Chemistry for Pharmacy Students
Wiley-Blackwell (Verlag)
978-0-470-01781-4 (ISBN)
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Various aspects of aliphatic, aromatic and heterocyclic chemistry and their pharmaceutical importance are then covered with final chapters looking at organic reactions and their applications to drug discovery and development and natural products chemistry. * accessible introduction to the key areas of chemistry required for all pharmacy degree courses* student-friendly and written at a level suitable for non-chemistry students* includes learning objectives at the beginning of each chapter* focuses on the physical properties and actions of drug molecules
Dr Satyajit Sarke BPharm (Hons) MPharm PhD FHEA. Reader in Pharmacy; Course Director, BSc (Hons) Pharmacology; Chair, MPharm Course Planning Committee; Chair, MSc Pharmaceutical Sciences Course Planning Committee; Owner and moderator: www.jiscmail.ac.uk/natprodis and www.jiscmail.ac.uk/pharmed; School of Biomedical Sciences, University of Ulster at Coleraine, Northern Ireland, UK. Dr Lutfun Nahar. School of Biomedical Sciences, University of Ulster at Coleraine, Northern Ireland, UK.
Preface ix
1 Introduction 1
1.1 Role of chemistry in modern life 1
1.2 Physical properties of drug molecules 3
2 Atomic structure and bonding 17
2.1 Atoms, elements and compounds 17
2.2 Atomic structure: orbitals and electronic configurations
18
2.3 Chemical bonding theories: formation of chemical bonds
21
2.4 Electronegativity and chemical bonding 27
2.5 Bond polarity and intermolecular forces 28
2.6 Significance of chemical bonding in drug?receptor
interactions 31
3 Stereochemistry 35
3.1 Stereochemistry: definition 36
3.2 Isomerism 36
3.3 Significance of stereoisomerism in determining drug action
and toxicity 53
3.4 Synthesis of chiral molecules 55
3.5 Separation of stereoisomers: resolution of racemic mixtures
56
3.6 Compounds with stereocentres other than carbon 57
3.7 Chiral compounds that do not have a tetrahedral atom with
four different groups 57
4 Organic functional groups 59
4.1 Organic functional groups: definition and structural
features 60
4.2 Hydrocarbons 61
4.3 Alkanes, cycloalkanes and their derivatives 61
4.4 Alkenes and their derivatives 103
4.5 Alkynes and their derivatives 108
4.6 Aromatic compounds and their derivatives 112
4.7 Heterocyclic compounds and their derivatives 143
4.8 Nucleic acids 170
4.9 Amino acids and peptides 179
4.10 Importance of functional groups in determining drug actions
and toxicity 184
4.11 Importance of functional groups in determining stability of
drugs 188
5 Organic reactions 191
5.1 Types of organic reaction 191
5.2 Radical reactions: free radical chain reactions 192
5.3 Addition reactions 197
5.4 Elimination reactions: 1,2-elimination or b-elimination
223
5.5 Substitution reactions 232
5.6 Hydrolysis 260
5.7 Oxidation?reduction reactions 264
5.8 Pericyclic reactions 278
6 Natural product chemistry 283
6.1 Introduction to natural product drug discovery process
283
6.2 Alkaloids 288
6.3 Carbohydrates 303
6.4 Glycosides 319
6.5 Terpenoids 331
6.6 Steroids 352
6.7 Phenolics 359
Index 371
| Erscheint lt. Verlag | 1.8.2007 |
|---|---|
| Verlagsort | Hoboken |
| Sprache | englisch |
| Maße | 176 x 245 mm |
| Gewicht | 680 g |
| Themenwelt | Medizin / Pharmazie ► Pflege |
| Medizin / Pharmazie ► Pharmazie ► PTA / PKA | |
| Naturwissenschaften ► Biologie ► Allgemeines / Lexika | |
| Naturwissenschaften ► Chemie | |
| ISBN-10 | 0-470-01781-3 / 0470017813 |
| ISBN-13 | 978-0-470-01781-4 / 9780470017814 |
| Zustand | Neuware |
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