Pediatric Thromboembolism and Stroke

Paul Monagle, MBBS, MD, MSc, FRACP, FRCPA, FCCP Professor, Chair, Head Department of Pathology University of Melbourne Director, Haematology Department of Pediatrics Royal Children's Hospital Melbourne, Australia Anthony K.C. Chan, MBBS, FRCPC Career Investigator, Heart and Stroke Foundation of Canada Medical Director, Coagulation Laboratory The Hospital for Sick Children, Toronto, Canada Professor of Pediatrics McMaster University, Hamilton, Canada M Patricia Massicotte, MD, MHSc Peter Olley Chair in Pediatric Thrombosis Professor, Pediatrics University of Alberta Edmonton, Canada Gabrielle deVeber, MD, FRCPC, MHSc Associate Professor, Department of Pediatrics University of Toronto Scientist, Population Health Sciences The Hospital for Sick Children Research Institute Director, Children's Stroke Program, Division of Neurology The Hospital for Sick Children Toronto, Canada

Preface Introduction SECTION 1: USEFUL INFORMATION Chapter 1 Developmental Hemostasis Chapter 2 Vascular Anatomy Chapter 3 Common Cardiac Surgical Procedures Chapter 4 Anticoagulant Generic and Trade Names SECTION 2: DIAGNOSIS OF THROMBOEMBOLIC DISEASE IN CHILDREN Chapter 5 Diagnosis of Noncerebral Venous Thrombosis Chapter 6 Diagnosis of Noncerebral Arterial Thrombosis Chapter 7 Diagnosis of Cerebral Sinovenous Thrombosis Chapter 8 Diagnosis of Arterial Ischemic Stroke Chapter 9 Diagnosis of Thrombophilic Conditions SECTION 3: ANTITHROMBOTIC THERAPY IN CHILDREN Chapter 10 Heparin Therapy Chapter 11 Low-Molecular-Weight Heparin Therapy Chapter 12 Subcutaneous Catheters Chapter 13 Management of Heparin-Induced Thrombocytopenia Chapter 14 Vitamin K Antagonists:Warfarin and Acenocoumarol Therapy Chapter 15 Warfarin Education Chapter 16 Elective Reversal of Warfarin Therapy Chapter 17 Systemic Thrombolytic Therapy Chapter 18 Antiplatelet Therapy Chapter 19 Surgical Interventions for Thromboembolic Disease Chapter 20 Newer Anticoagulant Drugs SECTION 4: GUIDELINES FOR ANTITHROMBOTIC THERAPY IN SPECIFIC SITUATIONS Chapter 21 Management of Blocked Central Venous Lines Chapter 22 Treatment of Deep Venous Thrombosis Chapter 23 Management of Post-thrombotic Syndrome Chapter 24 Anticoagulation Therapy for Specific Cardiac Conditions and Surgery of Childhood Chapter 25 Anticoagulation Therapy for Artificial Heart Valve Chapter 26 Treatment of Coronary Artery Disease in Children Chapter 27 Neonatal Purpura Fulminans Chapter 28 Renal Vein/Portal Vein Thrombosis Chapter 29 Management of Arterial Thrombosis SECTION 5: GUIDELINES FOR ANTITHROMBOTIC THERAPY IN STROKE Chapter 30 Acute Arterial Ischemic Stroke Chapter 31 Sinovenous Thrombosis Chapter 32 Stroke in Sickle Cell Disease SECTION 6: GUIDELINES FOR PROCEDURAL INTERVENTIONS IN CHILDREN ON ANTICOAGULANT THERAPY Chapter 33 Procedural Interventions Appendix Useful Web Sites, References and Contacts Index