Novartis Foundation Symposium 266 – The hERG Cardiac Potassium Channel – Structure, Function and Long QT Syndrome

The Novartis Foundation is an international scientific and educational charity that promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.

Chair's introduction (Michael Sanguinetti). Gating and assembly of heteromeric hERG1a/1b channels underlying IKr in the heart (Gail A. Robertson, Eugenia M. C. Jones and Jinling Wang). Structure-function studies of outer mouth and voltage sensor domain of hERG (Gea-Ny Tseng and H. Robert Guy). General Discussion I. Voltage sensor movement in the hERG K+ channel (David R. Piper,Michael C. Sanguinetti and Martin Tristani-Firouzi). hERG channel trafficking (Eckhard Ficker, Adrienne Dennis,Yuri Kuryshev, Barbara A.Wible and Arthur M. Brown). Dynamic control of hERG/IKrr by PKA-mediated interactions with 14-3-3 (Anna Kagan and Thomas V. McDonald). General Discussion II. Does hERG coassemble with a s subunit? Evidence for roles of MinK and MiRP1 (Arun Anantharam and Geoffrey W. Abbott). hERG block, QT liability and sudden cardiac death (Arthur M. Brown). Structural determinants for high affinity block of hERG potassium channels ( John Mitcheson, Matthew Perry, Phillip Stansfeld,Mike Sanguinetti,Harry Witchel and Jules Hancox). General Discussion III. Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs (Michael C. Sanguinetti, Jun Chen, David Fernandez, Kaichiro Kamiya,John Mitcheson and Jose A. Sanchez-Chapula). In silico - modelling pharmacophores and hERG channel models (Maurizio Recanatini, Andrea Cavalli and MatteoMasetti). The long QT syndrome: a clinical counterpart of HERG mutations (Peter J. Schwartz). Cellular mechanisms of Torsade de Pointes (Steven Poelzing and David S. Rosenbaum). Expression and role of HERG channels in cancer cells (Annarosa Arcangeli). TRIad: foundation for proarrhythmia (triangulation, reverse use dependence and instability) (Luc M. Hondeghem). Drug-induced QT interval prolongation: regulatory guidance and perspectives on hERG channel studies (Rashmi R. Shah). Closing remarks (Michael Sanguinetti). Index of contributors. Subject index.