cancer. Image-guided proton beam radiotherapy. Future developments: On-line dosimetric verification and cone-beam RT planning and verification.