Molecular Pathology of Lung Diseases

Basic Concepts of Molecular Pathology.- Genes, Gene Products, and Transcription Factors.- Receptors, Signaling Pathways, Cell Cycle, and DNA Damage Repair.- Cell Adhesion Molecules.- Apoptosis and Cell Death: Relevance to Lung.- Roles of Mutation and Epimutation in the Development of Lung Disease.- Techniques and Experimental Systems in Molecular Pathology.- Bioinformatics and Omics.- General Approach to Molecular Pathology.- Applications of Molecular Tests in Anatomic Pathology.- Polymerase Chain Reaction and Reverse Transcription&##x2014;Polymerase Chain Reaction.- Array Comparative Genomic Hybridization in Pathology.- Loss of Heterozygosity in Lung Diseases.- In Situ Hybridization: Principles and Applications for Pulmonary Medicine.- Proteomics.- Animal Models of Lung Disease.- Tissue Culture Models.- Molecular Pathology of Pulmonary and Pleural Neoplasms: General Principles.- Molecular Oncogenesis of Lung Cancer.- Genetic Susceptibility.- Prognostic Markers.- Pulmonary Angiogenesis in Neoplastic and Nonneoplastic Disorders.- Lung Cancer Stem Cells.- Gene Therapy Approaches for Lung Cancer.- Response to Conventional Therapy and Targeted Molecular Therapy.- Environmental Agents in Lung and Pleural Neoplasms.- Viral Oncogenesis.- Molecular Pathology of Pulmonary and Pleural Neoplasms: Specific Histologic Types.- Adenocarcinoma and Its Precursor Lesions.- Molecular Pathology of Squamous Cell Carcinoma and Its Precursors.- Molecular Pathology of Large Cell Carcinoma and Its Precursors.- Small Cell Carcinoma.- Neuroendocrine Carcinomas and Precursors.- Pulmonary Lymphomas.- Posttransplantation Lymphoproliferative Disorder.- Unusual Benign and Malignant Neoplasms of Lung: Molecular Pathology.- Primary Versus Metastatic Cancer: Gene Expression Profiling.- Diffuse MalignantMesothelioma: Genetic Pathways and Mechanisms of Oncogenesis of Asbestos and Other Agents That Cause Mesotheliomas.- Molecular Pathology of Pediatric Tumors of the Lung.- Molecular Pathology of Pulmonary Infections.- Basis of Susceptibility to Lung Infection.- Molecular Pathology of Viral Respiratory Diseases.- Molecular Pathology of Rickettsial Lung Infections.- Bacteria.- Immunopathology of Tuberculosis.- Molecular Pathology of Fungal Lung Infection.- Parasites.- Molecular Pathology of Other Nonneoplastic Pulmonary Diseases: General Principles.- Inflammation.- Oxidants and Antioxidants.- Epithelial Repair and Regeneration.- Fibrogenesis.- Stem Cells in Nonneoplastic Lung Disorders.- Gene Therapy in Nonneoplastic Lung Disease.- Molecular Pathology of Other Nonneoplastic Pulmonary Diseases: Specific Entities.- Smoking-Related Lung Diseases.- Heritable ?1-Antitrypsin Deficiency.- Asthma.- Cystic Fibrosis.- Pulmonary Organogenesis and Developmental Abnormalities.- Genetic Abnormalities of Surfactant Metabolism.- Usual Interstitial Pneumonia.- Sarcoidosis: Are There Sarcoidosis Genes?.- Histiocytic Diseases of the Lung.- Pulmonary Arterial Hypertension.- Immunopathology of Pulmonary Vasculitides.- Asbestosis and Silicosis.