Surgical Management of Malignant Melanoma

Epidemiology of melanoma; biology of melanoma differentiation and progression; immunology of melanoma; endocrinology of melanoma; genetics and oncogens; human melanoma genetics - involvement of oncogens; photobiology; photocarcinogenesis; lesions at risk - dysplastic and congenitcal naevus; histogenetic types of primary skin melanoma; immunihistology of melanoma; pathological staging and lympth nodes; clinical presentation of primary skin melanoma; clinical staging of melanoma work up; prognosis factors; prevention and early diagnosis primary skin melanoma; management of primary melanoma; elective lymph node dissection; management of regional lymph node metastases; management of in transit metastases - isolation perfusion; pharmacokinetics and drugs in isolation perfusion; regional therapy (isolation perfusion excluded); surgical management of distant metastases - brain, lung, GI tract; adjuvant treatments; chemotherapy - new chemotherapeutical agents; controlled studies in chemotherapy for advanced disease; immunotherapy; radiation therapy; management of primary mucosal melanoma; eye melanoma; design of studies; data management and statistical analysis; technical notes.