The Human Frontal Lobes, Second Edition

Bruce L. Miller, MD, is Professor of Neurology at the University of California at San Francisco (UCSF), where he holds the A.W. & Mary Margaret Clausen Distinguished Chair. He is also the clinical director of the aging and dementia program at UCSF, where he heads the State of California Research and Clinical Center and a new National Alzheimer’s Disease Research Center. For nearly two decades, Dr. Miller has been the scientific director of the John Douglas French Foundation for Alzheimer’s Disease. He has been listed in The Best Doctors in America since 1996. Dr. Miller directs a National Institutes of Health-funded program on frontotemporal dementia (FTD) called “FTD: Genes, Images, and Emotions.” He has published more than 250 articles. Jeffrey L. Cummings, MD, is Director of the Alzheimer’s Disease Research Center and the Deane F. Johnson Center for Neurotherapeutics at the University of California at Los Angeles (UCLA). He is the Augustus S. Rose Professor of Neurology and Professor of Psychiatry and Biobehavioral Sciences in the David Geffen School of Medicine at UCLA. Dr. Cummings is past president of the American Neuropsychiatric Society and the Behavioral Neurology Society. He is the recipient of several prestigious awards, including the Henderson Lectureship of the American Neurological Society. Dr. Cummings has lectured, pursued research, and published on the topics of neuropsychiatry, behavioral neurology, neurotherapeutics, and drug development. He has contributed to the understanding of the role of the frontal-subcortical circuits in the behavior of normal individuals and of persons with brain disorders, and is the author of the Neuropsychiatric Inventory, a tool used to assess behavioral changes in patients with neurological diseases.

I. Overview of the Frontal Lobes
1. The Human Frontal Lobes: An Introduction, Bruce L. Miller
2. Conceptual and Clinical Aspects, Jeffrey L. Cummings and Bruce L. Miller
II. Anatomy
3. Frontal-Subcortical Circuits, Tiffany W. Chow and Jeffrey L. Cummings
4. The Dorsolateral and Cingulate Cortex, Daniel I. Kaufer
5. The Orbitofrontal Cortex and the Insula, Jennifer Ogar and Maria Luisa Gorno-Tempini
6. Structural and Functional Asymmetries of the Human Frontal Lobes, Daniel H. Geschwind and Marco Iacoboni
7. Gross Morphology and Architectonics, Danielle Andrea Carlin
8. Evolution of the Frontal Lobes, Harry J. Jerison
III. Neurochemistry
9. Serotonin and the Frontal Lobes, Philippe H. Robert, Michel Benoit, and Hervé Caci
10. Oiling the Gears of the Mind: Roles for Acetylcholine in the Modulation of Attention, Serena Amici and Adam L. Boxer
11. The Mesocortical Dopaminergic System, Antonello Bonci and Susan Jones
IV. Functional and Structural Imaging Approaches
12. Structural Imaging of the Frontal Lobes, Howard Rosen and David Dean
13. Unifying Prefrontal Cortex Function: Executive Control, Neural Networks, and Top-Down Modulation, Adam Gazzaley and Mark D'Esposito
14. Insight into Frontal Lobe Function from Functional Neuroimaging Studies of Episodic Memory, W. Dale Stevens and Cheryl L. Grady
15. The Frontal Lobes and Autobiographical Memory, Margaret C. McKinnon, Eva Svoboda, and Brian Levine
16. Planning and the Brain, Jordan Grafman
17. Principles of Motor Control by the Frontal Lobes as Revealed by the Study of Voluntary Eye Movements, Adam L. Boxer
V. Neuropsychological Functions
18. Bedside Frontal Lobe Testing, Joel H. Kramer and Lovingly Quitania
19. New Approaches to Prefrontal Lobe Testing, Donald T. Stuss
20. Language and Frontal Cortex, Argye E. Hillis
21. Self-Representation and the Frontal Lobes, William W. Seeley and Virginia E. Sturm
22. Frontal Dysfunction and Capacity to Consent to Treatment or Research: Conceptual Considerations and Empirical Evidence, LauraB. Dunn, Barton W. Palmer, and Jason H. T. Karlawish
23. Social Cognition in Frontal Injury, Katherine P. Rankin
VI. Neurological Diseases
A. Frontotemporal Dementia and Related Disorders
24. Clinical Aspects of Frontotemporal Dementia, Pei-Ning Wang and Bruce L. Miller
25. Genetics and Neuropathology of Frontotemporal Dementia, Nigel J. Cairns, Virginia M.-Y. Lee, and John Q. Trojanowski
26. Imaging in Frontotemporal Dementia, Murray Grossman
27. Progressive Supranuclear Palsy, Corticobasal Degeneration, and the Frontal Cortex, Irene van Balken and Irene Litvan
28. Frontal Variant of Alzheimer's Disease, Julene K. Johnson, Arne Brun, and Elizabeth Head
B. Other Neurological Disorders
29. Vascular Disease of the Frontal Lobes, Ae Young Lee and Helena Chui
30. Parkinson's Disease with and without Dementia and Lewy Body Dementia, Bruno Dubois, Bernard Pillon, and Ian G. McKeith
31. Neurosurgical Intervention for Psychiatric Illness: Past, Present, and Future, Anthony P. Weiss, Scott L. Rauch, and Bruce H. Price
32. Infectious, Inflammatory, and Demyelinating Disorders, Douglas W. Scharre
33. Traumatic Brain Injury, Judith Aharon-Peretz and Rachel Tomer
34. Adult-Onset Genetic Disorders Involving the Frontal Lobes, Michael D. Geschwind, Grace Yoon, and Jill Goldman
35. Frontal Lobe Development in Childhood, Carole Samango-Sprouse
VII. Psychiatric Diseases
36. Frontal Lobe Functioning in Schizophrenia: Evidence from Neuropsychology, Cognitive Neuroscience, and Psychophysiology, Susan A. Legendre Ropacki and William Perry
37. Bipolar Disorder and the Frontal Lobes, Mary G. DeMay, Danijela Pavlic, and Bruce L. Miller
38. Obsessive-Compulsive Disorder and the Frontal Lobes, Denys Fontaine, Vianney Mattei, and Philippe H. Robert
39. Depression and the Frontal Lobes, Ira M. Lesser and Julia A. Chung