Angiogenesis

Physiological & Pathological Angiogenesis: Biology of the Angiogenic Process.- History of Angiogenesis.- Angiogenesis and Vascular Remodeling in Inflammation and Cancer: Biology and Architecture of the Vasculature.- Endothelial Cell Activation.- Pericytes, the Mural Cells of the Microvascular System.- Matrix Metalloproteinases and Their Endogenous Inhibitors.- Integrins in Angiogenesis.- Angiogenesis and Regulatory Proteins.- Fibroblast Growth Factor-2 in Angiogenesis.- Vascular Permeability/Vascular Endothelial Growth Factor.- Platelet-Derived Growth Factor.- Angiopoietins and Tie Receptors.- Basement Membrane Derived Inhibitors of Angiogenesis.- Angiostatin and Endostatin: Angiogenesis Inhibitors in Blood and Stroma.- Thrombospondins: Endogenous Inhibitors of Angiogenesis.- Molecular & Cellular Mechanisms of the Angiogenic Process.- Overview of Angiogenesis During Tumor Growth.- Hypoxic Regulation of Angiogenesis by HIF-1.- Regulation of Angiogenesis by von Hippel Lindau Protein and HIF2.- Nitric Oxide in Tumor Angiogenesis.- VEGF Signal Tranduction in Angiogenesis.- Delta-like Ligand 4/Notch Pathway in Tumor Angiogenesis.- Immune Cells and Inflammatory Mediators as Regulators of Tumor Angiogenesis.- Contribution of Endothelial Progenitor Cells to the Angiogenic Process.- Tumor Angiogenesis and the Cancer Stem Cell Model.- Targeting the Tumor Microenvironment (Stroma) for Treatment of Metastasis.- Functional Assessments of Angiogenesis.- Normalization of Tumor Vasculature and Microenvironment.- Targeted Drug Delivery to the Tumor Neovasculature.- Models for Angiogenesis.- Surrogates for Clinical Development.- Imaging of Angiogenesis.- Tumor Endothelial Markers.- Clinical Translation of Angiogenesis Inhibitors.- Overview and Clinical Applications of VEGF-A.- Protein Tyrosine Kinase Inhibitors as Antiangiogenic Agents.- Therapeutic Strategies that Target the HIF System.- The Clinical Utility of Bevacizumab.- Development of Thalidomide and Its IMiD Derivatives.- TNP-470: The Resurrection of the First Synthetic Angiogenesis Inhibitor.- Clinical Development of VEGF Trap.- Recent Advances in Angiogenesis Drug Development.- Combination of Antiangiogenic Therapy with Other Anticancer Therapies.- Immunotherapy of Angiogenesis with DNA Vaccines.- Challenges of Antiangiogenic Therapy of Tumors.- Pharmacogenetics of Antiangiogenic Therapy.- Angiogenesis in Health & Disease.- Angiogenesis in the Central Nervous System.- Lymphatic Vascular System and Lymphangiogenesis.- Ocular Neovascularization.- Angiogenesis and Pathology in the Oral Cavity.- Revascularization of Wounds: The Oxygen-Hypoxia Paradox.- Journeys in Coronary Angiogenesis.- Perspectives on the Future of Angiogenesis Research.