Principles and Methods of Toxicology, Fifth Edition

Buch | Hardcover

2296 Seiten

2007 | 5th New edition
Informa Healthcare (Verlag)
978-0-8493-3778-9 (ISBN)

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Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanisms. While the vastness of the field and the rapid accumulation of data may preclude the possibility of absorbing and retaining more than a fraction of the available information, a solid understanding of the underlying principles is essential.

Extensively revised and updated with four new chapters and an expanded glossary, this fifth edition of the classic text, Principles and Methods of Toxicology provides comprehensive coverage in a manageable and accessible format. New topics include 'toxicopanomics', plant and animal poisons, information resources, and non-animal testing alternatives. Emphasizing the cornerstones of toxicology-people differ, dose matters, and things change, the book begins with a review of the history of toxicology and followed by an explanation of basic toxicological principles, agents that cause toxicity, target organ toxicity, and toxicological testing methods including many of the test protocols required to meet regulatory needs worldwide. The book examines each method or procedure from the standpoint of technique and interpretation of data and discusses problems and pitfalls that may be associated with each. The addition of several new authors allow for a broader and more diverse treatment of the ever-changing and expanding field of toxicology.

Maintaining the high-quality information and organizational framework that made the previous editions so successful, Principles and Methods of Toxicology, Fifth Edition continues to be a valuable resource for the advanced practitioner as well as the new disciple of toxicology.

Principles of Toxicology
Harming and Helping Through Time: The History of Toxicology, R.W. Lane and J.F. Borzelleca

The Use of Toxicology in the Regulatory Process, B.D. Beck, E.J. Calabrese, T.M. Slayton, and R. Rudel

Metabolism: A Determinant of Toxicity, R. Kemper, J.R. Hayes, and M.S. Bogdanffy

Toxicokinetics, A.G. Renwick

Physiologically Based Pharmacokinetic and Toxicokinetic Models, K.Krishnan and M.E. Andersen

Toxicopanomics: Applications of Genomics, Proteomics, and Metabonomics in Predictive and Mechanistic Toxicology, D. Robertson, S. Beushausen, and W. Pennie

The Toxicologic Assessment of Pharmaceutical and Biotechnology Products, M.A. Dorato, C. McMillian, and M.J. Vodicnik

Statistics for Toxicologists, S. C. Gad

Quantitative Extrapolations in Toxicology, J.V. Rodricks, D.M. Gaylor, and D. Turnbull

The Practice of Exposure Assessment, D.J. Paustenbach and A.K. Madl

Epidemiology for Toxicologists, R.R. Cook

Principles of Pathology for Toxicology Studies, S.R. Frame and P.C. Mann

The Information Infrastructure of Toxicology, P. Wexler, P. Hakkinen, P. Nance, A. Parker, and J. Patterson

Agents
Foodborne Toxicants, C.S. Reddy and A. Wallace Hayes

Solvents and Industrial Hygiene, D.L. Dahlstrom and M. Buckalew

Crop Protection Chemicals: Mechanism of Action and Hazard Profiles, C.B. Breckenridge and J.T. Stevens

Metals, J.C. Merrill, J.J.P. Morton, and S.D. Soileau

Ionizing Radiation, L.G. Cockerham, T.L. Walden, Jr., C.E. Dallas, G.A. Mickley, Jr., and M.A. Landauer

Plant and Animal Toxins, F.W. Oehme and D.E. Keyler

Methods
The Use of Laboratory Animals in Toxicology Research, W.J. White, C.T. Hawk, and M.A. Vasbinder

Validation and Regulatory Acceptance of New, Revised, and Alternative Toxicological Methods, W.S. Stokes and L.M. Schechtman

Acute Toxicity and Eye Irritancy, M.E. Blazka and A. Wallace Hayes

Genetic Toxicology, D.J. Brusick, W.R. Fields, B.C. Myhr, and D.J. Doolittle

Short-Term, Subchronic, and Chronic Toxicology Studies, N.H. Wilson, J.F. Hardisty, and J.R. Hayes

Principles of Testing for Carcinogenic Activity, G.M. Williams, M.J. Iatropoulos, and H.G. Enzmann

Principles of Clinical Pathology for Toxicology Studies, R.L. Hall and N.E. Everds

Dermatotoxicology, B.B. Hayes, E. Patrick, and H. Maibach

Inhalation Toxicology, R. Valentine and G.L. Kennedy

Detection and Evaluation of Chemically Induced Liver Injury, G.L. Plaa and M.Charbonneau

Principles and Methods for Renal Toxicology, L.H. Lash

Gastrointestinal Toxicology, R.W. Kapp, Jr.

Principles and Methods of Cardiac Toxicology, Y.J. Kang

Assessment of Male Reproductive Toxicity, S.D. Perreault, G.R. Klinefelter, and E. Clegg

Test Methods for Assessing Female Reproductive and Developmental Toxicology, M.S. Christian

Hormone Assays and Endocrine Function, R.W. Kapp, Jr., and J.A. Thomas

Immunotoxicology: Effects of and Response to Drugs and Chemicals, J.H. Dean, R.V. House, and M.I. Luster

Assessment of Behavioral Toxicity, D.A. Cory-Slechta and B. Weiss

Application of Isolated Organ Perfusion Techniques in Toxicology, H.M. Mehendale

Organelles as Tools in Toxicology, B.A. Fowler, M.L. Haasch, K.S. Squibb, and A. Wallace Hayes

Analysis and Characterization of Enzymes and Nucleic Acids, F.P. Guengerich and C.J. Bartleson

Modern Instrumental Methods for Studying Mechanisms of Toxicology, P.A. Crooks, D.R. Worthen, G.D. Byrd, J.D. deBethizy, and W.S. Caldwell

Methods in Environmental Toxicology, M.A. Lewis, A. Fairbrother, and R.E. Menzer

Glossary

Index

Erscheint lt. Verlag	25.9.2007
Zusatzinfo	45 Halftones, black and white; 473 Tables, black and white; 748 Illustrations, black and white
Verlagsort	New York
Sprache	englisch
Maße	216 x 279 mm
Gewicht	3311 g
Themenwelt	Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
ISBN-10	0-8493-3778-X / 084933778X
ISBN-13	978-0-8493-3778-9 / 9780849337789
Zustand	Neuware