Acute Promyelitic Leukemia -

Acute Promyelitic Leukemia

Molecular Genetics, Mouse Models and Targeted Therapy
Buch | Hardcover
VIII, 274 Seiten
2006 | 2007
Springer Berlin (Verlag)
978-3-540-34592-3 (ISBN)
213,99 inkl. MwSt
Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the paradigm of translational research that began with the discovery of a recurrent chromosomal translocation, followed by the identification of the genes and proteins involved, finding their molecular functions in transcriptional control, establishing mouse models and culminating in the development  of targeted therapy.

APL as a Paradigm in Biomedical Research: A Journey Toward the Cure.- Mouse Models of Acute Promyelocytic Leukemia.- The PLZF Gene of t(11;17)-Associated APL.- SUMO, the Three Rs and Cancer.- Emerging Role for MicroRNAs in Acute Promyelocytic Leukemia.- The Theory of APL Revisited.- Treatment of Acute Promyelocytic Leukemia by Retinoids.- Arsenic Trioxide and Acute Promyelocytic Leukemia: Clinical and Biological.- Front Line Clinical Trials and Minimal Residual Disease Monitoring in Acute Promyelocytic Leukemia.- Histone Deacetylase Inhibitors in APL and Beyond.- Monoclonal Antibody Therapy of APL.- Targeting APL Fusion Proteins by Peptide Interference.- The Design of Selective and Non-selective Combination Therapy for Acute Promyelocytic Leukemia.

Erscheint lt. Verlag 13.12.2006
Reihe/Serie Current Topics in Microbiology and Immunology
Zusatzinfo VIII, 274 p. 16 illus., 9 illus. in color.
Verlagsort Berlin
Sprache englisch
Maße 155 x 235 mm
Gewicht 649 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Medizin / Pharmazie Studium
Schlagworte Aberrant transcription factor • All-trans retinoic acid (ATRA) • Arsenic trioxide • Chromosom • Chromosomal translocation • clinical trial • genes • Genetics • HLA-DR expression • leukemia • microRNA • molecular genetics • Peptides • Promyelocytic leukemia zinc finger (PLZF) • Protein • proteins • Retinoic acid receptor alpha (RARA) • Small ubiquitin-like modifier (SUMO) • targeted therapy • transcription • Translation
ISBN-10 3-540-34592-2 / 3540345922
ISBN-13 978-3-540-34592-3 / 9783540345923
Zustand Neuware
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