Clinical Hematology

Stanton L Gerson is Director of the Case Comprehensive Cancer Center & the National Center for Regenerative Medicine at Case Western Reserve University and Director of University Hospitals Seidman Cancer Center in Cleveland. Dr. Gerson studies DNA repair, stem cells and cancer therapy. He showed that over-expression of the MGMT DNA repair gene could prevent cancer and that a mutant form of MGMT protects hematopoietic stem cells from chemotherapy using lentiviral gene therapy. He has interrogated MGMT, MMR and BER DNA repair pathways as targets for cancer therapy, and proposed that methoxyamine would block base excision repair used in combination with chemotherapy. Dr. Gerson also directed the initial use of mesenchymal stem cells (MSCs) in bone marrow transplantation & in gene therapy.

I. Basic Science of Hematology * Hematopoiesis (including cytokines) * Globin/Heme * Erythrocyte structure * Red cell antigens * Granulocyte biology * Lymphocyte biology (including Ig) * Megakaryocytes and platelets * Coagulation factors * Vascular biology II. Hematologic Diseases Section 1. Diseases of Hematopoietic Cell Production * Marrow failure * Acquired aplastic anemia * Fanconi anemia and dyskeratosis congenital * Pure red cell aplasia * Myelodysplastic syndromes * Hairy cell leukemia * Large granular lymphocytic leukemia * Mineral and vitamin deficiencies * Iron deficiency * Pernicious anemia and folate deficiency * Anemia of chronic disease Section 2. Diseases of blood cell destruction * Hemolytic anemias * Inherited HA * Sickle cell disease and other hemoglobinopathies * Thalassemias * Hereditary spherocytosis * RBC enzymopathies * Acquired HA * Autoimmune HA * Paroxysmal nocturnal hemoglobinuria * Mechanical HA * Immune thrombocytopenias * ITP, PTP, neonatal TP * Drug-induced thrombocytopenia * Heparin-induced thrombocytopenia * TTP and HUS * Neutropenias * Kostmann's and other onstitutional neutropenias * Agranulocytosis, pure white cell aplasia Section 3. Malignant and proliferative hematologic diseases * Leukemias * Leukemias: diagnosis and classifications * Acute myelogenous leukemia * Secondary MDS/AML * Chronic myelogenous and myelomonocytic leukemia * Acute lymphocytic leukemia * Pediatric leukemias * Chronic lymphocytic leukemia * Myeloproliferative diseases * Polycythemia vera and essential thrombocytosis * Myelofibrosis * Hypereosinophilia * Lymphomas and lymphoid malignancies * Biology of lymphoid malignancy * Hodgkins disease * Cutaneous lymphomas * CNS lymphomas * NonHodgkins lymphomas * Infectious malignancies * HIV-1 and HTLV-1-associated lymphomas * EBV, HHV-8 * Cryoglobulinemia * Multiple myeloma * MGUS * Macroglobulinemia * Histiocytosis * Amyloidosis * Mastocytosis * Diseases of the spleen Section 4. Inherited and Acquired Metabolic Blood Diseases * Porphyrias * Hemochromatosis * Familial Mediterranean fever * ALPS Section 5. Diseases of Altered Coagulation Bleeding Disorders * Platelet diseases * Inherited and acquired platelet disorders * von Willebrands disease * Coagulation factor disorders * Hemophilias (F VIII and IX deficiencies) * Acquired inhibitors * Thrombotic disorders * Inherited deficiencies of proteins C, S; factor V * Leiden * Anti-phospholipid syndrome * Heparin-induced thrombocytopenia III. Consultative Hematology Section 1. Hematology of Growth, Development, and Aging * Hematologic complications of pregnancy * Hematology of the newborn * Pediatric hematology * Geriatric hematology Section 2. Infections of Marrow and Blood Viruses * Epstein-Barr virus * CMV * HHV-8 and other herpesviruses * Parvovirus B19 * HIV-1 and the hematology of AIDS * Hepatitis C * Dengue and hemorrhagic fever viruses * Protozoa * Malaria * Bartonellosis and others * Parasites * Hookworm Section 3. Hematologic Problems of Medical Practice Anemia * Hematologic drug reactions * Erythrocytosis * Kidney disease * Liver disease * Chronic bruising and the bleeding diathesis evaluation * Venous and arterial thrombosis * Anticoagulant therapy * Disseminated intravascular coagulation * Chemotherapy toxicities and complications Section 4. Hematologic Complications in Surgery * Evaluation of the acutely bleeding patient * Surgery in specific hematologic conditions IV. Tools for the Hematologist Section 1. Specialized practice * HLA and Transplantation of Unrelated Cells * Marrow and blood transplantation * Supportive care during transplantation * Graft-versus-host disease * Transfusion medicine * Practice of blood component transfusion * Complications of transfusion (incl hepatitis, 2o iron overload) Section 2. Laboratory methods * Blood and marrow morphology (incl histochemistry) * Flow cytometry * Cytogenetics/FISH * DNA/functional genomics * Coagulation testing