Handbook of Endocannabinoid Function in the Central Nervous System

Olivier Manzoni is a Research Director at INSERM in Marseille and director of the International Associated Laboratory CannaLab (University of Indiana, Bloomington USA / Aix-Marseille University, France). His research is centered on understanding the molecular basis of synaptic plasticity in normal and pathological conditions, with a focus on the function of the endocannabinoid system and the effects of cannabis during lifetime. Vivana Trezza is an Associate Professor and Group Leader at Roma Tre University. Her research investigates the brain mechanisms underlying functional and dysfunctional socio-emotional behavior, to identify novel pharmacological targets for neuropsychiatric and neurodevelopmental disorders characterized by aberrant socio-emotional processing. A special emphasis in her research is placed on the role of the endocannabinoid system in the regulation of emotions and cognition through development.

Section I – History of the endocannabinoid system
1: An insider view of the discovery of the endocannabinoid research
2: The endocannabinoid system: present, future
3: Medical chemistry of the eCB system

Section II – Functional anatomy of the endocannabinoid system
4: The endocannabinoid signalosome
5: Endocannabinoid biosynthesis, degradation, and transport
6: Structure and distribution of endocannabinoids’ receptors
7: Endocannabinoid in glial cells
8: Endocannabinoid in non-neuronal cells of the CNS
9: Endocannabinoid – lipid interactions
10: Endocannabinoid and mitochondria
11: Sexual differences in the endocannabinoid system

Section III – The neurophysiology of the endocannabinoid system
12: Cellular effects of endocannabinoid in the CNS
13: Endocannabinoids control of excitability: from neuron to networks
14: Endocannabinoids control of synaptic transmission: from neuron to networks
15: Endocannabinoids – pain modulation
16: Endocannabinoids regulation of striatal functions
17: Endocannabinoids regulation of hippocampal functions
18: Endocannabinoids regulation of the mesolimbic system
19: Endocannabinoids regulation of cortical functions
20: Endocannabinoids regulation of spino-cerebellar functions
21: Peripheral and central endocannabinoids in the regulation of metabolism

Section IV – Endocannabinoids in development and lifetime
22: Roles of eCB in the fetal brain and early postnatal development
23: Roles of eCB in adolescence and sensitive periods
24: Roles of eCB in aging
25: Epigenetic control of eCB
26: Perinatal cannabinoid exposure

Section V – Endocannabinoids and behavioral control
27: Endocannabinoids and sensory processing
28: Endocannabinoids in motor control
29: Role of the eCB system in appetite and eating behavior
30: Endocannabinoids and the neurobiology of emotional states
31: Endocannabinoids and social behavior
32: The role of endocannabinoids in impulsivity, compulsivity, and decision-making
33: Endocannabinoids in learning and memory
34: Endocannabinoids in cognition

Section VI – Endocannabinoids in psychiatric disorders
35: Anxiety and depression
36: Endocannabinoids and schizophrenia
37: Endocannabinoid neurobiology in cannabis use disorder
38: The role of endocannabinoids in alcohol use and abuse
39: The role of endocannabinoids in psychostimulant addiction
40: The role of endocannabinoids in opioid abuse and addiction
41: Endocannabinoids in eating disorders
42: Endocannabinoids in autism spectrum disorder
43: Endocannabinoids in mental disorders
44: Endocannabinoids in OCD and Tourette’s

Section VII – Endocannabinoids in neurological disorders
45: Endocannabinoids in Parkinson's disease and neurodegenerative diseases
46: Endocannabinoids in seizures and epilepsy
47: Endocannabinoids and stroke
48: Endocannabinoids and Alzheimer’s
49: Endocannabinoids and multiple sclerosis
50: Endocannabinoids and brain cancer