Antithrombotic Drug Therapy in Cardiovascular Disease

Basic Principles.- Platelets in Arterial Thrombosis.- The Role of Coagulation in Arterial and Venous Thrombosis.- The Link Between Inflammation and Thrombosis.- The Genetics of Thrombosis.- Antithrombotic Therapy for Stable Coronary Atherosclerotic Disease.- Aspirin in Primary and Secondary Prevention of Cardiovascular Disease.- Thienopyridines in Stable Coronary Disease.- Antithrombotic Therapy for NSTE ACS.- Antiplatelet Therapies in Unstable Angina and Non-ST Segment Elevation Myocardial Infarction.- Unfractionated Heparin and Enoxaparin for the Management of Non-ST-Segment Elevation Acute Coronary Syndromes.- Direct Thrombin Inhibitors in Acute Coronary Syndromes.- Synthetic Factor Xa Inhibition in Acute Coronary Syndromes.- Antithrombotic Therapy for STEMI.- Antiplatelet Therapies: Aspirin, Clopidogrel and Thienopyridines, and Glycoprotein IIb/IIIa Inhibitors for the Management of ST-Segment Elevation Myocardial Infarction.- Antithrombin Therapy for Acute ST-Segment Elevation Myocardial Infarction.- Fibrinolysis and Facilitated PCI.- Antithrombotic Therapy in Interventional Cardiology.- Antithrombotic Therapy in Percutaneous Coronary Intervention.- Antithrombotic Therapy in Carotid and Peripheral Intervention.- Monitoring of Antithrombotic Therapies in Interventional Cardiology.- Antithrombotic Therapy in Venous Thromboembolism.- Venous Thromboembolism.- Fibrinolysis for Pulmonary Embolism.- Duration of Anticoagulant Therapy After Venous Thromboembolism.- Clinical Consideration.- Antithrombotic Therapy for Atrial Fibrillation and Cardioversion.- Antithrombotic Therapy for Valvular Heart Disease.- Antithrombotic Therapy in Heart Failure and Cardiomyopathy.- Heparin-Induced Thrombocytopenia.- Resistance to Antiplatelet Drugs.

From the reviews:

Despite substantial therapeutic progress, considerable morbidity and mortality remains associated with thrombotic events but rapid expansion of the available armamentarium to combat pathologic thrombosis is nicely summarized in this excellent new book which becomes a valuable guide to improved therapy. The experts from the field, selected by its editors, survey individual and various combinations of the available antithrombotic regimens including fibrinolytic agents, antiplatelet therapies (aspirin, thieneopyridines, glycoprotein IIb/IIIa inhibitors), and anticogulant therapies (unfractionated heparin, low-molecular-weight heparins, direct thrombin inhibitors, and synthetic factor X inhibitors). The treatments discussed are up-to-date methods for management of common cardiovascular thrombotic problems designed for appropriate clinical use. Numerous illustrations, tables and figures throughout the book become particularly helpful for the reader.

There are seven major divisions covered by twenty four chapters; most of which are multi-authored and include: Basic Principles, Antithrombotic Therapy for Stable Coronary Atherosclerotic Disease, Antithrombotic Therapy for NSTE ACS, Antithrombotic Therapy for STEMI. Antithrombotic Therapy in Interventional Cardiology, Antithrombotic Therapy in Venous Thromboembolism, and Clinical Considerations.

The coagulationist should find this text to be a valuable addition to his/her office reference book shelf.

William H Wehrmacher MD FACP FACC
Harry L Messmore MD FACP

from Comprehensive Therapy - 2010

“The chapter authors of this multiauthored book on antithrombotic drug therapy in cardiovascular disease are national and international thought leaders in their respective fields. … The intended audience includes medical students, allied health professionals, physicians in training, and cardiovascular physicians. … This will be a valuable resource for healthcare providers in the field of cardiovasculardisease management. The authors have met their objective of providing a high quality, evidence-based review of this field.” (Timir Paul, Doody’s Review Service, March, 2009)