Essentials of Non-Alcoholic Fatty Liver Disease

Anca Trifan, MD, PhD, FEBGH, FRCP (London) is a Professor of Gastroenterology and Internal Medicine, and Director of the Department of Internal Medicine of the "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania, Head of the Institute of Gastroenterology and Hepatology, Iasi, Romania. Her research interests include viral hepatitis, liver cirrhosis, liver transplant, acute-on chronic liver failure, non-invasive assessment of liver fibrosis, inflammatory bowel disease, biliary tract disorders, and Clostridium difficile infection. She has published numerous original papers, books and chapters of books and has been actively involved in the peer-review process of many high impact factor journals. She has been involved in the medical teaching from the beginning of her career. She received many prizes form scientific organization (e.g., Rising Stars in Gastroenterology awarded by UEG). She is past president of The Romanian Society of Gastroenterology and Hepatology,member of The Academy of Medical Sciences, member of the European Board of Gastroenterology, AGA fellow and member of The American Association for the Study of Liver Diseases.

Carol Stanciu, MD, PhD, FRCP (London) is a Professor of Gastroenterology and Internal Medicine, University of Medicine and Pharmacy "Gr. T. Popa", Iasi,  a Fellow of the Academy of Medical Sciences, and a Fellow of Romanian Academy. Dr. Carol Stanciu is one of the main founders of gastroenterology, diagnostic and therapeutic endoscopy in Romania. He graduated from the Faculty of Medicine, University of Medicine and Pharmacy "Gr.T.Popa" Iasi where he also received PhD and DSc. He is a former President of Romanian Society of Endoscopy (1996-2000), President of Romanian Society of Gastroenterology and Hepatology (2000-2008), Chairman Ethics Committee World Organization of Gastroenterology (1994-2002). He has always been involved in all areas of academic life: medical training, especiallytherapeutic endoscopy, patient care, administrative work (President of the University of Medicine and Pharmacy "Gr. T. Popa" between 1992-2004, and Dean between 2004-2008) and mentorship.  His research interests include gastrointestinal motility, viral hepatitis, liver cirrhosis, liver transplant, acute-on chronic liver failure, non-invasive assessment of liver fibrosis, inflammatory bowel disease, biliary tract disorders, and Clostridium difficile infection. He has published numerous original papers, books and book chapters and has been actively involved in the peer-review process of prestigious high impact factor journals. He received many awards from Romanian Presidency, French Presidency, WGO, Romanian Society of Gastroenterology and Hepatology and many universities.

Cristina Muzica, MD, PhD, is an Assistant Professor of Gastroenterology and Internal Medicine, University of Medicine and Pharmacy "Gr. T. Popa", Iasi. Her primary research interests are in thefield of hepatology and consist of hepatocellular carcinoma, viral hepatitis, non-alcoholic fatty liver disease and alcoholic liver diseases. During her career she published several papers including book chapters about the aforementioned themes. She is a member of the Romanian Society of Gastroenterology, United European Gastroenterology, European Association for the Study of the Liver, and Romanian Society of Neurogastroenterology.

Chapter 1: The nomenclature and definition of nonalcoholic fatty liver disease.- Chapter 2: Nonalcoholic fatty liver disease versus metabolic associated fatty liver disease.- Chapter 3: Natural history of nonalcoholic fatty liver disease.- Chapter 4: Hepatocellular carcinoma in nonalcoholic fatty liver disease.- Chapter 5: Genetics and epigenetics in nonalcoholic fatty liver disease.- Chapter 6: The place of transabdominal liver biopsy in nonalcoholic fatty liver disease.- Chapter 7: Alternative methods for liver biopsy - endoscopic ultrasound-guided and transjugular liver biopsy- endoscopic ultrasound-guided and transjugular liver biopsy.- Chapter 8: Morphopathology of nonalcoholic fatty liver disease.- Chapter 9: 2D shear wave elastography performance in the diagnosis of nonalcoholic fatty liver disease.- Chapter 10: Vibration controlled transient elastography and controlled attenuation parameter for staging nonalcoholic fatty liver disease.- Chapter 11: The value ofserologic markers/scores in the assessment of nonalcoholic fatty liver disease.- Chapter 12: Nonalcoholic fatty liver disease within other causes of chronic liver diseases.-Chapter 13: Pathophisiology and risk stratification in cardiovascular diseases and NAFLD.- Chapter 14: Type 2 diabetes mellitus and insulin resistance in nonalcoholic fatty liver disease.- Chapter 15: Nonalcoholic Fatty Liver Disease and Chronic Kidney Disease.- Chapter 16: Endocrinopathies in nonalcoholic fatty liver disease.- Chapter 17: Nonalcoholic Fatty liver disease and extraheoatic malignancies.- Chapter 18: Psychological burden of NAFLD and psychiatric disorders as extrahepatic manifestations.- Chapter 19:  Obstructive sleep apnea syndrome and nonalcoholic fatty liver disease.- Chapter 20: Nonalcoholic fatty liver disease and psoriasis.- Chapter 21: Current management and pipeline treatment approaches in NAFLD - summary of ongoing RCTs and future directions.- Chapter 22: Practical clinical cases in nonalcoholic fatty liver disease.