Thrombosis and Its Management

Part 1 Aetiology: how to measure the relevant effect of anticoagulant treatment on the coagulability of plasma; the molecular genetics of thrombosis; laboratory investigation of pre-thrombotic states; management of venous thromboembolism in pregnancy and puerperium; the fibrinolytic system and thrombosis. Part 2 Risk factors: fibrinogen and factor VII as risk factors for arterial thrombosis; low-intensity oral anticoagulation; lupus anticoagulants and thrombosis; thrombophilia - diagnosis and management; thrombosis in the newborn and infants; the role of von Willebrand factor in thrombosis. Part 3 Management: dignostic management of deep leg-vein thrombosis - evolution over the years 1951-1992; prevention and treatment of venous thromboembolism; antithrombotic therapy following heart valve replacement; an insight into the pharmacology of low-molecular-weight heparins; oral anticoagulants and haparin - standardization of laboratory monitoring. Part 4 Therapeutic approaches: antiplatelet drugs in the prevention of arterial thrombosis; thrombolytic therapy and myocardial infarction; oral anticoagulants in myocardial infarction 1992.