Ethnopharmacology of Medicinal Plants

Asia and the Pacific
Buch | Hardcover
228 Seiten
2006
Humana Press Inc. (Verlag)
978-1-58829-748-8 (ISBN)

Lese- und Medienproben

Ethnopharmacology of Medicinal Plants - Christophe Wiart
213,99 inkl. MwSt
Talks about the pharmacological potentials of one of the most exciting source of potential drugs: the medicinal plants of the Pacific Rim. This book emphasizes the fundamental importance of the precise observation of the use of each medicinal plant combined with pharmacological experiment and its botanical classification.
In 1860, Oliver Wendell Holmes pointedly expressed himself to the Massachusetts Medical Society: “I firmly believe that if the whole Material Medica, as now used, could be sunk to the bottom of the sea, it would be all the better for mankind, and all the worst for the fishes.” Should one think the same about the current approach in drug discovery from plants? Probably yes. Despite the spending of billions of US dollars, and three decades of efforts, high-throughput screenings have only allowed the discovery of a couple of drugs. One could have reasonably expected the discovery of an arsenal of drugs from the millions of plant extracts randomly tested, but “hits” can be inactive in vitro or too toxic, some molecules need to be metabolized first to be active, and false-positive and false-negative results are common. The bitter truth is that the robotic approach in discovering drugs from plants has proven, to date, its inability to excavate the hundreds of molecules that will contribute to the health progress of Man. However, one can reasonably see that the last patches of primary rainforest on earth hold still hundreds of spectacularly active drugs that await discovery.

1. Anti-Inflammatory Plants. 1.1. General Concept. 1.2. Inhibitors of Phospholipase A2. 1.3. Inhibitors of Cyclooxygenase. 1.4. Inhibitors of Lipoxygenases. 1.5. Inhibitors of Elastase. 1.6. Inhibitors of Nitric Oxide Synthetase. 1.7. Conclusion and Future Prospects. 1.8. References. 2. Plant Affecting the Central Nervous System. 2.1. General Concept. 2.2. Plants Affecting the Serotoninergic Neurotransmission. 2.3. Plants Affecting the GABAergic Neurotransmission. 2.4. Plants Interfering with the Glycinergic System. 2.5. Plants Affecting the Dopaminergic Neurotransmission. 2.6. Conclusion and Future Prospect. 2.7. References. 3. Plants for Chemotherapy of Neoplastic Diseases. 3.1. General Concept. 3.2. Topoisomerase Inhibitors. 3.3. Apoptosis. 3.4. Summary and Future Prospects. 3.5. References.

Zusatzinfo 322 Illustrations, black and white; XII, 228 p. 322 illus.
Verlagsort Totowa, NJ
Sprache englisch
Maße 178 x 254 mm
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Medizin / Pharmazie Naturheilkunde
Medizin / Pharmazie Pharmazie PTA / PKA
ISBN-10 1-58829-748-9 / 1588297489
ISBN-13 978-1-58829-748-8 / 9781588297488
Zustand Neuware
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