Textbook of Diabetes and Pregnancy

Moshe Hod is the Director, Mor Comprehensive Women’s Health Care Center, Tel-Aviv, Israel Nir Melamed is the Head of Twins Research Centre, Director of Research, Maternal-Fetal Medicine Division, Sunnybrook Health Sciences Centre, University of Toronto, Canada Gian Carlo Di Renzo is a Professor of Obstetrics and Gynecology and Maternal Fetal Medicine, Coordinator of the Reproductive and Perinatal Medicine Center, University of Perugia; Founder and Director, PREIS International School, Firenze, Italy; and Director, Alliance of Global Women’s Medicine, GLOWM, London, UK Hema Divakar is a Gynecologist and Obstetrician at Divakar Specialty Hospital, Bangalore, India Alberto de Leiva is the Scientific Director, Fundación DIABEM, Barcelona, Spain Liona Poon is the department Chairperson AND Professor (Clinical), Co-Team Head for Maternal Medicine, Department of Obstetrics and Gynaecology, the Chinese University of Hong Kong and Prince of Wales Hospital, China Huixia Yang is the department Director and Professor for Obstetrics and Gynecology and Reproductive Medicine, and Director for Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus, Peking University First Hospital, Beijing, China Yariv Yogev is the Professor and Chairman, Lis Hospital for Women’s Health, Tel Aviv Sourasky Medical Center, and Head of Division of Obstetrics and Gynecology, Faculty of Medicine, Tel Aviv University, Israel

In Memoriam: Lois Jovanovic.

In Memoriam: Oded Langer.

Preface.

1. Prologue: Maternal medicine meets Fetal Medicine - Merging the legacies and hypotheses. 2. History of diabetic pregnancy. 3. Epidemiology of gestational diabetes mellitus. 4. The great obstetric syndromes: The roots of disease. 5. Maternal metabolism in normal and in diabetic pregnancy. 6. Nutrient delivery and fetal metabolism. 7. Pathogenesis of gestational diabetes mellitus. 8. Autoimmunity in gestational diabetes mellitus. 9. The placenta in diabetic pregnancy. 10. Gestational diabetes mellitus: The consequences of not treating. 11. Implications of diabetic pregnancy: The offspring. 12. Short-term implications: The neonate. 13. Implications of diabetic pregnancy: The mother. 14. Gestational diabetes mellitus, obesity, and pregnancy outcomes. 15. Hypertensive disorders and diabetic pregnancy. 16. Fetal congenital malformations in diabetic pregnancy. 17. Post-implantation diabetic embryopathy. 18. Congenital malformations in diabetic pregnancy. 19. Reproduction and its impact on health and disease. 20. Prediction and prevention of GDM. 21. Myoinositol and prevention of GDM. 22. The Multiomics Approach to Diabetes in Pregnancy. 23. The role of bariatric surgery in obese women planning pregnancy. 24. The Role of Glucagon-Like Peptide-1 (GLP-1) in Women with Obesity Planning Pregnancy. 25. Diagnosis of gestational diabetes. 26. Glucose intolerance in pregnancy: a window to mother and offspring future cardio-metabolic risk. 27. Ideal weight gain in Pregnancy with Diabetes. 28. Glycemic goals in diabetic pregnancy and defining "good control" - Maternal and fetal perspective. 29. Medical nutritional therapy for gestational diabetes mellitus. 30. Insulin therapy in pregnancy. 31. Use of non-insulin antihyperglycemic drugs in relation to pregnancy. 32. Continuous Subcutaneous Insulin Infusion and Continuous Glucose Monitoring in pregnancy. 33. Periconceptional assessment in Diabetic Women planning pregnancy. 34. Early pregnancy loss and perinatal mortality. 35. Fetal surveillance in diabetic pregnancies. 36. Timing and mode of delivery in diabetic pregnancy. 37. Management of the macrosomic fetus - Can fetal macrosomia be predicted and prevented? 38. Gestational Diabetes in Twin Pregnancies. 39. Fetal growth restriction in diabetic pregnancies. 40. Diabetes, obesity, hypertension, and preterm birth. 41. Diabetic retinopathy. 42. Diabetic kidney disease. 43. Diabetic ketoacidosis. 44. Thyroid in Pregnancy. 45. Gestational Diabetes in Lower and Middle-Income Countries. 46. Managing diabetic pregnancy in China. 47. Links between maternal health and noncommunicable diseases. 48. Diabetes, pregnancy, and the developmental origins of health and disease. 49. Postpartum management – mother and offspring. 50. Non-invasive glucose monitoring. 51. Closed-loop insulin delivery in type 1 diabetes pregnancy. 52. Epilogue: Maternal Fetal Medicine meets Femtech while digitalizing pregnancy management - Present and future.

Index.