Vascular Complications in Human Disease

Professor Dame Carol Black DBE, PRCP, President of the Royal College of Physicians, Professor and Head Of Academic and Clinical Department of Rheumatology, The Royal Free Hospital and University College London, UK. Professor David Abraham PhD, Head of Research, Academic and Clinical Department of Rheumatology, The Royal Free Hospital and University College London, UK. Dr Gerry Coghlan MD, Consultant Cardiologist, Director of the Pulmonary Hypertension Unit, The Royal Free Hospital, London, UK. Dr Michael Dashwood, PhD, Senior Lecturer in Biochemistry, University College London, UK. Dr Christopher Denton, PhD, Senior Lecturer and Consultant Rheumatologist, The Royal Free Hospital and University College London, UK. Dr Clive Handler MD, Honorary Consultant, Pulmonary Hypertension Unit, The Royal Free Hospital, London, UK. All the authors are internationally respected and leading clinical and basic scientists and clinicians.

Treatments for Pulmonary Vascular Disease.- Therapy for Pulmonary Vascular Disease: Past, Present, and Future.- Nitric Oxide Axis in Cardiopulmonary Disease.- Endothelin Signaling in the Cardiomyocyte.- TGF-?/BMP Signaling in Pulmonary Vascular Disease.- Model Systems.- Endothelin System in Chronic Kidney Disease.- Endothelial Activation in Inflammation: Lessons Learned from E-Selectin.- Pathogenic Mediators of Vessel Sclerosis: Regulation of Vascular Smooth Muscle Cell Proliferation by Growth Factors, the Extracellular Matrix, and the Endothelium.- Control of Interstitial Fluid Homeostasis: Roles of Growth Factors and Integrins.- Vascular Complications.- Vascular Complications of Systemic Sclerosis: A Molecular Perspective.- Therapeutic Options for Preventing Transplant-Related Progressive Renal and Vascular Injury.- Surgical Approaches.- Current State of Medical Therapies for Peripheral Vascular Disease.- Advantages of Harvesting the Saphenous Vein for Coronary Artery Bypass Surgery Using the “No-Touch” Technique.- Toward the Prevention of Vein Graft Failure.- Genetics, Gene Therapy, and Tissue Engineering.- Statins and Cholesterol: How Low Can You Go?.- Endothelin-1-Promoting Actions in the Growth and Angiogenesis of Solid Cancers.- Gene Therapy for Apolipoprotein A-I and HDL—The Ultimate Treatment for Atherosclerosis.- ETS Family of Transcription Factors and the Vascular System.- Aortic Valve: From Function to Tissue Engineering.