Cardiovascular Regeneration and Stem Cell Therapy

Annarosa Leri, MD is a lead investigator in the Cardiovascular Research Institute at the New York Medical College where this field of investigation began. She has made major contributions to our understanding of the basic mechanisms involved in stem cell regenerative therapy for the cardiovascular system. Dr. Leri is Professor of Medicine of the Cardiovascular Research Institute of the New York Medical College in Valhalla, New York. She is co-editor and author. Piero Anversa, MD is Director of the Cardiovascular Research Institute at New York Medical College, and is the founder of the field of stem cell therapy and regenerative cardiovascular medicine. In recognition of his contributions, Dr. Anversa received the 2004 Distinguished Scientist Award of the American Heart Association. William H Frishman, MD is one of the leading cardiovascular investigators in the world, with emphasis in the area of cardiovascular therapeutics. He is author, co-author, editor and co-editor of 12 textbooks and 800 original articles and chapters. He is currently supplements editor of the American Journal of Medicine, co-editor of the Year Book of Medicine and co-editor-in-chief of the journal Cardiology in Review. Dr. Frishman is the Rosenthal Professor and Chairman of the Department of Medicine at New York Medical College in Valhalla, New York. He is co-editor and co-author.

Contributors. Preface.

Introduction.

Annarosa Leri, Piero Anversa, William Frishman.

Part I Stem Cell Biology.

1 Homing of Stem Cells and Tissue Injury.

Ayelet Dar, Orit Kollet, Tsvee Lapidot.

2 Adult Stem Cell Plasticity: Lineage potential on a Continuum.

Peter J. Quesenberry, Gerald Colvin, Mehrdad Abedi.

3 Embryonic Stem Cells and Cardiogenesis.

Timothy J. Kamp, Gary E. Lyons.

4 Mesenchymal Stem Cell-Derived Cardiomyogenic Cells.

Keiichi Fukuda, Jun Fujita, Daihiko Hakuno, Shinji Makino.

5 Bone Marrow Cells and Vascular Growth.

Takayuki Asahara.

6 Progenitor Cells and Vascular Repair.

Kaushik Mandal, Marjan Jahangiri, Qingbo Xu.

Part II Cardiac Progenitor Cells in the Adult Heart.

7 Cardiac Side Population Cells: Phenotype and Functional Significance.

Ronglih Liao, Frederic Mouquet, Otmar Pfister.

8 Phenotype and Function of c-kit Positive-Derived Amplifying Myocytes.

Rachel Wilson, Xiongwen Chen, Hajime Kubo, Remus Berretta, Steven Houser.

9 Cardiac Stem Cells and their Niches.

Annarosa Leri, Alessandro Boni, Robert Siggins, Angelo Nascimbene, Toru Hosoda.

10 Activation of the Local Regenerative System of the Heart.

Antonia Germani, Federica Limana, Maurizio C. Capogrossi.

Part III Progenitor Cells and the Diseased Heart.

11 Embryonic Stem Cells and Myocardial Regeneration.

Ahmad Y. Sheikh, Phillip C. Yang, Joseph C. Wu, Robert C. Robbins.

12 Bone Marrow-Derived Cells in Myocardial Repair and Regeneration.

Raj Kishore, Douglas W. Losordo.

13 Endothelial Progenitor Cells And The Infarcted Heart.

Stefanie Dimmeler, Masamichi Koyanagi, Carmen Urbich, Andreas M. Zeiher.

14 Cytokines and Heart Remodeling.

Issei Komuro, Hiroyuki Takano.

15 IGF-1, Muscle Progenitors and Heart Failure.

Nadia Rosenthal, Nadine Winn, Maria Paola Santini.

Part IV Cardiac Progenitor Cells and Heart Failure.

16 Cardiac Stem Cells and the Diabetic Cardiomyopathy.

Jan Kajstura, Nicole LeCapitaine, Maria Loredo, Marco Giorgio, Thomas S. Mitchell, Susanna Valentini, Francesco Rotatori, Pier Giuseppe Pelicci.

17 Stem Cells and Cardiac Aging.

Roberto Bolli, Piero Anversa.

18 Bioengineered Scaffolds: Myocytes, Endothelial Cells and Cardiac Repair.

Vincent F.M. Segers, Richard T. Lee.

19 Gene Therapy and Cellular Therapy in Cardiac Repair.

Mark A. Sussman.

20 Cardiac Stem Cells and the Failing Heart.

Piero Anversa, Konrad Urbanek, Claudia Bearzi, Antonella De Angelis, Marcello Rota.

21 Myocardial Infarction: Risks and Hope.

Marc A. Pfeffer.

Part V Future Directions.

22 Conclusions – Future Directions.

Piero Anversa, Edmund H. Sonnenblick, William Frishman.

Index