Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response

Genomic Experimental Approaches in Oncology.- Toward the Realization of the Promise of Microarrays in Oncology.- Cell-Based Models to Identify Genetic Variants Contributing to Anticancer Drug Response.- Proteomic Analysis in Cancer Patients.- MicroRNAs and Discovery of New Targets.- Pharmacogenomics of the National Cancer Institute’s 60-Tumor Cell Panel.- Use of Single-Nucleotide Polymorphism Array for Tumor Aberrations in Gene Copy Numbers.- Pharmacogenomics of Toxicity and Response of Chemotherapy.- Concordance Between Tumor and Germline DNA.- Epidermal Growth Factor Receptor Mutations and Sensitivity to Selective Kinase Inhibitors in Human Lung Cancer.- BCR-ABL Mutations and Imatinib Resistance in Chronic Myeloid Leukemia Patients.- Role of Thymidylate Synthase Gene Variations in Colorectal Cancer Patients.- Thiopurines in the Treatment of Childhood Acute Lymphoblastic Leukemia and Genetic Variants of the Thiopurine S-Methyltransferase Gene.- Impact of Polymorphisms on the Clinical Outcomes of Monoclonal Antibody Therapy Against Hematologic Malignancies.- DNA Repair and Mitotic Checkpoint Genes as Potential Predictors of Chemotherapy Response in Non-Small-Cell Lung Cancer.- Dihydropyrimidine Dehydrogenase (Dpyd) Gene Polymorphism: Portrait of a Serial Killer.- Impact of UDP-Glucuronosyltransferase 1A Haplotypes on Irinotecan Treatment.- Microarray Profiling in Breast Cancer Patients.- Role of the Folate-Pathway and the Thymidylate Synthase Genes in Pediatric Acute Lymphoblastic Leukemia Treatment Response.- Pharmacogenomics in Clinical Drug Development in Oncology.- Pharmacogenomics in Drug Development: A Pharmaceutical Industry Perspective.- Identification of Pharmacogenomic Biomarker Classifiers in Cancer Drug Development.- Toxicogenomics Application to OncologyDrug Development.- Strategies to Identify Pharmacogenomic Biomarkers: Candidate Gene, Pathway-Based, and Genome-Wide Approaches.