Regulatory T cells and Autoimmune Diseases (eBook)

Regulatory T cells and Autoimmune Diseases addresses recent findings concerning the role of Tregs in the pathogenesis of autoimmune diseases as well as their therapeutic aspects. In particular, this book deals with the various Treg based mechanisms which can lead to autoimmune diseases and covers the different aspects of linking Tregs with autoimmune mechanisms involved in disease development by discussing animal models and human studies. The book specifically focuses on the Treg based therapeutics and their targets to manage all known autoimmune rheumatic, central nervous system, bowel, liver, thyroid, kidney, myopathic, skin, blood & blood vessel, and eye diseases and aims to provide a must-have reference for designing therapeutic strategies to treat these autoimmune diseases. Additionally, the book covers the vaccines induced effects on functioning of Tregs and development of CAR Tregs therapy for these autoimmune diseases and concludes with current challenges and future prospects of Treg-based therapeutics. It is carefully designed to meet the requirements of both basic and advanced researchers in the area and give new dimensions and insight into the regulatory T cells' role in autoimmune disease pathogenesis and therapeutic aspects. - Brings the reader up-to-date on the mechanisms of regulatory T cells (Tregs) in pathogenesis and therapeutics of all autoimmune diseases known to date - Provides explicit color illustrations and comprehensible tables for explaining the mechanistic aspects and emerging information in the field - Includes human clinical trials and animal model studies for Tregs in diverse autoimmune diseases for the mitigation of the symptoms of autoimmune diseases - Offers scientifically applicable and relevant content for readers of various disciplines, including biomedical sciences, medical microbiology/biotechnology, immunology, and medicine

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Regulatory T cells and Autoimmune Diseases addresses recent findings concerning the role of Tregs in the pathogenesis of autoimmune diseases as well as their therapeutic aspects. In particular, this book deals with the various Treg based mechanisms which can lead to autoimmune diseases and covers the different aspects of linking Tregs with autoimmune mechanisms involved in disease development by discussing animal models and human studies. The book specifically focuses on the Treg based therapeutics and their targets to manage all known autoimmune rheumatic, central nervous system, bowel, liver, thyroid, kidney, myopathic, skin, blood & blood vessel, and eye diseases and aims to provide a must-have reference for designing therapeutic strategies to treat these autoimmune diseases. Additionally, the book covers the vaccines induced effects on functioning of Tregs and development of CAR Tregs therapy for these autoimmune diseases and concludes with current challenges and future prospects of Treg-based therapeutics. It is carefully designed to meet the requirements of both basic and advanced researchers in the area and give new dimensions and insight into the regulatory T cells' role in autoimmune disease pathogenesis and therapeutic aspects. - Brings the reader up-to-date on the mechanisms of regulatory T cells (Tregs) in pathogenesis and therapeutics of all autoimmune diseases known to date- Provides explicit color illustrations and comprehensible tables for explaining the mechanistic aspects and emerging information in the field- Includes human clinical trials and animal model studies for Tregs in diverse autoimmune diseases for the mitigation of the symptoms of autoimmune diseases- Offers scientifically applicable and relevant content for readers of various disciplines, including biomedical sciences, medical microbiology/biotechnology, immunology, and medicine