Risk and Progression Factors in Carcinogenesis

This text focuses on the demonstration of important steps in carcinogenesis, ranging from chemical interaction of carcinogenes with cellular DNA in experimental tumours and cell lines to the analysis of selected human tumours.

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Cellular transformation and carcinogenesis are considered a multistep process, starting with DNA lesions and progressing through loss of cellular growth control and increased invasive and metastatic properties. This text focuses on the demonstration of important steps in carcinogenesis, ranging from chemical interaction of carcinogenes with cellular DNA in experimental tumours and cell lines to the analysis of selected human tumours. Special importance is placed on the clarification of mechanisms of DNA lesions caused by chemical carcinogens and UV irradiation.