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Silica and Silica-Induced Lung Diseases

Buch | Hardcover
432 Seiten
1995
Crc Press Inc (Verlag)
978-0-8493-4709-2 (ISBN)
218,20 inkl. MwSt
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This text reviews current concepts concerning the development, progression and treatment of silica-induced lung diseases. It presents critical questions that must be resolved, and then details state-of-the-art experiments that address these problems.
This book represents a comprehensive review of current concepts concerning the development, progression, and treatment of silica-induced lung diseases. The text begins with a complete review of the historical evolution of our understanding of silicosis and a discussion of the clinical and pathological features of this disease. It presents critical questions that must be resolved and then details state-of-the-art experiments that address these problems. The book presents an extensive discussion of new technologies that have increased our understanding of the relationship of surface properties of particulates to their cytotoxicity and pathogenicity. It also presents data that explain the intracellular and intercellular mechanisms involved in the pulmonary response to silica exposure.

Background and Definitions
Pathogenic Considerations Regarding Disease Related to Silica Dust Exposure, J. Craighead
History of Silicosis, R.A. Harley and V. Vallyathan
Guidelines and Limits for Occupational Exposure to Crystalline Silica, F.J. Hearl
Clinical Features of Silicosis, D.E. Banks
Pathologic Responses to Inhaled Silica, F.H.Y. Green and V. Vallyathan
Current Concepts Concerning Physiochemical Properties of Silica
The Structure of Crystalline SiO2, G. Mandel and N. Mandel
The Structure of Silica Surfaces in Relation to Cytotoxicity, P.P. Bolsaitis and W.E. Wallace
Role of Surface Free Radicals in the Pathogenicity of Silicosis, V. Castranova, N.S. Dalal, and V. Vallyathan
Surface Properties of Silica in Mixed Dusts, W.E. Wallace, M.J. Keane, J.C. Harrison, J.W. Stephens, P.S. Brower, R.L. Grayson, and M.D. Attfield
Pathogenesis of Silicosis: Current Theories
Questions and Controversies About the Pathogenesis of Silicosis, A.B. Kane
Potential Intracellular Messengers Involved in Silica Stimulation of Alveolar Macrophages, A.J. Jabbour, R. Iyer, R.K. Scheule, and A. Holian
Calcium-Mediated Silica Cytotoxicity, Y. Rojanasakul, V. Castranova, D.E. Banks, and J.K.H. Ma
The Role of Interleukin-1 and Tumor Necrosis Factor a in the Lung's Response to Silica, K.E. Driscoll
Oxidant Release from Pulmonary Phagocytes, V. Castranova, J.M. Antonini, M.J. Reasor, L. Wu, and K. Van Dyke
Lavagable Biomarkers of Exposure to Fibrogenic Dusts, T.D. Sweeney and J.D. Brain
Early Role of Lipid Inflammatory Mediators in Silica Toxicity: Possible Methods to Detoxify Silica, K. Van Dyke, J. Gutierrez, C. Van Dyke, and L. Wu
Acute Silicosis and the Activation of Alveolar Type II Cells, G.E.R. Hook and C.J. Viviano
Fibrogenic Factors: Identity and Mode of Release, L. Couch and P.B. Bitterman
Immunological Aspects of Silicosis, R. Iyer and A. Holian
Surface Modification and Disease Prevention Modalities
Pulmonary Surfactant Adsorption and the Expression of Silica Toxicity, M.J. Keane and W.E. Wallace
Suppression of Silica-Induced Toxicity with Organosilane Surface Coating, V. Castranova, K. Van Dyke, L. Wu, N.S. Dalal, and V. Vallyathan
Suppression of the Cytotoxicity and Fibrogenicity of Silica with PVPNO, V. Castranova
Modulation of Quartz Toxicity by Aluminum, G.M. Brown and K. Donaldson
Bisbenzylisoquinoline Alkaloids: Animal Studies, V. Castranova, J.K.H. Ma, and J.Y.C. Ma
Bisbenzylisoquinoline Alkaloids: Experience from China, C. Zou, X. Lu, and S. Lu
Pharmaceutical Considerations in the Use of Tetrandrine to Treat Silicosis, J.K.H. Ma, D.-H. Chao, J.Y.C. Ma, A. Hubbs, and V. Castranova
Silica and Cancer - A Current Issue
Carcinogenesis by Crystalline Silica: Animal, Cellular, and Molecular Studies, U. Saffiotti, A.O. Williams, L.N. Daniel, M.E. Kaighn, Y. Mao, and X. Shi
Silica and Lung Cancer, J.C. McDonald
Potential Mechanisms of Silica-Induced Cancer, Z.-W. Gu and T.-m. Ong
Index

Erscheint lt. Verlag 20.12.1995
Zusatzinfo 95 equations; 34 Halftones, black and white; 38 Tables, black and white; 34 Illustrations, black and white
Verlagsort Bosa Roca
Sprache englisch
Maße 178 x 254 mm
Einbandart gebunden
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Arbeits- / Sozial- / Umweltmedizin
Medizinische Fachgebiete Innere Medizin Pneumologie
Studium 2. Studienabschnitt (Klinik) Pathologie
Studium 2. Studienabschnitt (Klinik) Pharmakologie / Toxikologie
ISBN-10 0-8493-4709-2 / 0849347092
ISBN-13 978-0-8493-4709-2 / 9780849347092
Zustand Neuware
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