Salivary Diagnostics

David Wong is Associate Dean of Research, Professor of Oral Biology, Oral Biology & Medicine, and Director of Dental Research Institute at UCLA. Dr. Wong is a dentist-scientist focusing his research on the molecular determinants (genomic and proteomic) of head and neck cancer. His research has been continuously funded by the NIDCR and NCI for the past 18 years. He has achieved two 4-year award U01 awards from the NIDCR for the creation of the UCLA Collaborative Oral Fluid Diagnostic Research Center and the Human Salivary Proteome project.

Contributors viii

Foreword xv

Preface xvii

Acknowledgment xviii

I Background and Foundation

1 Salivary Gland Development and Regeneration 3
Sarah M. Knox and Matthew P. Hoffman

2 Salivary Gland Physiology Relevant to Diagnostics 14
Victor G. Romanenko and James E. Melvin

3 Saliva: Properties and Functions 27
Arie van Nieuw Amerongen, Enno C.I. Veerman, and Arjan Vissink

4 Saliva Collectors 37
Arjan Vissink, Andy Wolff, and Enno C.I. Veerman

5 Salivary Secretion in Health and Disease 60
Michael D. Turner and Jonathan A. Ship

6 Processing and Storage of Saliva Samples 69
Enno C.I. Veerman, Arjan Vissink, David T. Wong, and Arie van Nieuw Amerongen

II Saliva Diagnostics

7 Historical Perspectives and Present 79
Frank G. Oppenheim

8 Diagnostics Other Than Blood 94
Sudhir Srivastava and Karl Krueger

9 Perceptions of Saliva: Relevance to Clinical Diagnostics 104
Sreenivas Koka and David T. Wong

10 Saliva-Based Diagnostic Technologies: Highlights of the NIDCR's Program 111
Eleni Kousvelari, John T. McDevitt, Daniel Malamud, David T. Wong, and David R. Walt

11 Human Salivary Proteomics 122
Shen Hu, Markus Hardt, Susan J. Fisher, David T. Wong, John R. Yates, James E. Melvin, and Joseph A. Loo

12 Genomic Targets in Saliva 129
Bernhard G. Zimmermann, Zhanzhi Hu, and David T. Wong

13 Point-of-Care Diagnostics for Infectious diseases 136
Paul L.A.M. Corstjens, Daniel Malamud

14 Dental Caries Risk Assessment 150
Paul C. Denny and Patricia A. Denny

15 Periodontal Disease 156
Christoph A. Ramseier, Thiago Morelli, Janet S. Kinney, Meghan Dubois, Lindsay Rayburn, and William Giannobile

16 Role of Saliva in Detection of Substance Abuse 169
Uttam Garg and Lance Presley

17 Head and Neck Cancer 180
Joseph A. Califano and Suhail K. Mithani

18 Sjogren's Syndrome 189
Philip C. Fox

19 Salivary Gland Dysfunction Associated with Systemic Disease 198
Nelson L. Rhodus

20 Progression and Treatment Evaluation in Diseases Affecting Salivary Glands 214
Jiska M. Meijer, Cees G.M. Kallenberg, and Arjan Vissink

21 The Uses of Saliva in Forensic Genetics 226
Jack Ballantyne and Jane Juusola

22 SPKB—Salivary Proteome Knowledge Base: A Platform for Collaborative Proteomics Research 233
Weihong Yan, Weixia Yu, Shawn Than, Renli Qiao, D. Stott Parker, Joseph A. Loo, and David T. Wong

III Saliva Diagnostics—A New Industry

23 Commercialization of Oral Fluid Products and Technologies 243
R. Sam Niedbala

24 Coverage and Reimbursement for Salivary Diagnostic Tests 255
James J. Crall

25 Saliva Diagnostics in the Dentist's and Physician's Office 263
Chakwan Siew and Milton V. Marshall

26 Salivary Hormones in Research and Diagnostics 270
Douglas A. Granger, Christine K. Fortunato, Leah C. Hibel

27 Crossroads Between Saliva Diagnostics and Salivary Gland Gene Therapy 278
Bruce J. Baum, Ana P. Cotrim, Corinne M. Goldsmith, Fumi Mineshiba, Senrong Qi, Gabor Z. Racz, Yuval Samuni, Takayuki Sugito, Antonis Voutetakis, and Changyu Zheng

28 Saliva Diagnostics—A New Industry 288
Stuart R. Smith, David T. Wong, and R. Michael Buch

Index 295