Thyroid Hormone MetabolismMolecular Biology and Alternate Pathways
Crc Press Inc (Verlag)
978-0-8493-4774-0 (ISBN)
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This book gathers some of the most talented and well-informed experts in the field, who not only summarize the recent breakthroughs and new findings, but also shed light on future research. Special emphasis is placed on the exciting new understanding of the molecular structure of one of the major enzymes (type 1 iodothyronine deiodinase) involved in the activation of the thyroid hormone. This breakthrough culminates the major effort in this field around the world. As a result, we can study the regulation of thyroid hormone activation mechanism at the molecular level. Two other important deiodinase enzymes (types II and III) are also reviewed.
Alternate pathways of thyroid hormone metabolism represent another major advance. These pathways are associated with a variety of physiological and disease states, including fasting, glucocorticoid excess, fetal development, and inflammatory and non-thyroidal illnesses. The understanding of these pathways assists us to better understand the physiological and biological basis of the disease process and thus to improve clinical management of patients with thyroidal and non-thyroidal illnesses.
Foreword, G.N. Burrow.
Preface.
Molecular Structure and Biochemical Characterization of Type I Iodothyronine Deiodinase, M.J. Berry and P.R. Larsen.
Hormonal Regulation on Type II Iodothyronine Deiodinase in the Brain, J.L. Leonard and M. Safran.
Biochemical Study of Type III Iodothyronine Deiodinase, D.L. St. Germain.
The Effect of Selenium Deficiency on Thyroid Hormone Economy, L.E. Braverman.
An Integrated Assessment of Prereceptor Regulation of Thyroid Hormone Metabolism, J.T. Nicoloff and J.S. LoPresti.
Sulfation and Glucuronidation Pathways of Thyroid Hormone Metabolism, T.J. Visser.
The Role of Sulfation and Desulfation in the Thyroid Hormone Metabolism, I.J. Chopra, F. Santini, S.-Y. Wu, and R.E. Hurd.
Bioactivities of Conjugated Iodothyronines, S.W. Spaulding.
Biochemical Characterization of Triiodothyronine Sulfotransferase (T3-ST) , R.J. Anderson.
Modification on the Side Chain of Thyroid Hormones, C.A. Siegrist-Kaiser and A.G. Burger.
Ether-Link Cleavage of Iodothyronines, W.L. Green.
Alternate Pathways of Thyroid Hormone Metabolism in Developing Mammals, D.H. Polk, D.A. Fisher, and S.-Y. Wu.
Index.
Erscheint lt. Verlag | 13.7.1994 |
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Zusatzinfo | 2 Halftones, black and white |
Verlagsort | Bosa Roca |
Sprache | englisch |
Maße | 156 x 235 mm |
Gewicht | 540 g |
Einbandart | Paperback |
Themenwelt | Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie |
Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie | |
ISBN-10 | 0-8493-4774-2 / 0849347742 |
ISBN-13 | 978-0-8493-4774-0 / 9780849347740 |
Zustand | Neuware |
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